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DHX8 (DEAH (Asp-Glu-Ala-His) box polypeptide 8)

Identity

Other namesDDX8
HRH1
PRP22
PRPF22
HGNC (Hugo) DHX8
LocusID (NCBI) 1659
Atlas_Id 40306
Location 17q21.31
Location_base_pair Starts at 41561285 and ends at 41604164 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
DHX8 17q21.31 / GPATCH8 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DHX8   2749
Cards
Entrez_Gene (NCBI)DHX8  1659  DEAH (Asp-Glu-Ala-His) box polypeptide 8
GeneCards (Weizmann)DHX8
Ensembl hg19 (Hinxton)ENSG00000067596 [Gene_View]  chr17:41561285-41604164 [Contig_View]  DHX8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000067596 [Gene_View]  chr17:41561285-41604164 [Contig_View]  DHX8 [Vega]
ICGC DataPortalENSG00000067596
TCGA cBioPortalDHX8
AceView (NCBI)DHX8
Genatlas (Paris)DHX8
WikiGenes1659
SOURCE (Princeton)DHX8
Genomic and cartography
GoldenPath hg19 (UCSC)DHX8  -     chr17:41561285-41604164 +  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DHX8  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblDHX8 - 17q21.31 [CytoView hg19]  DHX8 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIDHX8 [Mapview hg19]  DHX8 [Mapview hg38]
OMIM600396   
Gene and transcription
Genbank (Entrez)AK291664 AK294046 AK303319 BC020697 BC038223
RefSeq transcript (Entrez)NM_001302623 NM_004941
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)DHX8
Cluster EST : UnigeneHs.463105 [ NCBI ]
CGAP (NCI)Hs.463105
Alternative Splicing : Fast-db (Paris)GSHG0012536
Alternative Splicing GalleryENSG00000067596
Gene ExpressionDHX8 [ NCBI-GEO ]     DHX8 [ SEEK ]   DHX8 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)1659
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14562 (Uniprot)
NextProtQ14562  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14562
Splice isoforms : SwissVarQ14562 (Swissvar)
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.13 [ Enzyme-SRS ]   3.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ PRIAM ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   3.6.4.13 [ IUBMB ]
PhosPhoSitePlusQ14562
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    S1 (PS50126)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    NA-bd_OB-fold    P-loop_NTPase    Rbsml_prot_S1_RNA-bd_dom    S1_dom   
Domain families : Pfam (Sanger)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)    S1 (PF00575)   
Domain families : Pfam (NCBI)pfam00270    pfam04408    pfam00271    pfam07717    pfam00575   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  S1 (SM00316)  
DMDM Disease mutations1659
Blocks (Seattle)DHX8
PDB (SRS)2EQS    3I4U   
PDB (PDBSum)2EQS    3I4U   
PDB (IMB)2EQS    3I4U   
PDB (RSDB)2EQS    3I4U   
Structural Biology KnowledgeBase2EQS    3I4U   
SCOP (Structural Classification of Proteins)2EQS    3I4U   
CATH (Classification of proteins structures)2EQS    3I4U   
Human Protein AtlasENSG00000067596
Peptide AtlasQ14562
HPRD02672
IPIIPI00031508   IPI01010550   
Protein Interaction databases
DIP (DOE-UCLA)Q14562
IntAct (EBI)Q14562
FunCoupENSG00000067596
BioGRIDDHX8
IntegromeDBDHX8
STRING (EMBL)DHX8
ZODIACDHX8
Ontologies - Pathways
QuickGOQ14562
Ontology : AmiGOmRNA splicing, via spliceosome  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  spliceosomal complex  RNA processing  RNA splicing  identical protein binding  poly(A) RNA binding  poly(A) RNA binding  catalytic step 2 spliceosome  
Ontology : EGO-EBImRNA splicing, via spliceosome  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  spliceosomal complex  RNA processing  RNA splicing  identical protein binding  poly(A) RNA binding  poly(A) RNA binding  catalytic step 2 spliceosome  
Pathways : KEGGSpliceosome   
Protein Interaction DatabaseDHX8
Atlas of Cancer Signalling NetworkDHX8
Wikipedia pathwaysDHX8
Orthology - Evolution
OrthoDB1659
GeneTree (enSembl)ENSG00000067596
Phylogenetic Trees/Animal Genes : TreeFamDHX8
Homologs : HomoloGeneDHX8
Homology/Alignments : Family Browser (UCSC)DHX8
Gene fusions - Rearrangements
Fusion: TCGADHX8 17q21.31 GPATCH8 17q21.31 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerDHX8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DHX8
dbVarDHX8
ClinVarDHX8
1000_GenomesDHX8 
Exome Variant ServerDHX8
Exome Aggregation Consortium (ExAC)ENSG00000067596
SNP (GeneSNP Utah)DHX8
SNP : HGBaseDHX8
Genetic variants : HAPMAPDHX8
Genomic Variants (DGV)DHX8 [DGVbeta]
Mutations
ICGC Data PortalDHX8 
TCGA Data PortalDHX8 
Tumor PortalDHX8
TCGA Copy Number PortalDHX8
Somatic Mutations in Cancer : COSMICDHX8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DHX8
DgiDB (Drug Gene Interaction Database)DHX8
DoCM (Curated mutations)DHX8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DHX8 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:41561285-41604164
CONAN: Copy Number AnalysisDHX8 
Mutations and Diseases : HGMDDHX8
OMIM600396   
MedgenDHX8
NextProtQ14562 [Medical]
TSGene1659
GENETestsDHX8
Huge Navigator DHX8 [HugePedia]  DHX8 [HugeCancerGEM]
snp3D : Map Gene to Disease1659
BioCentury BCIQDHX8
General knowledge
Chemical/Protein Interactions : CTD1659
Chemical/Pharm GKB GenePA27231
Clinical trialDHX8
Other databases
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDHX8
GoPubMedDHX8
iHOPDHX8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 18:28:42 CET 2016

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