Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DHX38 (DEAH-box helicase 38)

Identity

Alias_namesDDX38
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
Alias_symbol (synonym)PRP16
KIAA0224
hPrp16
PRPF16
Other alias
HGNC (Hugo) DHX38
LocusID (NCBI) 9785
Atlas_Id 47336
Location 16q22.2  [Link to chromosome band 16q22]
Location_base_pair Starts at 72127615 and ends at 72146811 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP11A (13q34) / DHX38 (16q22.2)DHX38 (16q22.2) / DHX38 (16q22.2)HAGHL (16p13.3) / DHX38 (16q22.2)
HSP90AA1 (14q32.31) / DHX38 (16q22.2)MOB2 (11p15.5) / DHX38 (16q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHX38   17211
Cards
Entrez_Gene (NCBI)DHX38  9785  DEAH-box helicase 38
AliasesDDX38; PRP16; PRPF16
GeneCards (Weizmann)DHX38
Ensembl hg19 (Hinxton)ENSG00000140829 [Gene_View]  chr16:72127615-72146811 [Contig_View]  DHX38 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140829 [Gene_View]  chr16:72127615-72146811 [Contig_View]  DHX38 [Vega]
ICGC DataPortalENSG00000140829
TCGA cBioPortalDHX38
AceView (NCBI)DHX38
Genatlas (Paris)DHX38
WikiGenes9785
SOURCE (Princeton)DHX38
Genetics Home Reference (NIH)DHX38
Genomic and cartography
GoldenPath hg19 (UCSC)DHX38  -     chr16:72127615-72146811 +  16q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DHX38  -     16q22.2   [Description]    (hg38-Dec_2013)
EnsemblDHX38 - 16q22.2 [CytoView hg19]  DHX38 - 16q22.2 [CytoView hg38]
Mapping of homologs : NCBIDHX38 [Mapview hg19]  DHX38 [Mapview hg38]
OMIM605584   
Gene and transcription
Genbank (Entrez)AA126451 AF038391 AK291634 AK293776 AK297269
RefSeq transcript (Entrez)NM_014003
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_034207 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)DHX38
Cluster EST : UnigeneHs.151218 [ NCBI ]
CGAP (NCI)Hs.151218
Alternative Splicing GalleryENSG00000140829
Gene ExpressionDHX38 [ NCBI-GEO ]   DHX38 [ EBI - ARRAY_EXPRESS ]   DHX38 [ SEEK ]   DHX38 [ MEM ]
Gene Expression Viewer (FireBrowse)DHX38 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9785
GTEX Portal (Tissue expression)DHX38
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92620   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92620  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92620
Splice isoforms : SwissVarQ92620
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ92620
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase   
Domain families : Pfam (Sanger)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)   
Domain families : Pfam (NCBI)pfam00270    pfam04408    pfam00271    pfam07717   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  
Conserved Domain (NCBI)DHX38
DMDM Disease mutations9785
Blocks (Seattle)DHX38
SuperfamilyQ92620
Human Protein AtlasENSG00000140829
Peptide AtlasQ92620
HPRD05720
IPIIPI00294211   IPI00909589   
Protein Interaction databases
DIP (DOE-UCLA)Q92620
IntAct (EBI)Q92620
FunCoupENSG00000140829
BioGRIDDHX38
STRING (EMBL)DHX38
ZODIACDHX38
Ontologies - Pathways
QuickGOQ92620
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  membrane  mRNA 3'-end processing  poly(A) RNA binding  poly(A) RNA binding  catalytic step 2 spliceosome  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  membrane  mRNA 3'-end processing  poly(A) RNA binding  poly(A) RNA binding  catalytic step 2 spliceosome  
Pathways : KEGGSpliceosome   
NDEx NetworkDHX38
Atlas of Cancer Signalling NetworkDHX38
Wikipedia pathwaysDHX38
Orthology - Evolution
OrthoDB9785
GeneTree (enSembl)ENSG00000140829
Phylogenetic Trees/Animal Genes : TreeFamDHX38
HOVERGENQ92620
HOGENOMQ92620
Homologs : HomoloGeneDHX38
Homology/Alignments : Family Browser (UCSC)DHX38
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHX38 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHX38
dbVarDHX38
ClinVarDHX38
1000_GenomesDHX38 
Exome Variant ServerDHX38
ExAC (Exome Aggregation Consortium)DHX38 (select the gene name)
Genetic variants : HAPMAP9785
Genomic Variants (DGV)DHX38 [DGVbeta]
DECIPHER (Syndromes)16:72127615-72146811  ENSG00000140829
CONAN: Copy Number AnalysisDHX38 
Mutations
ICGC Data PortalDHX38 
TCGA Data PortalDHX38 
Broad Tumor PortalDHX38
OASIS PortalDHX38 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHX38  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHX38
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHX38
DgiDB (Drug Gene Interaction Database)DHX38
DoCM (Curated mutations)DHX38 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHX38 (select a term)
intoGenDHX38
Cancer3DDHX38(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605584   
Orphanet
MedgenDHX38
Genetic Testing Registry DHX38
NextProtQ92620 [Medical]
TSGene9785
GENETestsDHX38
Huge Navigator DHX38 [HugePedia]
snp3D : Map Gene to Disease9785
BioCentury BCIQDHX38
ClinGenDHX38
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9785
Chemical/Pharm GKB GenePA27225
Clinical trialDHX38
Miscellaneous
canSAR (ICR)DHX38 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHX38
EVEXDHX38
GoPubMedDHX38
iHOPDHX38
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:58:51 CEST 2017

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