Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DHX57 (DEAH-box helicase 57)

Identity

Alias_namesDEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Alias_symbol (synonym)DDX57
Other alias
HGNC (Hugo) DHX57
LocusID (NCBI) 90957
Atlas_Id 46719
Location 2p22.1  [Link to chromosome band 2p22]
Location_base_pair Starts at 39024876 and ends at 39103021 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATL2 (2p22.2) / DHX57 (2p22.1)DHX57 (2p22.1) / FAM219A (9p13.3)DHX57 (2p22.1) / MCF2 (Xq27.1)
DHX57 (2p22.1) / SOS1 (2p22.1)MMS19 (10q24.1) / DHX57 (2p22.1)RPL37A (2q35) / DHX57 (2p22.1)
ATL2 2p22.2 / DHX57 2p22.1DHX57 2p22.1 / SOS1 2p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHX57   20086
Cards
Entrez_Gene (NCBI)DHX57  90957  DEAH-box helicase 57
AliasesDDX57
GeneCards (Weizmann)DHX57
Ensembl hg19 (Hinxton)ENSG00000163214 [Gene_View]  chr2:39024876-39103021 [Contig_View]  DHX57 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163214 [Gene_View]  chr2:39024876-39103021 [Contig_View]  DHX57 [Vega]
ICGC DataPortalENSG00000163214
TCGA cBioPortalDHX57
AceView (NCBI)DHX57
Genatlas (Paris)DHX57
WikiGenes90957
SOURCE (Princeton)DHX57
Genetics Home Reference (NIH)DHX57
Genomic and cartography
GoldenPath hg19 (UCSC)DHX57  -     chr2:39024876-39103021 -  2p22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DHX57  -     2p22.1   [Description]    (hg38-Dec_2013)
EnsemblDHX57 - 2p22.1 [CytoView hg19]  DHX57 - 2p22.1 [CytoView hg38]
Mapping of homologs : NCBIDHX57 [Mapview hg19]  DHX57 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA431324 AB209249 AF070590 AF283512 AI203420
RefSeq transcript (Entrez)NM_198963
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)DHX57
Cluster EST : UnigeneHs.468226 [ NCBI ]
CGAP (NCI)Hs.468226
Alternative Splicing GalleryENSG00000163214
Gene ExpressionDHX57 [ NCBI-GEO ]   DHX57 [ EBI - ARRAY_EXPRESS ]   DHX57 [ SEEK ]   DHX57 [ MEM ]
Gene Expression Viewer (FireBrowse)DHX57 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90957
GTEX Portal (Tissue expression)DHX57
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P158
Splice isoforms : SwissVarQ6P158
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ6P158
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    UBA (PS50030)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RWD-domain    UBA    UBA-like    Znf_CCCH   
Domain families : Pfam (Sanger)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)    RWD (PF05773)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam00270    pfam04408    pfam00271    pfam07717    pfam05773    pfam00642   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)DHX57
DMDM Disease mutations90957
Blocks (Seattle)DHX57
SuperfamilyQ6P158
Human Protein AtlasENSG00000163214
Peptide AtlasQ6P158
HPRD09919
IPIIPI00168885   IPI00749029   IPI00477424   IPI00399364   IPI00915772   IPI00917104   
Protein Interaction databases
DIP (DOE-UCLA)Q6P158
IntAct (EBI)Q6P158
FunCoupENSG00000163214
BioGRIDDHX57
STRING (EMBL)DHX57
ZODIACDHX57
Ontologies - Pathways
QuickGOQ6P158
Ontology : AmiGOATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  mitochondrion  RNA processing  poly(A) RNA binding  poly(A) RNA binding  metal ion binding  
Ontology : EGO-EBIATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  mitochondrion  RNA processing  poly(A) RNA binding  poly(A) RNA binding  metal ion binding  
NDEx NetworkDHX57
Atlas of Cancer Signalling NetworkDHX57
Wikipedia pathwaysDHX57
Orthology - Evolution
OrthoDB90957
GeneTree (enSembl)ENSG00000163214
Phylogenetic Trees/Animal Genes : TreeFamDHX57
HOVERGENQ6P158
HOGENOMQ6P158
Homologs : HomoloGeneDHX57
Homology/Alignments : Family Browser (UCSC)DHX57
Gene fusions - Rearrangements
Fusion : MitelmanATL2/DHX57 [2p22.2/2p22.1]  [t(2;2)(p22;p22)]  
Fusion : MitelmanDHX57/SOS1 [2p22.1/2p22.1]  [t(2;2)(p22;p22)]  
Fusion: TCGAATL2 2p22.2 DHX57 2p22.1 BRCA
Fusion: TCGADHX57 2p22.1 SOS1 2p22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHX57 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHX57
dbVarDHX57
ClinVarDHX57
1000_GenomesDHX57 
Exome Variant ServerDHX57
ExAC (Exome Aggregation Consortium)DHX57 (select the gene name)
Genetic variants : HAPMAP90957
Genomic Variants (DGV)DHX57 [DGVbeta]
DECIPHER (Syndromes)2:39024876-39103021  ENSG00000163214
CONAN: Copy Number AnalysisDHX57 
Mutations
ICGC Data PortalDHX57 
TCGA Data PortalDHX57 
Broad Tumor PortalDHX57
OASIS PortalDHX57 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHX57  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHX57
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHX57
DgiDB (Drug Gene Interaction Database)DHX57
DoCM (Curated mutations)DHX57 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHX57 (select a term)
intoGenDHX57
Cancer3DDHX57(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenDHX57
Genetic Testing Registry DHX57
NextProtQ6P158 [Medical]
TSGene90957
GENETestsDHX57
Huge Navigator DHX57 [HugePedia]
snp3D : Map Gene to Disease90957
BioCentury BCIQDHX57
ClinGenDHX57
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD90957
Chemical/Pharm GKB GenePA134919698
Clinical trialDHX57
Miscellaneous
canSAR (ICR)DHX57 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHX57
EVEXDHX57
GoPubMedDHX57
iHOPDHX57
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:58:52 CEST 2017

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