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DHODH (dihydroorotate dehydrogenase (quinone))

Identity

Other namesDHOdehase
POADS
URA1
HGNC (Hugo) DHODH
LocusID (NCBI) 1723
Location 16q22.2
Location_base_pair Starts at 72042643 and ends at 72059316 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DHODH   2867
Cards
Entrez_Gene (NCBI)DHODH  1723  dihydroorotate dehydrogenase (quinone)
GeneCards (Weizmann)DHODH
Ensembl (Hinxton)ENSG00000102967 [Gene_View]  chr16:72042643-72059316 [Contig_View]  DHODH [Vega]
ICGC DataPortalENSG00000102967
AceView (NCBI)DHODH
Genatlas (Paris)DHODH
WikiGenes1723
SOURCE (Princeton)NM_001025193 NM_001361
Genomic and cartography
GoldenPath (UCSC)DHODH  -  16q22.2   chr16:72042643-72059316 +  16q22.2   [Description]    (hg19-Feb_2009)
EnsemblDHODH - 16q22.2 [CytoView]
Mapping of homologs : NCBIDHODH [Mapview]
OMIM126064   263750   
Gene and transcription
Genbank (Entrez)AI499306 AK097300 AK292293 AU130529 AU152444
RefSeq transcript (Entrez)NM_001025193 NM_001361
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_016271 NT_010498 NW_001838325 NW_004929402
Consensus coding sequences : CCDS (NCBI)DHODH
Cluster EST : UnigeneHs.654427 [ NCBI ]
CGAP (NCI)Hs.654427
Alternative Splicing : Fast-db (Paris)GSHG0011341
Alternative Splicing GalleryENSG00000102967
Gene ExpressionDHODH [ NCBI-GEO ]     DHODH [ SEEK ]   DHODH [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02127 (Uniprot)
NextProtQ02127  [Medical]
With graphics : InterProQ02127
Splice isoforms : SwissVarQ02127 (Swissvar)
Catalytic activity : Enzyme1.3.5.2 [ Enzyme-Expasy ]   1.3.5.21.3.5.2 [ IntEnz-EBI ]   1.3.5.2 [ BRENDA ]   1.3.5.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)DHODEHASE_1 (PS00911)    DHODEHASE_2 (PS00912)   
Domains : Interpro (EBI)Aldolase_TIM    Dihydroorotate_DH_1_2    Dihydroorotate_DH_2    Dihydroorotate_DH_CS   
Related proteins : CluSTrQ02127
Domain families : Pfam (Sanger)DHO_dh (PF01180)   
Domain families : Pfam (NCBI)pfam01180   
DMDM Disease mutations1723
Blocks (Seattle)Q02127
PDB (SRS)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU   
PDB (PDBSum)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU   
PDB (IMB)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU   
PDB (RSDB)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU   
Human Protein AtlasENSG00000102967
Peptide AtlasQ02127
HPRD00521
IPIIPI00024462   IPI00607764   
Protein Interaction databases
DIP (DOE-UCLA)Q02127
IntAct (EBI)Q02127
FunCoupENSG00000102967
BioGRIDDHODH
InParanoidQ02127
Interologous Interaction database Q02127
IntegromeDBDHODH
STRING (EMBL)DHODH
Ontologies - Pathways
Ontology : AmiGOdihydroorotate dehydrogenase activity  dihydroorotate oxidase activity  mitochondrial inner membrane  pyrimidine nucleobase metabolic process  'de novo' pyrimidine nucleobase biosynthetic process  female pregnancy  lactation  drug binding  FMN binding  integral component of membrane  response to caffeine  response to drug  response to starvation  neuronal cell body  positive regulation of apoptotic process  'de novo' UMP biosynthetic process  small molecule metabolic process  pyrimidine nucleoside biosynthetic process  ubiquinone binding  nucleobase-containing small molecule metabolic process  oxidation-reduction process  regulation of mitochondrial fission  
Ontology : EGO-EBIdihydroorotate dehydrogenase activity  dihydroorotate oxidase activity  mitochondrial inner membrane  pyrimidine nucleobase metabolic process  'de novo' pyrimidine nucleobase biosynthetic process  female pregnancy  lactation  drug binding  FMN binding  integral component of membrane  response to caffeine  response to drug  response to starvation  neuronal cell body  positive regulation of apoptotic process  'de novo' UMP biosynthetic process  small molecule metabolic process  pyrimidine nucleoside biosynthetic process  ubiquinone binding  nucleobase-containing small molecule metabolic process  oxidation-reduction process  regulation of mitochondrial fission  
Pathways : KEGGPyrimidine metabolism   
Protein Interaction DatabaseDHODH
Wikipedia pathwaysDHODH
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DHODH
SNP (GeneSNP Utah)DHODH
SNP : HGBaseDHODH
Genetic variants : HAPMAPDHODH
1000_GenomesDHODH 
ICGC programENSG00000102967 
CONAN: Copy Number AnalysisDHODH 
Somatic Mutations in Cancer : COSMICDHODH 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Mutations and Diseases : HGMDDHODH
OMIM126064    263750   
MedgenDHODH
GENETestsDHODH
Disease Genetic AssociationDHODH
Huge Navigator DHODH [HugePedia]  DHODH [HugeCancerGEM]
Genomic VariantsDHODH  DHODH [DGVbeta]
Exome VariantDHODH
dbVarDHODH
ClinVarDHODH
snp3D : Map Gene to Disease1723
General knowledge
Homologs : HomoloGeneDHODH
Homology/Alignments : Family Browser (UCSC)DHODH
Phylogenetic Trees/Animal Genes : TreeFamDHODH
Chemical/Protein Interactions : CTD1723
Chemical/Pharm GKB GenePA27327
Clinical trialDHODH
Cancer Resource (Charite)ENSG00000102967
Other databases
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
CoreMineDHODH
iHOPDHODH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:42:35 CEST 2014

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