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DHFR2 (dihydrofolate reductase 2)

Identity

Other aliasDHFRL1
DHFRP4
HGNC (Hugo) DHFR2
LocusID (NCBI) 200895
Atlas_Id 78735
Location 3q11.2  [Link to chromosome band 3q11]
Location_base_pair Starts at 94057922 and ends at 94063223 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHFR2   27309
Cards
Entrez_Gene (NCBI)DHFR2  200895  dihydrofolate reductase 2
AliasesDHFRL1; DHFRP4
GeneCards (Weizmann)DHFR2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr3:94057922-94063223 [Contig_View]  DHFR2 [Vega]
TCGA cBioPortalDHFR2
AceView (NCBI)DHFR2
Genatlas (Paris)DHFR2
WikiGenes200895
SOURCE (Princeton)DHFR2
Genetics Home Reference (NIH)DHFR2
Genomic and cartography
GoldenPath hg38 (UCSC)DHFR2  -     chr3:94057922-94063223 -  3q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHFR2  -     3q11.2   [Description]    (hg19-Feb_2009)
EnsemblDHFR2 - 3q11.2 [CytoView hg19]  DHFR2 - 3q11.2 [CytoView hg38]
Mapping of homologs : NCBIDHFR2 [Mapview hg19]  DHFR2 [Mapview hg38]
OMIM616588   
Gene and transcription
Genbank (Entrez)AK122674 AL832912 AW104373 BC045541 BC063379
RefSeq transcript (Entrez)NM_001195643 NM_176815
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DHFR2
Cluster EST : UnigeneHs.718516 [ NCBI ]
CGAP (NCI)Hs.718516
Gene ExpressionDHFR2 [ NCBI-GEO ]   DHFR2 [ EBI - ARRAY_EXPRESS ]   DHFR2 [ SEEK ]   DHFR2 [ MEM ]
Gene Expression Viewer (FireBrowse)DHFR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)200895
GTEX Portal (Tissue expression)DHFR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86XF0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86XF0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86XF0
Splice isoforms : SwissVarQ86XF0
Catalytic activity : Enzyme1.5.1.3 [ Enzyme-Expasy ]   1.5.1.31.5.1.3 [ IntEnz-EBI ]   1.5.1.3 [ BRENDA ]   1.5.1.3 [ KEGG ]   
PhosPhoSitePlusQ86XF0
Domaine pattern : Prosite (Expaxy)DHFR_2 (PS51330)   
Domains : Interpro (EBI)DHFR    DHFR-like_dom    DHFR_dom   
Domain families : Pfam (Sanger)DHFR_1 (PF00186)   
Domain families : Pfam (NCBI)pfam00186   
Conserved Domain (NCBI)DHFR2
DMDM Disease mutations200895
Blocks (Seattle)DHFR2
SuperfamilyQ86XF0
Peptide AtlasQ86XF0
HPRD11246
IPIIPI00219558   IPI00947116   
Protein Interaction databases
DIP (DOE-UCLA)Q86XF0
IntAct (EBI)Q86XF0
BioGRIDDHFR2
STRING (EMBL)DHFR2
ZODIACDHFR2
Ontologies - Pathways
QuickGOQ86XF0
Ontology : AmiGOmRNA binding  dihydrofolate reductase activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  glycine biosynthetic process  one-carbon metabolic process  nucleotide biosynthetic process  thymidine biosynthetic process  tetrahydrofolate metabolic process  tetrahydrofolate biosynthetic process  NADP binding  oxidation-reduction process  
Ontology : EGO-EBImRNA binding  dihydrofolate reductase activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  glycine biosynthetic process  one-carbon metabolic process  nucleotide biosynthetic process  thymidine biosynthetic process  tetrahydrofolate metabolic process  tetrahydrofolate biosynthetic process  NADP binding  oxidation-reduction process  
NDEx NetworkDHFR2
Atlas of Cancer Signalling NetworkDHFR2
Wikipedia pathwaysDHFR2
Orthology - Evolution
OrthoDB200895
Phylogenetic Trees/Animal Genes : TreeFamDHFR2
HOVERGENQ86XF0
HOGENOMQ86XF0
Homologs : HomoloGeneDHFR2
Homology/Alignments : Family Browser (UCSC)DHFR2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHFR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHFR2
dbVarDHFR2
ClinVarDHFR2
1000_GenomesDHFR2 
Exome Variant ServerDHFR2
ExAC (Exome Aggregation Consortium)DHFR2 (select the gene name)
Genetic variants : HAPMAP200895
Genomic Variants (DGV)DHFR2 [DGVbeta]
DECIPHERDHFR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHFR2 
Mutations
ICGC Data PortalDHFR2 
TCGA Data PortalDHFR2 
Broad Tumor PortalDHFR2
OASIS PortalDHFR2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDHFR2
BioMutasearch DHFR2
DgiDB (Drug Gene Interaction Database)DHFR2
DoCM (Curated mutations)DHFR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHFR2 (select a term)
intoGenDHFR2
Cancer3DDHFR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616588   
Orphanet
MedgenDHFR2
Genetic Testing Registry DHFR2
NextProtQ86XF0 [Medical]
TSGene200895
GENETestsDHFR2
Target ValidationDHFR2
Huge Navigator DHFR2 [HugePedia]
snp3D : Map Gene to Disease200895
BioCentury BCIQDHFR2
ClinGenDHFR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD200895
Chemical/Pharm GKB GenePA134889916
Clinical trialDHFR2
Miscellaneous
canSAR (ICR)DHFR2 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHFR2
EVEXDHFR2
GoPubMedDHFR2
iHOPDHFR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:06:13 CEST 2017

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