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DHX34 (DExH-box helicase 34)

Identity

Alias_namesDDX34
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34
DEAH-box helicase 34
Alias_symbol (synonym)KIAA0134
Other aliasHRH1
HGNC (Hugo) DHX34
LocusID (NCBI) 9704
Atlas_Id 40305
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 47349281 and ends at 47382704 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCDC9 (19q13.32) / DHX34 (19q13.32)CIAO1 (2q11.2) / DHX34 (19q13.32)DHX34 (19q13.32) / DHX34 (19q13.32)
QDPR (4p15.32) / DHX34 (19q13.32)SLC8A2 (19q13.32) / DHX34 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHX34   16719
Cards
Entrez_Gene (NCBI)DHX34  9704  DExH-box helicase 34
AliasesDDX34; HRH1
GeneCards (Weizmann)DHX34
Ensembl hg19 (Hinxton)ENSG00000134815 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134815 [Gene_View]  chr19:47349281-47382704 [Contig_View]  DHX34 [Vega]
ICGC DataPortalENSG00000134815
TCGA cBioPortalDHX34
AceView (NCBI)DHX34
Genatlas (Paris)DHX34
WikiGenes9704
SOURCE (Princeton)DHX34
Genetics Home Reference (NIH)DHX34
Genomic and cartography
GoldenPath hg38 (UCSC)DHX34  -     chr19:47349281-47382704 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHX34  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblDHX34 - 19q13.32 [CytoView hg19]  DHX34 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIDHX34 [Mapview hg19]  DHX34 [Mapview hg38]
OMIM615475   
Gene and transcription
Genbank (Entrez)AA454494 AK123046 AK297692 AK304710 AW886612
RefSeq transcript (Entrez)NM_014681 NM_194428
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DHX34
Cluster EST : UnigeneHs.151706 [ NCBI ]
CGAP (NCI)Hs.151706
Alternative Splicing GalleryENSG00000134815
Gene ExpressionDHX34 [ NCBI-GEO ]   DHX34 [ EBI - ARRAY_EXPRESS ]   DHX34 [ SEEK ]   DHX34 [ MEM ]
Gene Expression Viewer (FireBrowse)DHX34 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9704
GTEX Portal (Tissue expression)DHX34
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14147   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14147  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14147
Splice isoforms : SwissVarQ14147
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ14147
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase   
Domain families : Pfam (Sanger)HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)   
Domain families : Pfam (NCBI)pfam04408    pfam00271    pfam07717   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  
Conserved Domain (NCBI)DHX34
DMDM Disease mutations9704
Blocks (Seattle)DHX34
SuperfamilyQ14147
Human Protein AtlasENSG00000134815
Peptide AtlasQ14147
HPRD13144
IPIIPI00382739   IPI00945772   IPI00971151   
Protein Interaction databases
DIP (DOE-UCLA)Q14147
IntAct (EBI)Q14147
FunCoupENSG00000134815
BioGRIDDHX34
STRING (EMBL)DHX34
ZODIACDHX34
Ontologies - Pathways
QuickGOQ14147
Ontology : AmiGOnuclear-transcribed mRNA catabolic process  RNA binding  ATP-dependent RNA helicase activity  ATP binding  cytoplasm  RNA processing  membrane  negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process  RNA binding  ATP-dependent RNA helicase activity  ATP binding  cytoplasm  RNA processing  membrane  negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
NDEx NetworkDHX34
Atlas of Cancer Signalling NetworkDHX34
Wikipedia pathwaysDHX34
Orthology - Evolution
OrthoDB9704
GeneTree (enSembl)ENSG00000134815
Phylogenetic Trees/Animal Genes : TreeFamDHX34
HOVERGENQ14147
HOGENOMQ14147
Homologs : HomoloGeneDHX34
Homology/Alignments : Family Browser (UCSC)DHX34
Gene fusions - Rearrangements
Fusion : MitelmanCCDC9/DHX34 [19q13.32/19q13.32]  [t(19;19)(q13;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHX34 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHX34
dbVarDHX34
ClinVarDHX34
1000_GenomesDHX34 
Exome Variant ServerDHX34
ExAC (Exome Aggregation Consortium)DHX34 (select the gene name)
Genetic variants : HAPMAP9704
Genomic Variants (DGV)DHX34 [DGVbeta]
DECIPHERDHX34 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHX34 
Mutations
ICGC Data PortalDHX34 
TCGA Data PortalDHX34 
Broad Tumor PortalDHX34
OASIS PortalDHX34 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHX34  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHX34
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHX34
DgiDB (Drug Gene Interaction Database)DHX34
DoCM (Curated mutations)DHX34 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHX34 (select a term)
intoGenDHX34
Cancer3DDHX34(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615475   
Orphanet
MedgenDHX34
Genetic Testing Registry DHX34
NextProtQ14147 [Medical]
TSGene9704
GENETestsDHX34
Target ValidationDHX34
Huge Navigator DHX34 [HugePedia]
snp3D : Map Gene to Disease9704
BioCentury BCIQDHX34
ClinGenDHX34
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9704
Chemical/Pharm GKB GenePA27221
Clinical trialDHX34
Miscellaneous
canSAR (ICR)DHX34 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHX34
EVEXDHX34
GoPubMedDHX34
iHOPDHX34
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:05:21 CEST 2017

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