Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DHRS4 (dehydrogenase/reductase 4)

Identity

Alias_namesmember 2
Alias_symbol (synonym)SCAD-SRL
SDR-SRL
humNRDR
FLJ11008
SDR25C2
Other aliasCR
NRDR
PHCR
PSCD
SDR25C1
HGNC (Hugo) DHRS4
LocusID (NCBI) 10901
Atlas_Id 47526
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 23953735 and ends at 23969281 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DHRS4 (14q11.2) / SCFD1 (14q12)DHRS4 14q11.2 / SCFD1 14q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHRS4   16985
Cards
Entrez_Gene (NCBI)DHRS4  10901  dehydrogenase/reductase 4
AliasesCR; NRDR; PHCR; PSCD; 
SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2
GeneCards (Weizmann)DHRS4
Ensembl hg19 (Hinxton)ENSG00000157326 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157326 [Gene_View]  chr14:23953735-23969281 [Contig_View]  DHRS4 [Vega]
ICGC DataPortalENSG00000157326
TCGA cBioPortalDHRS4
AceView (NCBI)DHRS4
Genatlas (Paris)DHRS4
WikiGenes10901
SOURCE (Princeton)DHRS4
Genetics Home Reference (NIH)DHRS4
Genomic and cartography
GoldenPath hg38 (UCSC)DHRS4  -     chr14:23953735-23969281 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHRS4  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblDHRS4 - 14q11.2 [CytoView hg19]  DHRS4 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIDHRS4 [Mapview hg19]  DHRS4 [Mapview hg38]
OMIM611596   
Gene and transcription
Genbank (Entrez)AA293161 AA639837 AB045131 AF044127 AF064256
RefSeq transcript (Entrez)NM_001282987 NM_001282988 NM_001282989 NM_001282990 NM_001282991 NM_021004
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DHRS4
Cluster EST : UnigeneHs.743442 [ NCBI ]
CGAP (NCI)Hs.743442
Alternative Splicing GalleryENSG00000157326
Gene ExpressionDHRS4 [ NCBI-GEO ]   DHRS4 [ EBI - ARRAY_EXPRESS ]   DHRS4 [ SEEK ]   DHRS4 [ MEM ]
Gene Expression Viewer (FireBrowse)DHRS4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10901
GTEX Portal (Tissue expression)DHRS4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BTZ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BTZ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BTZ2
Splice isoforms : SwissVarQ9BTZ2
Catalytic activity : Enzyme1.1.1.184 [ Enzyme-Expasy ]   1.1.1.1841.1.1.184 [ IntEnz-EBI ]   1.1.1.184 [ BRENDA ]   1.1.1.184 [ KEGG ]   
PhosPhoSitePlusQ9BTZ2
Domaine pattern : Prosite (Expaxy)ADH_SHORT (PS00061)   
Domains : Interpro (EBI)DHRS4-like    NAD(P)-bd_dom    Sc_DH/Rdtase_CS    SDR_fam   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DHRS4
DMDM Disease mutations10901
Blocks (Seattle)DHRS4
PDB (SRS)3O4R   
PDB (PDBSum)3O4R   
PDB (IMB)3O4R   
PDB (RSDB)3O4R   
Structural Biology KnowledgeBase3O4R   
SCOP (Structural Classification of Proteins)3O4R   
CATH (Classification of proteins structures)3O4R   
SuperfamilyQ9BTZ2
Human Protein AtlasENSG00000157326
Peptide AtlasQ9BTZ2
HPRD07484
IPIIPI00106913   IPI00152403   IPI00376623   IPI00885050   IPI00719360   IPI00885002   IPI00454647   IPI00964511   IPI00973076   IPI00973336   
Protein Interaction databases
DIP (DOE-UCLA)Q9BTZ2
IntAct (EBI)Q9BTZ2
FunCoupENSG00000157326
BioGRIDDHRS4
STRING (EMBL)DHRS4
ZODIACDHRS4
Ontologies - Pathways
QuickGOQ9BTZ2
Ontology : AmiGO3-keto sterol reductase activity  carbonyl reductase (NADPH) activity  receptor binding  nucleus  mitochondrion  peroxisome  peroxisomal membrane  endoplasmic reticulum membrane  alcohol metabolic process  steroid metabolic process  oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor  alcohol dehydrogenase [NAD(P)+] activity  cellular ketone metabolic process  retinol metabolic process  protein tetramerization  NADP-retinol dehydrogenase activity  oxidation-reduction process  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBI3-keto sterol reductase activity  carbonyl reductase (NADPH) activity  receptor binding  nucleus  mitochondrion  peroxisome  peroxisomal membrane  endoplasmic reticulum membrane  alcohol metabolic process  steroid metabolic process  oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor  alcohol dehydrogenase [NAD(P)+] activity  cellular ketone metabolic process  retinol metabolic process  protein tetramerization  NADP-retinol dehydrogenase activity  oxidation-reduction process  oxidation-reduction process  extracellular exosome  
Pathways : KEGGRetinol metabolism    Peroxisome   
NDEx NetworkDHRS4
Atlas of Cancer Signalling NetworkDHRS4
Wikipedia pathwaysDHRS4
Orthology - Evolution
OrthoDB10901
GeneTree (enSembl)ENSG00000157326
Phylogenetic Trees/Animal Genes : TreeFamDHRS4
HOVERGENQ9BTZ2
HOGENOMQ9BTZ2
Homologs : HomoloGeneDHRS4
Homology/Alignments : Family Browser (UCSC)DHRS4
Gene fusions - Rearrangements
Fusion : MitelmanDHRS4/SCFD1 [14q11.2/14q12]  
Fusion: TCGADHRS4 14q11.2 SCFD1 14q12 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHRS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHRS4
dbVarDHRS4
ClinVarDHRS4
1000_GenomesDHRS4 
Exome Variant ServerDHRS4
ExAC (Exome Aggregation Consortium)DHRS4 (select the gene name)
Genetic variants : HAPMAP10901
Genomic Variants (DGV)DHRS4 [DGVbeta]
DECIPHERDHRS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHRS4 
Mutations
ICGC Data PortalDHRS4 
TCGA Data PortalDHRS4 
Broad Tumor PortalDHRS4
OASIS PortalDHRS4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHRS4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHRS4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DHRS4
DgiDB (Drug Gene Interaction Database)DHRS4
DoCM (Curated mutations)DHRS4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHRS4 (select a term)
intoGenDHRS4
Cancer3DDHRS4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611596   
Orphanet
MedgenDHRS4
Genetic Testing Registry DHRS4
NextProtQ9BTZ2 [Medical]
TSGene10901
GENETestsDHRS4
Target ValidationDHRS4
Huge Navigator DHRS4 [HugePedia]
snp3D : Map Gene to Disease10901
BioCentury BCIQDHRS4
ClinGenDHRS4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10901
Chemical/Pharm GKB GenePA128395792
Clinical trialDHRS4
Miscellaneous
canSAR (ICR)DHRS4 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHRS4
EVEXDHRS4
GoPubMedDHRS4
iHOPDHRS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:31:07 CEST 2017

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