Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DHRS2 (dehydrogenase/reductase 2)

Identity

Alias_namesmember 1
Alias_symbol (synonym)HEP27
SDR25C1
Other alias
HGNC (Hugo) DHRS2
LocusID (NCBI) 10202
Atlas_Id 51136
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 23630115 and ends at 23642438 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DHRS2 (14q11.2) / PDPK1 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHRS2   18349
Cards
Entrez_Gene (NCBI)DHRS2  10202  dehydrogenase/reductase 2
AliasesHEP27; SDR25C1
GeneCards (Weizmann)DHRS2
Ensembl hg19 (Hinxton)ENSG00000100867 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100867 [Gene_View]  chr14:23630115-23642438 [Contig_View]  DHRS2 [Vega]
ICGC DataPortalENSG00000100867
TCGA cBioPortalDHRS2
AceView (NCBI)DHRS2
Genatlas (Paris)DHRS2
WikiGenes10202
SOURCE (Princeton)DHRS2
Genetics Home Reference (NIH)DHRS2
Genomic and cartography
GoldenPath hg38 (UCSC)DHRS2  -     chr14:23630115-23642438 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHRS2  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblDHRS2 - 14q11.2 [CytoView hg19]  DHRS2 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIDHRS2 [Mapview hg19]  DHRS2 [Mapview hg38]
OMIM615194   
Gene and transcription
Genbank (Entrez)AB209653 AK000345 AK092834 AK222857 AK309945
RefSeq transcript (Entrez)NM_001318835 NM_005794 NM_182908
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DHRS2
Cluster EST : UnigeneHs.272499 [ NCBI ]
CGAP (NCI)Hs.272499
Alternative Splicing GalleryENSG00000100867
Gene ExpressionDHRS2 [ NCBI-GEO ]   DHRS2 [ EBI - ARRAY_EXPRESS ]   DHRS2 [ SEEK ]   DHRS2 [ MEM ]
Gene Expression Viewer (FireBrowse)DHRS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10202
GTEX Portal (Tissue expression)DHRS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13268   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13268
Splice isoforms : SwissVarQ13268
Catalytic activity : Enzyme1.1.1.- [ Enzyme-Expasy ]   1.1.1.-1.1.1.- [ IntEnz-EBI ]   1.1.1.- [ BRENDA ]   1.1.1.- [ KEGG ]   
PhosPhoSitePlusQ13268
Domaine pattern : Prosite (Expaxy)ADH_SHORT (PS00061)   
Domains : Interpro (EBI)DHRS2    NAD(P)-bd_dom    Sc_DH/Rdtase_CS    SDR_fam   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DHRS2
DMDM Disease mutations10202
Blocks (Seattle)DHRS2
SuperfamilyQ13268
Human Protein AtlasENSG00000100867
Peptide AtlasQ13268
HPRD07483
IPIIPI00555608   IPI01025305   IPI01025431   IPI01025015   IPI00218235   IPI00944596   
Protein Interaction databases
DIP (DOE-UCLA)Q13268
IntAct (EBI)Q13268
FunCoupENSG00000100867
BioGRIDDHRS2
STRING (EMBL)DHRS2
ZODIACDHRS2
Ontologies - Pathways
QuickGOQ13268
Ontology : AmiGOcarbonyl reductase (NADPH) activity  protein binding  nucleus  nuclear envelope  cytoplasm  mitochondrion  mitochondrial matrix  C21-steroid hormone metabolic process  negative regulation of cell proliferation  response to toxic substance  cellular response to oxidative stress  myeloid dendritic cell differentiation  negative regulation of apoptotic process  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIcarbonyl reductase (NADPH) activity  protein binding  nucleus  nuclear envelope  cytoplasm  mitochondrion  mitochondrial matrix  C21-steroid hormone metabolic process  negative regulation of cell proliferation  response to toxic substance  cellular response to oxidative stress  myeloid dendritic cell differentiation  negative regulation of apoptotic process  oxidation-reduction process  extracellular exosome  
NDEx NetworkDHRS2
Atlas of Cancer Signalling NetworkDHRS2
Wikipedia pathwaysDHRS2
Orthology - Evolution
OrthoDB10202
GeneTree (enSembl)ENSG00000100867
Phylogenetic Trees/Animal Genes : TreeFamDHRS2
HOVERGENQ13268
HOGENOMQ13268
Homologs : HomoloGeneDHRS2
Homology/Alignments : Family Browser (UCSC)DHRS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHRS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHRS2
dbVarDHRS2
ClinVarDHRS2
1000_GenomesDHRS2 
Exome Variant ServerDHRS2
ExAC (Exome Aggregation Consortium)DHRS2 (select the gene name)
Genetic variants : HAPMAP10202
Genomic Variants (DGV)DHRS2 [DGVbeta]
DECIPHERDHRS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHRS2 
Mutations
ICGC Data PortalDHRS2 
TCGA Data PortalDHRS2 
Broad Tumor PortalDHRS2
OASIS PortalDHRS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHRS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHRS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHRS2
DgiDB (Drug Gene Interaction Database)DHRS2
DoCM (Curated mutations)DHRS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHRS2 (select a term)
intoGenDHRS2
Cancer3DDHRS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615194   
Orphanet
MedgenDHRS2
Genetic Testing Registry DHRS2
NextProtQ13268 [Medical]
TSGene10202
GENETestsDHRS2
Target ValidationDHRS2
Huge Navigator DHRS2 [HugePedia]
snp3D : Map Gene to Disease10202
BioCentury BCIQDHRS2
ClinGenDHRS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10202
Chemical/Pharm GKB GenePA38318
Clinical trialDHRS2
Miscellaneous
canSAR (ICR)DHRS2 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHRS2
EVEXDHRS2
GoPubMedDHRS2
iHOPDHRS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:51:37 CEST 2017

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