DHRS9 (dehydrogenase/reductase 9)

2016-08-01  

Identity

HGNC
DHRS9
LOCATION
2q31.1
LOCUSID
10170
ALIAS
3-alpha-HSD,3ALPHA-HSD,RDH-E2,RDH-TBE,RDH15,RDHL,RDHTBE,RETSDR8,SDR9C4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10170
MIM: 612131
HGNC: 16888
Ensembl: ENSG00000073737

Variants:

dbSNP: 10170
ClinVar: 10170
TCGA: ENSG00000073737
COSMIC: DHRS9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073737ENST00000357546Q9BPW9
ENSG00000073737ENST00000412271Q9BPW9
ENSG00000073737ENST00000421653Q9BPW9
ENSG00000073737ENST00000428522Q9BPW9
ENSG00000073737ENST00000432060Q9BPW9
ENSG00000073737ENST00000436483Q9BPW9
ENSG00000073737ENST00000450153C9J430
ENSG00000073737ENST00000602501Q9BPW9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
172446232007Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9.21
151900672004The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L.20
285947512017DHRS9 Is a Stable Marker of Human Regulatory Macrophages.13
166911982006A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity.7
301499922018Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma.7
262540992016Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance.6
272398452016[Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer].0

Citation

Dessen P

DHRS9 (dehydrogenase/reductase 9)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55832/dhrs9