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DHFRL1 (dihydrofolate reductase-like 1)

Identity

Other aliasDHFRP4
HGNC (Hugo) DHFRL1
LocusID (NCBI) 200895
Atlas_Id 62462
Location 3q11.1  [Link to chromosome band 3q11]
Location_base_pair Starts at 93776766 and ends at 93782067 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DHFRL1 (3q11.1) / EMG1 (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHFRL1   27309
Cards
Entrez_Gene (NCBI)DHFRL1  200895  dihydrofolate reductase-like 1
AliasesDHFRP4
GeneCards (Weizmann)DHFRL1
Ensembl hg19 (Hinxton)ENSG00000178700 [Gene_View]  chr3:93776766-93782067 [Contig_View]  DHFRL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000178700 [Gene_View]  chr3:93776766-93782067 [Contig_View]  DHFRL1 [Vega]
ICGC DataPortalENSG00000178700
TCGA cBioPortalDHFRL1
AceView (NCBI)DHFRL1
Genatlas (Paris)DHFRL1
WikiGenes200895
SOURCE (Princeton)DHFRL1
Genetics Home Reference (NIH)DHFRL1
Genomic and cartography
GoldenPath hg19 (UCSC)DHFRL1  -     chr3:93776766-93782067 -  3q11.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DHFRL1  -     3q11.1   [Description]    (hg38-Dec_2013)
EnsemblDHFRL1 - 3q11.1 [CytoView hg19]  DHFRL1 - 3q11.1 [CytoView hg38]
Mapping of homologs : NCBIDHFRL1 [Mapview hg19]  DHFRL1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK122674 AL832912 AW104373 BC045541 BC063379
RefSeq transcript (Entrez)NM_001195643 NM_176815
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)DHFRL1
Cluster EST : UnigeneHs.718516 [ NCBI ]
CGAP (NCI)Hs.718516
Alternative Splicing GalleryENSG00000178700
Gene ExpressionDHFRL1 [ NCBI-GEO ]   DHFRL1 [ EBI - ARRAY_EXPRESS ]   DHFRL1 [ SEEK ]   DHFRL1 [ MEM ]
Gene Expression Viewer (FireBrowse)DHFRL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)200895
GTEX Portal (Tissue expression)DHFRL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86XF0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86XF0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86XF0
Splice isoforms : SwissVarQ86XF0
Catalytic activity : Enzyme1.5.1.3 [ Enzyme-Expasy ]   1.5.1.31.5.1.3 [ IntEnz-EBI ]   1.5.1.3 [ BRENDA ]   1.5.1.3 [ KEGG ]   
PhosPhoSitePlusQ86XF0
Domaine pattern : Prosite (Expaxy)DHFR_2 (PS51330)   
Domains : Interpro (EBI)DHFR    DHFR-like_dom    DHFR_dom   
Domain families : Pfam (Sanger)DHFR_1 (PF00186)   
Domain families : Pfam (NCBI)pfam00186   
Conserved Domain (NCBI)DHFRL1
DMDM Disease mutations200895
Blocks (Seattle)DHFRL1
SuperfamilyQ86XF0
Human Protein AtlasENSG00000178700
Peptide AtlasQ86XF0
HPRD11246
IPIIPI00219558   IPI00947116   
Protein Interaction databases
DIP (DOE-UCLA)Q86XF0
IntAct (EBI)Q86XF0
FunCoupENSG00000178700
BioGRIDDHFRL1
STRING (EMBL)DHFRL1
ZODIACDHFRL1
Ontologies - Pathways
QuickGOQ86XF0
Ontology : AmiGOmRNA binding  dihydrofolate reductase activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  glycine biosynthetic process  one-carbon metabolic process  nucleotide biosynthetic process  thymidine biosynthetic process  tetrahydrofolate metabolic process  tetrahydrofolate biosynthetic process  NADP binding  oxidation-reduction process  
Ontology : EGO-EBImRNA binding  dihydrofolate reductase activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  glycine biosynthetic process  one-carbon metabolic process  nucleotide biosynthetic process  thymidine biosynthetic process  tetrahydrofolate metabolic process  tetrahydrofolate biosynthetic process  NADP binding  oxidation-reduction process  
Pathways : KEGGOne carbon pool by folate    Folate biosynthesis   
NDEx NetworkDHFRL1
Atlas of Cancer Signalling NetworkDHFRL1
Wikipedia pathwaysDHFRL1
Orthology - Evolution
OrthoDB200895
GeneTree (enSembl)ENSG00000178700
Phylogenetic Trees/Animal Genes : TreeFamDHFRL1
HOVERGENQ86XF0
HOGENOMQ86XF0
Homologs : HomoloGeneDHFRL1
Homology/Alignments : Family Browser (UCSC)DHFRL1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHFRL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHFRL1
dbVarDHFRL1
ClinVarDHFRL1
1000_GenomesDHFRL1 
Exome Variant ServerDHFRL1
ExAC (Exome Aggregation Consortium)DHFRL1 (select the gene name)
Genetic variants : HAPMAP200895
Genomic Variants (DGV)DHFRL1 [DGVbeta]
DECIPHER (Syndromes)3:93776766-93782067  ENSG00000178700
CONAN: Copy Number AnalysisDHFRL1 
Mutations
ICGC Data PortalDHFRL1 
TCGA Data PortalDHFRL1 
Broad Tumor PortalDHFRL1
OASIS PortalDHFRL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHFRL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHFRL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHFRL1
DgiDB (Drug Gene Interaction Database)DHFRL1
DoCM (Curated mutations)DHFRL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHFRL1 (select a term)
intoGenDHFRL1
Cancer3DDHFRL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenDHFRL1
Genetic Testing Registry DHFRL1
NextProtQ86XF0 [Medical]
TSGene200895
GENETestsDHFRL1
Huge Navigator DHFRL1 [HugePedia]
snp3D : Map Gene to Disease200895
BioCentury BCIQDHFRL1
ClinGenDHFRL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD200895
Chemical/Pharm GKB GenePA134889916
Clinical trialDHFRL1
Miscellaneous
canSAR (ICR)DHFRL1 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHFRL1
EVEXDHFRL1
GoPubMedDHFRL1
iHOPDHFRL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:01:36 CET 2017

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