Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DHX8 (DEAH (Asp-Glu-Ala-His) box polypeptide 8)

Identity

Other namesDDX8
HRH1
PRP22
PRPF22
HGNC (Hugo) DHX8
LocusID (NCBI) 1659
Location 17q21.31
Location_base_pair Starts at 41561334 and ends at 41601680 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DHX8   2749
Entrez_Gene (NCBI)DHX8  1659  DEAH (Asp-Glu-Ala-His) box polypeptide 8
Cards
GeneCards (Weizmann)DHX8
Ensembl (Hinxton)ENSG00000067596 [Gene_View]  chr17:41561334-41601680 [Contig_View]  DHX8 [Vega]
AceView (NCBI)DHX8
Genatlas (Paris)DHX8
SOURCE (Stanford)NM_004941
Genomic and cartography
GoldenPath (UCSC)DHX8  -  17q21.31   chr17:41561334-41601680 +  17q21.31   [Description]    (hg19-Feb_2009)
EnsemblDHX8 - 17q21.31 [CytoView]
Mapping of homologs : NCBIDHX8 [Mapview]
OMIM600396   
Gene and transcription
Genbank (Entrez)AK291664 AK294046 AK303319 BC020697 BC038223
RefSeq transcript (SRS)NM_004941
RefSeq transcript (Entrez)NM_004941
RefSeq genomic (SRS)AC_000149 NC_000017 NC_018928 NT_010783 NW_001838437 NW_004078092
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NT_010783 NW_001838437 NW_004078092
Consensus coding sequences : CCDS (NCBI)DHX8
Cluster EST : UnigeneHs.463105 [ SRS ] Hs.463105 [ NCBI ]
CGAP (NCI)Hs.463105
Alternative Splicing : Fast-db (Paris)GSHG0012536
Alternative Splicing GalleryENSG00000067596
Gene ExpressionDHX8 [ NCBI-GEO ]   DHX8 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14562 (SRS) Q14562 (Uniprot)
NextProtQ14562
With graphics : InterProQ14562
Splice isoforms : SwissVarQ14562(Swissvar)
Domaine pattern : Prosite (SRS)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    S1 (PS50126)   
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    S1 (PS50126)   
Domains : Interpro (SRS)DNA/RNA_helicase_DEAD/DEAH_N    DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    NA-bd_OB-fold    NA-bd_OB-fold-like    Rbsml_prot_S1_RNA-bd_dom    RNA-binding_domain_S1   
Domains : Interpro (EBI)DNA/RNA_helicase_DEAD/DEAH_N    DNA/RNA_helicase_DEAH_CS    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    NA-bd_OB-fold    NA-bd_OB-fold-like    Rbsml_prot_S1_RNA-bd_dom    RNA-binding_domain_S1   
Related proteins : CluSTrQ14562
Domain families : Pfam (SRS)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)    S1 (PF00575)   
Domain families : Pfam (Sanger)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)    S1 (PF00575)   
Domain families : Pfam (NCBI)pfam00270    pfam04408    pfam00271    pfam07717    pfam00575   
Domain families : Smart (EMBL)DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  S1 (SM00316)  
DMDM1659
Blocks (Seattle)Q14562
PDB (SRS)2EQS    3I4U   
PDB (PDBSum)2EQS    3I4U   
PDB (IMB)2EQS    3I4U   
PDB (RSDB)2EQS    3I4U   
Human Protein AtlasENSG00000067596
HPRD02672
IPIIPI00031508   IPI01010550   
Protein Interaction databases
DIP (DOE-UCLA)Q14562
IntAct (EBI)Q14562
FunCoupENSG00000067596
REACTOMEDHX8
Protein Interaction Database1659
BioGRIDDHX8
InParanoidQ14562
Interologous Interaction database Q14562
IntegromeDBDHX8
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DHX8
SNP (GeneSNP Utah)DHX8
SNP : HGBaseDHX8
Genetic variants : HAPMAPDHX8
Somatic Mutations in Cancer : COSMICDHX8 
CONAN: Copy Number AnalysisDHX8 
Mutations and Diseases : HGMDDHX8
OMIM600396   
GENETests600396   
Disease Genetic AssociationDHX8
Huge Navigator DHX8 [HugePedia]  DHX8 [HugeCancerGEM]
Genomic VariantsDHX8  DHX8 [DGVbeta]
snp3D : Map Gene to Disease1659
General knowledge
Homologs : HomoloGeneDHX8
Homology/Alignments : Family Browser (UCSC)DHX8
Phylogenetic Trees/Animal Genes : TreeFamDHX8
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.13 [ Enzyme-SRS ]   3.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
Chemical/Protein Interactions : CTD1659
Chemical/Pharm GKB GenePA27231
Clinical trialDHX8
Cancer Resource (Charite)ENSG00000067596
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  spliceosomal complex  nucleolus  RNA processing  RNA splicing  catalytic step 2 spliceosome  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  spliceosomal complex  nucleolus  RNA processing  RNA splicing  catalytic step 2 spliceosome  
Other databases
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
PubGeneDHX8
iHOPDHX8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:50:24 CEST 2013
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