Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DHODH (dihydroorotate dehydrogenase (quinone))

Identity

Alias_namesdihydroorotate dehydrogenase
HGNC (Hugo) DHODH
LocusID (NCBI) 1723
Atlas_Id 43228
Location 16q22.2  [Link to chromosome band 16q22]
Location_base_pair Starts at 72042643 and ends at 72059316 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DHODH (16q22.2) / PKN1 (19p13.12)SIN3A (15q24.2) / DHODH (16q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHODH   2867
Cards
Entrez_Gene (NCBI)DHODH  1723  dihydroorotate dehydrogenase (quinone)
AliasesDHOdehase; POADS; URA1
GeneCards (Weizmann)DHODH
Ensembl hg19 (Hinxton)ENSG00000102967 [Gene_View]  chr16:72042643-72059316 [Contig_View]  DHODH [Vega]
Ensembl hg38 (Hinxton)ENSG00000102967 [Gene_View]  chr16:72042643-72059316 [Contig_View]  DHODH [Vega]
ICGC DataPortalENSG00000102967
TCGA cBioPortalDHODH
AceView (NCBI)DHODH
Genatlas (Paris)DHODH
WikiGenes1723
SOURCE (Princeton)DHODH
Genetics Home Reference (NIH)DHODH
Genomic and cartography
GoldenPath hg19 (UCSC)DHODH  -     chr16:72042643-72059316 +  16q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DHODH  -     16q22.2   [Description]    (hg38-Dec_2013)
EnsemblDHODH - 16q22.2 [CytoView hg19]  DHODH - 16q22.2 [CytoView hg38]
Mapping of homologs : NCBIDHODH [Mapview hg19]  DHODH [Mapview hg38]
OMIM126064   263750   
Gene and transcription
Genbank (Entrez)AI499306 AK097300 AK292293 AU130529 AU152444
RefSeq transcript (Entrez)NM_001025193 NM_001361
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_016271 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)DHODH
Cluster EST : UnigeneHs.654427 [ NCBI ]
CGAP (NCI)Hs.654427
Alternative Splicing GalleryENSG00000102967
Gene ExpressionDHODH [ NCBI-GEO ]   DHODH [ EBI - ARRAY_EXPRESS ]   DHODH [ SEEK ]   DHODH [ MEM ]
Gene Expression Viewer (FireBrowse)DHODH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1723
GTEX Portal (Tissue expression)DHODH
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02127   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02127  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02127
Splice isoforms : SwissVarQ02127
Catalytic activity : Enzyme1.3.5.2 [ Enzyme-Expasy ]   1.3.5.21.3.5.2 [ IntEnz-EBI ]   1.3.5.2 [ BRENDA ]   1.3.5.2 [ KEGG ]   
PhosPhoSitePlusQ02127
Domaine pattern : Prosite (Expaxy)DHODEHASE_1 (PS00911)    DHODEHASE_2 (PS00912)   
Domains : Interpro (EBI)Aldolase_TIM    Dihydroorotate_DH    Dihydroorotate_DH_2    Dihydroorotate_DH_CS   
Domain families : Pfam (Sanger)DHO_dh (PF01180)   
Domain families : Pfam (NCBI)pfam01180   
Conserved Domain (NCBI)DHODH
DMDM Disease mutations1723
Blocks (Seattle)DHODH
PDB (SRS)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU    4LS0    4LS1    4LS2    4OQV    4RK8    4RKA    4RLI    4RR4   
PDB (PDBSum)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU    4LS0    4LS1    4LS2    4OQV    4RK8    4RKA    4RLI    4RR4   
PDB (IMB)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU    4LS0    4LS1    4LS2    4OQV    4RK8    4RKA    4RLI    4RR4   
PDB (RSDB)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU    4LS0    4LS1    4LS2    4OQV    4RK8    4RKA    4RLI    4RR4   
Structural Biology KnowledgeBase1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU    4LS0    4LS1    4LS2    4OQV    4RK8    4RKA    4RLI    4RR4   
SCOP (Structural Classification of Proteins)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU    4LS0    4LS1    4LS2    4OQV    4RK8    4RKA    4RLI    4RR4   
