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DHX34 (DExH-box helicase 34)

Identity

Alias (NCBI)DDX34
HRH1
HGNC (Hugo) DHX34
HGNC Alias symbKIAA0134
HGNC Previous nameDDX34
HGNC Previous nameDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34
 DEAH-box helicase 34
LocusID (NCBI) 9704
Atlas_Id 40305
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 47349315 and ends at 47382704 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC9 (19q13.32) / DHX34 (19q13.32)CIAO1 (2q11.2) / DHX34 (19q13.32)DHX34 (19q13.32) / DHX34 (19q13.32)
QDPR (4p15.32) / DHX34 (19q13.32)SLC8A2 (19q13.32) / DHX34 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  CCDC9/DHX34 (19q13)


External links

Nomenclature
HGNC (Hugo)DHX34   16719
Cards
Entrez_Gene (NCBI)DHX34    DExH-box helicase 34
AliasesDDX34; HRH1
GeneCards (Weizmann)DHX34
Ensembl hg19 (Hinxton)ENSG00000134815 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134815 [Gene_View]  ENSG00000134815 [Sequence]  chr19:47349315-47382704 [Contig_View]  DHX34 [Vega]
ICGC DataPortalENSG00000134815
TCGA cBioPortalDHX34
AceView (NCBI)DHX34
Genatlas (Paris)DHX34
SOURCE (Princeton)DHX34
Genetics Home Reference (NIH)DHX34
Genomic and cartography
GoldenPath hg38 (UCSC)DHX34  -     chr19:47349315-47382704 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHX34  -     19q13.32   [Description]    (hg19-Feb_2009)
GoldenPathDHX34 - 19q13.32 [CytoView hg19]  DHX34 - 19q13.32 [CytoView hg38]
ImmunoBaseENSG00000134815
genome Data Viewer NCBIDHX34 [Mapview hg19]  
OMIM615475   
Gene and transcription
Genbank (Entrez)AA454494 AK123046 AK297692 AK304710 AW886612
RefSeq transcript (Entrez)NM_014681 NM_194428
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DHX34
Alternative Splicing GalleryENSG00000134815
Gene ExpressionDHX34 [ NCBI-GEO ]   DHX34 [ EBI - ARRAY_EXPRESS ]   DHX34 [ SEEK ]   DHX34 [ MEM ]
Gene Expression Viewer (FireBrowse)DHX34 [ Firebrowse - Broad ]
GenevisibleExpression of DHX34 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9704
GTEX Portal (Tissue expression)DHX34
Human Protein AtlasENSG00000134815-DHX34 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14147   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14147  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14147
Splice isoforms : SwissVarQ14147
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ14147
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase   
Domain families : Pfam (Sanger)HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)   
Domain families : Pfam (NCBI)pfam04408    pfam00271    pfam07717   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  
Conserved Domain (NCBI)DHX34
Blocks (Seattle)DHX34
SuperfamilyQ14147
Human Protein Atlas [tissue]ENSG00000134815-DHX34 [tissue]
Peptide AtlasQ14147
HPRD13144
IPIIPI00382739   IPI00945772   IPI00971151   
Protein Interaction databases
DIP (DOE-UCLA)Q14147
IntAct (EBI)Q14147
BioGRIDDHX34
STRING (EMBL)DHX34
ZODIACDHX34
Ontologies - Pathways
QuickGOQ14147
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA catabolic process  RNA binding  RNA binding  RNA helicase activity  ATP binding  intracellular  membrane  negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA catabolic process  RNA binding  RNA binding  RNA helicase activity  ATP binding  intracellular  membrane  negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
NDEx NetworkDHX34
Atlas of Cancer Signalling NetworkDHX34
Wikipedia pathwaysDHX34
Orthology - Evolution
OrthoDB9704
GeneTree (enSembl)ENSG00000134815
Phylogenetic Trees/Animal Genes : TreeFamDHX34
HOGENOMQ14147
Homologs : HomoloGeneDHX34
Homology/Alignments : Family Browser (UCSC)DHX34
Gene fusions - Rearrangements
Fusion : MitelmanCCDC9/DHX34 [19q13.32/19q13.32]  
Fusion : QuiverDHX34
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHX34 [hg38]
dbVarDHX34
ClinVarDHX34
MonarchDHX34
1000_GenomesDHX34 
Exome Variant ServerDHX34
GNOMAD BrowserENSG00000134815
Varsome BrowserDHX34
Genomic Variants (DGV)DHX34 [DGVbeta]
DECIPHERDHX34 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHX34 
Mutations
ICGC Data PortalDHX34 
TCGA Data PortalDHX34 
Broad Tumor PortalDHX34
OASIS PortalDHX34 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHX34  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDHX34
Mutations and Diseases : HGMDDHX34
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHX34
DgiDB (Drug Gene Interaction Database)DHX34
DoCM (Curated mutations)DHX34 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHX34 (select a term)
intoGenDHX34
Cancer3DDHX34(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615475   
Orphanet
DisGeNETDHX34
MedgenDHX34
Genetic Testing Registry DHX34
NextProtQ14147 [Medical]
GENETestsDHX34
Target ValidationDHX34
Huge Navigator DHX34 [HugePedia]
ClinGenDHX34
Clinical trials, drugs, therapy
MyCancerGenomeDHX34
Protein Interactions : CTD
Pharm GKB GenePA27221
PharosQ14147
Clinical trialDHX34
Miscellaneous
canSAR (ICR)DHX34 (select the gene name)
HarmonizomeDHX34
DataMed IndexDHX34
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDHX34
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:12:54 CET 2021

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