Identity
HGNC
LOCATION
16q22.2
LOCUSID
ALIAS
DHOdehase,POADS,URA1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1723
MIM: 126064
HGNC: 2867
Ensembl: ENSG00000102967
Variants:
dbSNP: 1723
ClinVar: 1723
TCGA: ENSG00000102967
COSMIC: DHODH
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 19207032 | |
| PA450192 | leflunomide | Chemical | ClinicalAnnotation | associated | PD | 19207032 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38558052 | 2024 | Pivotal role of dihydroorotate dehydrogenase as a therapeutic target in adult T-cell leukemia. | 0 |
| 38796629 | 2024 | Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma. | 0 |
| 38558052 | 2024 | Pivotal role of dihydroorotate dehydrogenase as a therapeutic target in adult T-cell leukemia. | 0 |
| 38796629 | 2024 | Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma. | 0 |
| 36825574 | 2023 | Screening for DAX1/EWS-FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma. | 3 |
| 37204046 | 2023 | Exploiting Cancer Vulnerabilities by Blocking of the DHODH and GPX4 Pathways: A Multifunctional Bodipy/PROTAC Nanoplatform for the Efficient Synergistic Ferroptosis Therapy. | 1 |
| 36825574 | 2023 | Screening for DAX1/EWS-FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma. | 3 |
| 37204046 | 2023 | Exploiting Cancer Vulnerabilities by Blocking of the DHODH and GPX4 Pathways: A Multifunctional Bodipy/PROTAC Nanoplatform for the Efficient Synergistic Ferroptosis Therapy. | 1 |
| 35094635 | 2022 | Protein production, kinetic and biophysical characterization of three human dihydroorotate dehydrogenase mutants associated with Miller syndrome. | 1 |
| 35184687 | 2022 | Protein-lipid interactions of human dihydroorotate dehydrogenase and three mutants associated with Miller syndrome. | 1 |
| 35269583 | 2022 | New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition. | 0 |
| 35943801 | 2022 | DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma. | 11 |
| 35094635 | 2022 | Protein production, kinetic and biophysical characterization of three human dihydroorotate dehydrogenase mutants associated with Miller syndrome. | 1 |
| 35184687 | 2022 | Protein-lipid interactions of human dihydroorotate dehydrogenase and three mutants associated with Miller syndrome. | 1 |
| 35269583 | 2022 | New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition. | 0 |
Citation
Dessen P
DHODH (dihydroorotate dehydrogenase (quinone))
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43228/dhodh
