DHPS (deoxyhypusine synthase)

2016-10-01  

Identity

HGNC
LOCATION
19p13.13
LOCUSID
ALIAS
DHS,DS,MIG13,NEDSSWI
FUSION GENES

Other Information

Locus ID:

NCBI: 1725
MIM: 600944
HGNC: 2869
Ensembl: ENSG00000095059

Variants:

dbSNP: 1725
ClinVar: 1725
TCGA: ENSG00000095059
COSMIC: DHPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095059ENST00000210060P49366
ENSG00000095059ENST00000210060A0A024R7D0
ENSG00000095059ENST00000351660P49366
ENSG00000095059ENST00000351660A0A024R7E9
ENSG00000095059ENST00000593423M0QYZ7
ENSG00000095059ENST00000594424P49366
ENSG00000095059ENST00000595100M0QX43
ENSG00000095059ENST00000595912B4E3M2
ENSG00000095059ENST00000596162M0R264
ENSG00000095059ENST00000597152M0R1T2
ENSG00000095059ENST00000598246M0R0V2
ENSG00000095059ENST00000598850M0R0J4
ENSG00000095059ENST00000600451M0QZT3
ENSG00000095059ENST00000600639M0QXT2
ENSG00000095059ENST00000600864M0R1T4
ENSG00000095059ENST00000601537Q5J8M5
ENSG00000095059ENST00000601639M0R253
ENSG00000095059ENST00000614126A0A087WZK0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Hypusine synthesis from eIF5A-lysineREACTOMER-HSA-204626

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151002162004A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex.27
127889132003Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.22
190556222008dhfr and dhps genotype and sulfadoxine-pyrimethamine treatment failure in children with falciparum malaria in the Democratic Republic of Congo.19
224914772012Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer.17
229279712012Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.16
204393162011Lrp12/Mig13a reveals changing patterns of preplate neuronal polarity during corticogenesis that are absent in reeler mutant mice.14
270415632016The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.12
147495352003Protein kinase CK2 phosphorylates and interacts with deoxyhypusine synthase in HeLa cells.2
255112112015Genetic polymorphisms associated with sulphadoxine-pyrimethamine drug resistance among Plasmodium falciparum field isolates in malaria endemic areas of Assam.2
306617712019Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.1

Citation

Dessen P

DHPS (deoxyhypusine synthase)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56398/dhps