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DHX8 (DEAH (Asp-Glu-Ala-His) box polypeptide 8)

Identity

Other namesDDX8
HRH1
PRP22
PRPF22
HGNC (Hugo) DHX8
LocusID (NCBI) 1659
Location 17q21.31
Location_base_pair Starts at 41561334 and ends at 41601680 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DHX8   2749
Cards
Entrez_Gene (NCBI)DHX8  1659  DEAH (Asp-Glu-Ala-His) box polypeptide 8
GeneCards (Weizmann)DHX8
Ensembl (Hinxton)ENSG00000067596 [Gene_View]  chr17:41561334-41601680 [Contig_View]  DHX8 [Vega]
ICGC DataPortalENSG00000067596
AceView (NCBI)DHX8
Genatlas (Paris)DHX8
WikiGenes1659
SOURCE (Princeton)NM_004941
Genomic and cartography
GoldenPath (UCSC)DHX8  -  17q21.31   chr17:41561334-41601680 +  17q21.31   [Description]    (hg19-Feb_2009)
EnsemblDHX8 - 17q21.31 [CytoView]
Mapping of homologs : NCBIDHX8 [Mapview]
OMIM600396   
Gene and transcription
Genbank (Entrez)AK291664 AK294046 AK303319 BC020697 BC038223
RefSeq transcript (Entrez)NM_004941
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NT_010783 NW_001838437 NW_004929407
Consensus coding sequences : CCDS (NCBI)DHX8
Cluster EST : UnigeneHs.463105 [ NCBI ]
CGAP (NCI)Hs.463105
Alternative Splicing : Fast-db (Paris)GSHG0012536
Alternative Splicing GalleryENSG00000067596
Gene ExpressionDHX8 [ NCBI-GEO ]     DHX8 [ SEEK ]   DHX8 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14562 (Uniprot)
NextProtQ14562  [Medical]
With graphics : InterProQ14562
Splice isoforms : SwissVarQ14562 (Swissvar)
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    S1 (PS50126)   
Domains : Interpro (EBI)DNA/RNA_helicase_DEAD/DEAH_N    DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    NA-bd_OB-fold    P-loop_NTPase    Rbsml_prot_S1_RNA-bd_dom    RNA-binding_domain_S1   
Related proteins : CluSTrQ14562
Domain families : Pfam (Sanger)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)    S1 (PF00575)   
Domain families : Pfam (NCBI)pfam00270    pfam04408    pfam00271    pfam07717    pfam00575   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  S1 (SM00316)  
DMDM Disease mutations1659
Blocks (Seattle)Q14562
PDB (SRS)2EQS    3I4U   
PDB (PDBSum)2EQS    3I4U   
PDB (IMB)2EQS    3I4U   
PDB (RSDB)2EQS    3I4U   
Human Protein AtlasENSG00000067596
Peptide AtlasQ14562
HPRD02672
IPIIPI00031508   IPI01010550   
Protein Interaction databases
DIP (DOE-UCLA)Q14562
IntAct (EBI)Q14562
FunCoupENSG00000067596
BioGRIDDHX8
IntegromeDBDHX8
STRING (EMBL)DHX8
Ontologies - Pathways
QuickGOQ14562
Ontology : AmiGOmRNA splicing, via spliceosome  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  spliceosomal complex  nucleolus  ATP catabolic process  ATP catabolic process  RNA processing  RNA splicing  identical protein binding  poly(A) RNA binding  catalytic step 2 spliceosome  
Ontology : EGO-EBImRNA splicing, via spliceosome  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  spliceosomal complex  nucleolus  ATP catabolic process  ATP catabolic process  RNA processing  RNA splicing  identical protein binding  poly(A) RNA binding  catalytic step 2 spliceosome  
Pathways : KEGGSpliceosome   
Protein Interaction DatabaseDHX8
Wikipedia pathwaysDHX8
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DHX8
SNP (GeneSNP Utah)DHX8
SNP : HGBaseDHX8
Genetic variants : HAPMAPDHX8
1000_GenomesDHX8 
ICGC programENSG00000067596 
CONAN: Copy Number AnalysisDHX8 
Somatic Mutations in Cancer : COSMICDHX8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)17:41561334-41601680
Mutations and Diseases : HGMDDHX8
OMIM600396   
MedgenDHX8
GENETestsDHX8
Disease Genetic AssociationDHX8
Huge Navigator DHX8 [HugePedia]  DHX8 [HugeCancerGEM]
Genomic VariantsDHX8  DHX8 [DGVbeta]
Exome VariantDHX8
dbVarDHX8
ClinVarDHX8
snp3D : Map Gene to Disease1659
General knowledge
Homologs : HomoloGeneDHX8
Homology/Alignments : Family Browser (UCSC)DHX8
Phylogenetic Trees/Animal Genes : TreeFamDHX8
Chemical/Protein Interactions : CTD1659
Chemical/Pharm GKB GenePA27231
Clinical trialDHX8
Cancer Resource (Charite)ENSG00000067596
Other databases
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
CoreMineDHX8
GoPubMedDHX8
iHOPDHX8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:22:05 CET 2014

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