CATH (Classification of proteins structures)1D3G    1D3H    2B0M    2BXV    2FPT    2FPV    2FPY    2FQI    2PRH    2PRL    2PRM    2WV8    3F1Q    3FJ6    3FJL    3G0U    3G0X    3KVJ    3KVK    3KVL    3KVM    3U2O    3W7R    3ZWS    3ZWT    4IGH    4JGD    4JS3    4JTS    4JTT    4JTU    4LS0    4LS1    4LS2    4OQV    4RK8    4RKA    4RLI    4RR4   
SuperfamilyQ02127
Human Protein AtlasENSG00000102967
Peptide AtlasQ02127
HPRD00521
IPIIPI00024462   IPI00607764   
Protein Interaction databases
DIP (DOE-UCLA)Q02127
IntAct (EBI)Q02127
FunCoupENSG00000102967
BioGRIDDHODH
STRING (EMBL)DHODH
ZODIACDHODH
Ontologies - Pathways
QuickGOQ02127
Ontology : AmiGOdihydroorotate dehydrogenase activity  dihydroorotate dehydrogenase activity  nucleoplasm  cytoplasm  mitochondrion  mitochondrial inner membrane  'de novo' pyrimidine nucleobase biosynthetic process  female pregnancy  lactation  drug binding  FMN binding  integral component of membrane  response to caffeine  response to drug  response to starvation  neuronal cell body  positive regulation of apoptotic process  'de novo' UMP biosynthetic process  pyrimidine nucleoside biosynthetic process  ubiquinone binding  oxidation-reduction process  regulation of mitochondrial fission  
Ontology : EGO-EBIdihydroorotate dehydrogenase activity  dihydroorotate dehydrogenase activity  nucleoplasm  cytoplasm  mitochondrion  mitochondrial inner membrane  'de novo' pyrimidine nucleobase biosynthetic process  female pregnancy  lactation  drug binding  FMN binding  integral component of membrane  response to caffeine  response to drug  response to starvation  neuronal cell body  positive regulation of apoptotic process  'de novo' UMP biosynthetic process  pyrimidine nucleoside biosynthetic process  ubiquinone binding  oxidation-reduction process  regulation of mitochondrial fission  
Pathways : KEGGPyrimidine metabolism   
NDEx NetworkDHODH
Atlas of Cancer Signalling NetworkDHODH
Wikipedia pathwaysDHODH
Orthology - Evolution
OrthoDB1723
GeneTree (enSembl)ENSG00000102967
Phylogenetic Trees/Animal Genes : TreeFamDHODH
HOVERGENQ02127
HOGENOMQ02127
Homologs : HomoloGeneDHODH
Homology/Alignments : Family Browser (UCSC)DHODH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHODH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHODH
dbVarDHODH
ClinVarDHODH
1000_GenomesDHODH 
Exome Variant ServerDHODH
ExAC (Exome Aggregation Consortium)DHODH (select the gene name)
Genetic variants : HAPMAP1723
Genomic Variants (DGV)DHODH [DGVbeta]
DECIPHER (Syndromes)16:72042643-72059316  ENSG00000102967
CONAN: Copy Number AnalysisDHODH 
Mutations
ICGC Data PortalDHODH 
TCGA Data PortalDHODH 
Broad Tumor PortalDHODH
OASIS PortalDHODH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHODH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHODH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DHODH
DgiDB (Drug Gene Interaction Database)DHODH
DoCM (Curated mutations)DHODH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHODH (select a term)
intoGenDHODH
Cancer3DDHODH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126064    263750   
Orphanet478   
MedgenDHODH
Genetic Testing Registry DHODH
NextProtQ02127 [Medical]
TSGene1723
GENETestsDHODH
Huge Navigator DHODH [HugePedia]
snp3D : Map Gene to Disease1723
BioCentury BCIQDHODH
ClinGenDHODH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1723
Chemical/Pharm GKB GenePA27327
Clinical trialDHODH
Miscellaneous
canSAR (ICR)DHODH (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHODH
EVEXDHODH
GoPubMedDHODH
iHOPDHODH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:35:42 CET 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.