DHRS3 (dehydrogenase/reductase 3)

2008-09-01  

Identity

HGNC
LOCATION
1p36.21
LOCUSID
ALIAS
DD83.1,RDH17,Rsdr1,SDR1,SDR16C1,retSDR1
FUSION GENES

Other Information

Locus ID:

NCBI: 9249
MIM: 612830
HGNC: 17693
Ensembl: ENSG00000162496

Variants:

dbSNP: 9249
ClinVar: 9249
TCGA: ENSG00000162496
COSMIC: DHRS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162496ENST00000430996Q5SUY4
ENSG00000162496ENST00000464917A0A087WTY3
ENSG00000162496ENST00000616661O75911

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The retinoid cycle in cones (daylight vision)REACTOMER-HSA-2187335
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
240059082013The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.39
247333972014The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.36
296891922018Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.28
216595142011p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.25
186767422008Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis.20
205435672010The retinal dehydrogenase/reductase retSDR1/DHRS3 gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes.20
282324912017The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis.8
294470062018Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.8
283714102017New genes associated with rheumatoid arthritis identified by gene expression profiling.3

Citation

Dessen P

DHRS3 (dehydrogenase/reductase 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50385/dhrs3