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DHX8 (DEAH-box helicase 8)

Identity

Alias_namesDDX8
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)
DEAH (Asp-Glu-Ala-His) box polypeptide 8
Alias_symbol (synonym)HRH1
PRP22
PRPF22
HGNC (Hugo) DHX8
LocusID (NCBI) 1659
Atlas_Id 40306
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 41561285 and ends at 41604164 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DHX8 (17q21.31) / DHX8 (17q21.31)DHX8 (17q21.31) / ETV4 (17q21.31)DHX8 (17q21.31) / GPATCH8 (17q21.31)
DHX8 (17q21.31) / SRPK2 (7q22.3)DHX8 17q21.31 / GPATCH8 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHX8   2749
Cards
Entrez_Gene (NCBI)DHX8  1659  DEAH-box helicase 8
AliasesDDX8; HRH1; PRP22; PRPF22
GeneCards (Weizmann)DHX8
Ensembl hg19 (Hinxton)ENSG00000067596 [Gene_View]  chr17:41561285-41604164 [Contig_View]  DHX8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000067596 [Gene_View]  chr17:41561285-41604164 [Contig_View]  DHX8 [Vega]
ICGC DataPortalENSG00000067596
TCGA cBioPortalDHX8
AceView (NCBI)DHX8
Genatlas (Paris)DHX8
WikiGenes1659
SOURCE (Princeton)DHX8
Genetics Home Reference (NIH)DHX8
Genomic and cartography
GoldenPath hg19 (UCSC)DHX8  -     chr17:41561285-41604164 +  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DHX8  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblDHX8 - 17q21.31 [CytoView hg19]  DHX8 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIDHX8 [Mapview hg19]  DHX8 [Mapview hg38]
OMIM600396   
Gene and transcription
Genbank (Entrez)AK291664 AK294046 AK303319 BC020697 BC038223
RefSeq transcript (Entrez)NM_001302623 NM_001322216 NM_001322217 NM_001322218 NM_001322219 NM_001322220 NM_001322221 NM_004941
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)DHX8
Cluster EST : UnigeneHs.463105 [ NCBI ]
CGAP (NCI)Hs.463105
Alternative Splicing GalleryENSG00000067596
Gene ExpressionDHX8 [ NCBI-GEO ]   DHX8 [ EBI - ARRAY_EXPRESS ]   DHX8 [ SEEK ]   DHX8 [ MEM ]
Gene Expression Viewer (FireBrowse)DHX8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1659
GTEX Portal (Tissue expression)DHX8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14562   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14562  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14562
Splice isoforms : SwissVarQ14562
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ14562
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    S1 (PS50126)   
Domains : Interpro (EBI)DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    NA-bd_OB-fold    P-loop_NTPase    S1_dom    S1_domain   
Domain families : Pfam (Sanger)HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)    S1 (PF00575)   
Domain families : Pfam (NCBI)pfam04408    pfam00271    pfam07717    pfam00575   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  S1 (SM00316)  
Conserved Domain (NCBI)DHX8
DMDM Disease mutations1659
Blocks (Seattle)DHX8
PDB (SRS)2EQS    3I4U   
PDB (PDBSum)2EQS    3I4U   
PDB (IMB)2EQS    3I4U   
PDB (RSDB)2EQS    3I4U   
Structural Biology KnowledgeBase2EQS    3I4U   
SCOP (Structural Classification of Proteins)2EQS    3I4U   
CATH (Classification of proteins structures)2EQS    3I4U   
SuperfamilyQ14562
Human Protein AtlasENSG00000067596
Peptide AtlasQ14562
HPRD02672
IPIIPI00031508   IPI01010550   
Protein Interaction databases
DIP (DOE-UCLA)Q14562
IntAct (EBI)Q14562
FunCoupENSG00000067596
BioGRIDDHX8
STRING (EMBL)DHX8
ZODIACDHX8
Ontologies - Pathways
QuickGOQ14562
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA splicing, via spliceosome  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  spliceosomal complex  cytoplasm  RNA processing  RNA splicing  identical protein binding  poly(A) RNA binding  poly(A) RNA binding  catalytic step 2 spliceosome  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA splicing, via spliceosome  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  spliceosomal complex  cytoplasm  RNA processing  RNA splicing  identical protein binding  poly(A) RNA binding  poly(A) RNA binding  catalytic step 2 spliceosome  
Pathways : KEGGSpliceosome   
NDEx NetworkDHX8
Atlas of Cancer Signalling NetworkDHX8
Wikipedia pathwaysDHX8
Orthology - Evolution
OrthoDB1659
GeneTree (enSembl)ENSG00000067596
Phylogenetic Trees/Animal Genes : TreeFamDHX8
HOVERGENQ14562
HOGENOMQ14562
Homologs : HomoloGeneDHX8
Homology/Alignments : Family Browser (UCSC)DHX8
Gene fusions - Rearrangements
Fusion : MitelmanDHX8/ETV4 [17q21.31/17q21.31]  
Fusion : MitelmanDHX8/GPATCH8 [17q21.31/17q21.31]  [t(17;17)(q21;q21)]  
Fusion: TCGADHX8 17q21.31 GPATCH8 17q21.31 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDHX8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHX8
dbVarDHX8
ClinVarDHX8
1000_GenomesDHX8 
Exome Variant ServerDHX8
ExAC (Exome Aggregation Consortium)DHX8 (select the gene name)
Genetic variants : HAPMAP1659
Genomic Variants (DGV)DHX8 [DGVbeta]
DECIPHER (Syndromes)17:41561285-41604164  ENSG00000067596
CONAN: Copy Number AnalysisDHX8 
Mutations
ICGC Data PortalDHX8 
TCGA Data PortalDHX8 
Broad Tumor PortalDHX8
OASIS PortalDHX8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDHX8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDHX8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHX8
DgiDB (Drug Gene Interaction Database)DHX8
DoCM (Curated mutations)DHX8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHX8 (select a term)
intoGenDHX8
Cancer3DDHX8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600396   
Orphanet
MedgenDHX8
Genetic Testing Registry DHX8
NextProtQ14562 [Medical]
TSGene1659
GENETestsDHX8
Huge Navigator DHX8 [HugePedia]
snp3D : Map Gene to Disease1659
BioCentury BCIQDHX8
ClinGenDHX8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1659
Chemical/Pharm GKB GenePA27231
Clinical trialDHX8
Miscellaneous
canSAR (ICR)DHX8 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHX8
EVEXDHX8
GoPubMedDHX8
iHOPDHX8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:35:45 CET 2016

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