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DHPS (deoxyhypusine synthase)

Identity

Alias_symbol (synonym)MIG13
Other aliasDHS
DS
HGNC (Hugo) DHPS
LocusID (NCBI) 1725
Atlas_Id 56398
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12675717 and ends at 12681211 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHCY (20q11.22) / DHPS (19p13.2)DHPS (19p13.2) / DHPS (19p13.2)DHPS (19p13.2) / RPS9 (19q13.42)
WDR83 (19p13.2) / DHPS (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHPS   2869
Cards
Entrez_Gene (NCBI)DHPS  1725  deoxyhypusine synthase
AliasesDHS; DS; MIG13
GeneCards (Weizmann)DHPS
Ensembl hg19 (Hinxton)ENSG00000095059 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095059 [Gene_View]  chr19:12675717-12681211 [Contig_View]  DHPS [Vega]
ICGC DataPortalENSG00000095059
TCGA cBioPortalDHPS
AceView (NCBI)DHPS
Genatlas (Paris)DHPS
WikiGenes1725
SOURCE (Princeton)DHPS
Genetics Home Reference (NIH)DHPS
Genomic and cartography
GoldenPath hg38 (UCSC)DHPS  -     chr19:12675717-12681211 -  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHPS  -     19p13.13   [Description]    (hg19-Feb_2009)
EnsemblDHPS - 19p13.13 [CytoView hg19]  DHPS - 19p13.13 [CytoView hg38]
Mapping of homologs : NCBIDHPS [Mapview hg19]  DHPS [Mapview hg38]
OMIM600944   
Gene and transcription
Genbank (Entrez)AK291553 AK300498 AK304780 AL520040 AW250887
RefSeq transcript (Entrez)NM_001206974 NM_001930 NM_013406 NM_013407
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DHPS
Cluster EST : UnigeneHs.79064 [ NCBI ]
CGAP (NCI)Hs.79064
Alternative Splicing GalleryENSG00000095059
Gene ExpressionDHPS [ NCBI-GEO ]   DHPS [ EBI - ARRAY_EXPRESS ]   DHPS [ SEEK ]   DHPS [ MEM ]
Gene Expression Viewer (FireBrowse)DHPS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1725
GTEX Portal (Tissue expression)DHPS
Human Protein AtlasENSG00000095059-DHPS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49366   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49366  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49366
Splice isoforms : SwissVarP49366
PhosPhoSitePlusP49366
Domains : Interpro (EBI)Deoxyhypusine_synthase    DHS-like_NAD/FAD-binding_dom   
Domain families : Pfam (Sanger)DS (PF01916)   
Domain families : Pfam (NCBI)pfam01916   
Conserved Domain (NCBI)DHPS
DMDM Disease mutations1725
Blocks (Seattle)DHPS
PDB (SRS)1DHS    1RLZ    1ROZ    1RQD   
PDB (PDBSum)1DHS    1RLZ    1ROZ    1RQD   
PDB (IMB)1DHS    1RLZ    1ROZ    1RQD   
PDB (RSDB)1DHS    1RLZ    1ROZ    1RQD   
Structural Biology KnowledgeBase1DHS    1RLZ    1ROZ    1RQD   
SCOP (Structural Classification of Proteins)1DHS    1RLZ    1ROZ    1RQD   
CATH (Classification of proteins structures)1DHS    1RLZ    1ROZ    1RQD   
SuperfamilyP49366
Human Protein Atlas [tissue]ENSG00000095059-DHPS [tissue]
Peptide AtlasP49366
HPRD02969
IPIIPI00026829   IPI00215771   IPI00911002   IPI00908628   IPI00552707   
Protein Interaction databases
DIP (DOE-UCLA)P49366
IntAct (EBI)P49366
FunCoupENSG00000095059
BioGRIDDHPS
STRING (EMBL)DHPS
ZODIACDHPS
Ontologies - Pathways
QuickGOP49366
Ontology : AmiGOprotein binding  cytoplasm  cytosol  translation  spermidine metabolic process  positive regulation of cell proliferation  peptidyl-lysine modification to peptidyl-hypusine  peptidyl-lysine modification to peptidyl-hypusine  deoxyhypusine synthase activity  deoxyhypusine synthase activity  positive regulation of T cell proliferation  glucose homeostasis  identical protein binding  spermidine catabolic process  protein homotetramerization  
Ontology : EGO-EBIprotein binding  cytoplasm  cytosol  translation  spermidine metabolic process  positive regulation of cell proliferation  peptidyl-lysine modification to peptidyl-hypusine  peptidyl-lysine modification to peptidyl-hypusine  deoxyhypusine synthase activity  deoxyhypusine synthase activity  positive regulation of T cell proliferation  glucose homeostasis  identical protein binding  spermidine catabolic process  protein homotetramerization  
NDEx NetworkDHPS
Atlas of Cancer Signalling NetworkDHPS
Wikipedia pathwaysDHPS
Orthology - Evolution
OrthoDB1725
GeneTree (enSembl)ENSG00000095059
Phylogenetic Trees/Animal Genes : TreeFamDHPS
HOVERGENP49366
HOGENOMP49366
Homologs : HomoloGeneDHPS
Homology/Alignments : Family Browser (UCSC)DHPS
Gene fusions - Rearrangements
Tumor Fusion PortalDHPS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHPS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHPS
dbVarDHPS
ClinVarDHPS
1000_GenomesDHPS 
Exome Variant ServerDHPS
ExAC (Exome Aggregation Consortium)ENSG00000095059
GNOMAD BrowserENSG00000095059
Genetic variants : HAPMAP1725
Genomic Variants (DGV)DHPS [DGVbeta]
DECIPHERDHPS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHPS 
Mutations
ICGC Data PortalDHPS 
TCGA Data PortalDHPS 
Broad Tumor PortalDHPS
OASIS PortalDHPS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHPS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHPS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHPS
DgiDB (Drug Gene Interaction Database)DHPS
DoCM (Curated mutations)DHPS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHPS (select a term)
intoGenDHPS
Cancer3DDHPS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600944   
Orphanet
DisGeNETDHPS
MedgenDHPS
Genetic Testing Registry DHPS
NextProtP49366 [Medical]
TSGene1725
GENETestsDHPS
Target ValidationDHPS
Huge Navigator DHPS [HugePedia]
snp3D : Map Gene to Disease1725
BioCentury BCIQDHPS
ClinGenDHPS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1725
Chemical/Pharm GKB GenePA27329
Clinical trialDHPS
Miscellaneous
canSAR (ICR)DHPS (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHPS
EVEXDHPS
GoPubMedDHPS
iHOPDHPS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:10:30 CET 2017

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