Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DHODH (dihydroorotate dehydrogenase (quinone))

Identity

Other namesDHOdehase
POADS
URA1
HGNC (Hugo) DHODH
LocusID (NCBI) 1723
Location 16q22.2
Location_base_pair Starts at 72042643 and ends at 72059316 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DHODH   2867
Entrez_Gene (NCBI)DHODH  1723  dihydroorotate dehydrogenase (quinone)
Cards
GeneCards (Weizmann)DHODH
Ensembl (Hinxton)ENSG00000102967 [Gene_View]  chr16:72042643-72059316 [Contig_View]  DHODH [Vega]
AceView (NCBI)DHODH
Genatlas (Paris)DHODH
SOURCE (Stanford)NM_001025193 NM_001361
Genomic and cartography
GoldenPath (UCSC)DHODH  -  16q22.2   chr16:72042643-72059316 +  16q22.2   [Description]    (hg19-Feb_2009)
EnsemblDHODH - 16q22.2 [CytoView]
Mapping of homologs : NCBIDHODH [Mapview]
OMIM126064   263750   264750   
Gene and transcription
Genbank (Entrez)AI499306 AK097300 AK292293 AU130529 AU152444
RefSeq transcript (SRS)NM_001025193 NM_001361
RefSeq transcript (Entrez)NM_001025193 NM_001361
RefSeq genomic (SRS)AC_000148 NC_000016 NC_018927 NG_016271 NT_010498 NW_001838325 NW_004078087
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_016271 NT_010498 NW_001838325 NW_004078087
Consensus coding sequences : CCDS (NCBI)DHODH
Cluster EST : UnigeneHs.654427 [ SRS ] Hs.654427 [ NCBI ]
CGAP (NCI)Hs.654427
Alternative Splicing : Fast-db (Paris)GSHG0011341
Alternative Splicing GalleryENSG00000102967
Gene ExpressionDHODH [ NCBI-GEO ]   DHODH [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02127 (SRS) Q02127 (Uniprot)
NextProtQ02127
With graphics : InterProQ02127
Splice isoforms : SwissVarQ02127(Swissvar)
Domaine pattern : Prosite (SRS)DHODEHASE_1 (PS00911)    DHODEHASE_2 (PS00912)   
Domaine pattern : Prosite (Expaxy)DHODEHASE_1 (PS00911)    DHODEHASE_2 (PS00912)   
Domains : Interpro (SRS)Aldolase_TIM    Dihydroorotate_DH_1_2    Dihydroorotate_DH_2    Dihydroorotate_DH_CS   
Domains : Interpro (EBI)Aldolase_TIM    Dihydroorotate_DH_1_2    Dihydroorotate_DH_2    Dihydroorotate_DH_CS   
Related proteins : CluSTrQ02127
Domain families : Pfam (SRS)DHO_dh (PF01180)   
Domain families : Pfam (Sanger)DHO_dh (PF01180)   
Domain families : Pfam (NCBI)pfam01180   
DMDM1723
Blocks (Seattle)Q02127
PDB (SRS)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3ZWS    3ZWT   
PDB (PDBSum)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3ZWS    3ZWT   
PDB (IMB)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3ZWS    3ZWT   
PDB (RSDB)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3ZWS    3ZWT   
Human Protein AtlasENSG00000102967
HPRD00521
IPIIPI00024462   IPI00607764   
Protein Interaction databases
DIP (DOE-UCLA)Q02127
IntAct (EBI)Q02127
FunCoupENSG00000102967
REACTOMEDHODH
Protein Interaction Database1723
BioGRIDDHODH
InParanoidQ02127
Interologous Interaction database Q02127
IntegromeDBDHODH
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DHODH
SNP (GeneSNP Utah)DHODH
SNP : HGBaseDHODH
Genetic variants : HAPMAPDHODH
Somatic Mutations in Cancer : COSMICDHODH 
CONAN: Copy Number AnalysisDHODH 
Mutations and Diseases : HGMDDHODH
OMIM126064    263750    264750   
GENETests126064    263750    264750   
Disease Genetic AssociationDHODH
Huge Navigator DHODH [HugePedia]  DHODH [HugeCancerGEM]
Genomic VariantsDHODH  DHODH [DGVbeta]
snp3D : Map Gene to Disease1723
General knowledge
Homologs : HomoloGeneDHODH
Homology/Alignments : Family Browser (UCSC)DHODH
Phylogenetic Trees/Animal Genes : TreeFamDHODH
Catalytic activity : Enzyme1.3.5.2 [ Enzyme-Expasy ]   1.3.5.2 [ Enzyme-SRS ]   1.3.5.2 [ IntEnz-EBI ]   1.3.5.2 [ BRENDA ]   1.3.5.2 [ KEGG ]   
Chemical/Protein Interactions : CTD1723
Chemical/Pharm GKB GenePA27327
Clinical trialDHODH
Cancer Resource (Charite)ENSG00000102967
Ontology : AmiGOdihydroorotate dehydrogenase activity  dihydroorotate dehydrogenase activity  dihydroorotate oxidase activity  mitochondrial inner membrane  mitochondrial inner membrane  pyrimidine nucleobase metabolic process  'de novo' pyrimidine nucleobase biosynthetic process  integral to membrane  positive regulation of apoptotic process  'de novo' UMP biosynthetic process  small molecule metabolic process  pyrimidine nucleoside biosynthetic process  nucleobase-containing small molecule metabolic process  regulation of mitochondrial fission  
Ontology : EGO-EBIdihydroorotate dehydrogenase activity  dihydroorotate dehydrogenase activity  dihydroorotate oxidase activity  mitochondrial inner membrane  mitochondrial inner membrane  pyrimidine nucleobase metabolic process  'de novo' pyrimidine nucleobase biosynthetic process  integral to membrane  positive regulation of apoptotic process  'de novo' UMP biosynthetic process  small molecule metabolic process  pyrimidine nucleoside biosynthetic process  nucleobase-containing small molecule metabolic process  regulation of mitochondrial fission  
Pathways : KEGGPyrimidine metabolism
Other databases
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
PubGeneDHODH
iHOPDHODH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:39:24 CEST 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.