Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DHX57 (DExH-box helicase 57)

Identity

Alias (NCBI)DDX57
HGNC (Hugo) DHX57
HGNC Alias symbDDX57
HGNC Previous nameDEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
LocusID (NCBI) 90957
Atlas_Id 46719
Location 2p22.1  [Link to chromosome band 2p22]
Location_base_pair Starts at 38797731 and ends at 38875934 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATL2 (2p22.2)::DHX57 (2p22.1)DHX57 (2p22.1)::FAM219A (9p13.3)DHX57 (2p22.1)::MCF2 (Xq27.1)
DHX57 (2p22.1)::SOS1 (2p22.1)MMS19 (10q24.1)::DHX57 (2p22.1)RPL37A (2q35)::DHX57 (2p22.1)
ATL2 2p22.2::DHX57 2p22.1DHX57 2p22.1::SOS1 2p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DHX57   20086
Cards
Entrez_Gene (NCBI)DHX57    DExH-box helicase 57
AliasesDDX57
GeneCards (Weizmann)DHX57
Ensembl hg19 (Hinxton)ENSG00000163214 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163214 [Gene_View]  ENSG00000163214 [Sequence]  chr2:38797731-38875934 [Contig_View]  DHX57 [Vega]
ICGC DataPortalENSG00000163214
TCGA cBioPortalDHX57
AceView (NCBI)DHX57
Genatlas (Paris)DHX57
SOURCE (Princeton)DHX57
Genetics Home Reference (NIH)DHX57
Genomic and cartography
GoldenPath hg38 (UCSC)DHX57  -     chr2:38797731-38875934 -  2p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DHX57  -     2p22.1   [Description]    (hg19-Feb_2009)
GoldenPathDHX57 - 2p22.1 [CytoView hg19]  DHX57 - 2p22.1 [CytoView hg38]
ImmunoBaseENSG00000163214
Genome Data Viewer NCBIDHX57 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA431324 AB209249 AF070590 AF283512 AI203420
RefSeq transcript (Entrez)NM_001329963 NM_198963
Consensus coding sequences : CCDS (NCBI)DHX57
Gene ExpressionDHX57 [ NCBI-GEO ]   DHX57 [ EBI - ARRAY_EXPRESS ]   DHX57 [ SEEK ]   DHX57 [ MEM ]
Gene Expression Viewer (FireBrowse)DHX57 [ Firebrowse - Broad ]
GenevisibleExpression of DHX57 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90957
GTEX Portal (Tissue expression)DHX57
Human Protein AtlasENSG00000163214-DHX57 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P158
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ6P158
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    UBA (PS50030)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DHX57_UBA    DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RWD-domain    UBA    UBA-like_sf    Znf-CCCH_4    Znf_CCCH    Znf_CCCH_sf   
Domain families : Pfam (Sanger)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)    RWD (PF05773)    zf-CCCH_4 (PF18044)   
Domain families : Pfam (NCBI)pfam00270    pfam04408    pfam00271    pfam07717    pfam05773    pfam18044   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)DHX57
SuperfamilyQ6P158
AlphaFold pdb e-kbQ6P158   
Human Protein Atlas [tissue]ENSG00000163214-DHX57 [tissue]
HPRD09919
Protein Interaction databases
DIP (DOE-UCLA)Q6P158
IntAct (EBI)Q6P158
BioGRIDDHX57
STRING (EMBL)DHX57
ZODIACDHX57
Ontologies - Pathways
QuickGOQ6P158
Ontology : AmiGORNA binding  RNA binding  RNA helicase activity  protein binding  ATP binding  intracellular anatomical structure  hydrolase activity  metal ion binding  
Ontology : EGO-EBIRNA binding  RNA binding  RNA helicase activity  protein binding  ATP binding  intracellular anatomical structure  hydrolase activity  metal ion binding  
NDEx NetworkDHX57
Atlas of Cancer Signalling NetworkDHX57
Wikipedia pathwaysDHX57
Orthology - Evolution
OrthoDB90957
GeneTree (enSembl)ENSG00000163214
Phylogenetic Trees/Animal Genes : TreeFamDHX57
Homologs : HomoloGeneDHX57
Homology/Alignments : Family Browser (UCSC)DHX57
Gene fusions - Rearrangements
Fusion : MitelmanATL2::DHX57 [2p22.2/2p22.1]  
Fusion : MitelmanDHX57::SOS1 [2p22.1/2p22.1]  
Fusion : QuiverDHX57
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHX57 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHX57
dbVarDHX57
ClinVarDHX57
MonarchDHX57
1000_GenomesDHX57 
Exome Variant ServerDHX57
GNOMAD BrowserENSG00000163214
Varsome BrowserDHX57
ACMGDHX57 variants
VarityQ6P158
Genomic Variants (DGV)DHX57 [DGVbeta]
DECIPHERDHX57 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDHX57 
Mutations
ICGC Data PortalDHX57 
TCGA Data PortalDHX57 
Broad Tumor PortalDHX57
OASIS PortalDHX57 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHX57  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDHX57
Mutations and Diseases : HGMDDHX57
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDHX57
DgiDB (Drug Gene Interaction Database)DHX57
DoCM (Curated mutations)DHX57
CIViC (Clinical Interpretations of Variants in Cancer)DHX57
Cancer3DDHX57
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETDHX57
MedgenDHX57
Genetic Testing Registry DHX57
NextProtQ6P158 [Medical]
GENETestsDHX57
Target ValidationDHX57
Huge Navigator DHX57 [HugePedia]
ClinGenDHX57
Clinical trials, drugs, therapy
MyCancerGenomeDHX57
Protein Interactions : CTDDHX57
Pharm GKB GenePA134919698
PharosQ6P158
Clinical trialDHX57
Miscellaneous
canSAR (ICR)DHX57
HarmonizomeDHX57
ARCHS4DHX57
DataMed IndexDHX57
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDHX57
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jan 17 15:21:49 CET 2022

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