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DICER1 (dicer 1, ribonuclease type III)

Identity

Other namesDCR1
Dicer
HERNA
MNG1
RMSE2
HGNC (Hugo) DICER1
LocusID (NCBI) 23405
Location 14q32.13
Location_base_pair Starts at 95552565 and ends at 95599840 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DICER1   17098
Cards
Entrez_Gene (NCBI)DICER1  23405  dicer 1, ribonuclease type III
GeneCards (Weizmann)DICER1
Ensembl (Hinxton)ENSG00000100697 [Gene_View]  chr14:95552565-95599840 [Contig_View]  DICER1 [Vega]
ICGC DataPortalENSG00000100697
AceView (NCBI)DICER1
Genatlas (Paris)DICER1
WikiGenes23405
SOURCE (Princeton)NM_001195573 NM_001271282 NM_001291628 NM_030621 NM_177438
Genomic and cartography
GoldenPath (UCSC)DICER1  -  14q32.13   chr14:95552565-95599840 -  14q32.13   [Description]    (hg19-Feb_2009)
EnsemblDICER1 - 14q32.13 [CytoView]
Mapping of homologs : NCBIDICER1 [Mapview]
OMIM138800   180295   601200   606241   
Gene and transcription
Genbank (Entrez)AB023145 AB028449 AF007142 AJ132261 AK001041
RefSeq transcript (Entrez)NM_001195573 NM_001271282 NM_001291628 NM_030621 NM_177438
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_016311 NT_026437 NW_001838113 NW_004929393
Consensus coding sequences : CCDS (NCBI)DICER1
Cluster EST : UnigeneHs.738957 [ NCBI ]
CGAP (NCI)Hs.738957
Alternative Splicing : Fast-db (Paris)GSHG0009596
Alternative Splicing GalleryENSG00000100697
Gene ExpressionDICER1 [ NCBI-GEO ]     DICER1 [ SEEK ]   DICER1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPY3 (Uniprot)
NextProtQ9UPY3  [Medical]
With graphics : InterProQ9UPY3
Splice isoforms : SwissVarQ9UPY3 (Swissvar)
Catalytic activity : Enzyme3.1.26.3 [ Enzyme-Expasy ]   3.1.26.33.1.26.3 [ IntEnz-EBI ]   3.1.26.3 [ BRENDA ]   3.1.26.3 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)DICER_DSRBF (PS51327)    DS_RBD (PS50137)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    PAZ (PS50821)    RNASE_3_1 (PS00517)    RNASE_3_2 (PS50142)   
Domains : Interpro (EBI)Dicer_dimerisation_dom    DNA/RNA_helicase_DEAD/DEAH_N    dsRNA-bd_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    PAZ_dom    RNase_III_dom   
Related proteins : CluSTrQ9UPY3
Domain families : Pfam (Sanger)DEAD (PF00270)    Dicer_dimer (PF03368)    Helicase_C (PF00271)    PAZ (PF02170)    Ribonuclease_3 (PF00636)   
Domain families : Pfam (NCBI)pfam00270    pfam03368    pfam00271    pfam02170    pfam00636   
Domain families : Smart (EMBL)DEXDc (SM00487)  DSRM (SM00358)  HELICc (SM00490)  PAZ (SM00949)  RIBOc (SM00535)  
DMDM Disease mutations23405
Blocks (Seattle)Q9UPY3
PDB (SRS)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA   
PDB (PDBSum)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA   
PDB (IMB)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA   
PDB (RSDB)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA   
Human Protein AtlasENSG00000100697
Peptide AtlasQ9UPY3
HPRD05875
IPIIPI00219036   IPI01025259   IPI01025417   IPI00977554   IPI00977945   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPY3
IntAct (EBI)Q9UPY3
FunCoupENSG00000100697
BioGRIDDICER1
InParanoidQ9UPY3
Interologous Interaction database Q9UPY3
IntegromeDBDICER1
STRING (EMBL)DICER1
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  angiogenesis  double-stranded RNA binding  helicase activity  ribonuclease III activity  protein binding  ATP binding  endoplasmic reticulum-Golgi intermediate compartment  cytosol  post-embryonic development  zygote asymmetric cell division  gene expression  negative regulation of Schwann cell proliferation  positive regulation of Schwann cell differentiation  RISC complex  stem cell maintenance  spinal cord motor neuron differentiation  nerve development  olfactory bulb interneuron differentiation  cerebral cortex development  lung development  production of siRNA involved in RNA interference  targeting of mRNA for destruction involved in RNA interference  axon  dendrite  growth cone  pre-miRNA processing  hair follicle morphogenesis  positive regulation of myelination  peripheral nervous system myelin formation  embryonic hindlimb morphogenesis  production of miRNAs involved in gene silencing by miRNA  miRNA binding  multicellular organism growth  regulation of viral genome replication  regulation of neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  spleen development  regulation of oligodendrocyte differentiation  branching morphogenesis of an epithelial tube  neuron projection morphogenesis  spindle assembly  defense response to virus  regulation of cell cycle  cardiac muscle cell development  inner ear receptor cell development  intestinal epithelial cell development  regulation of enamel mineralization  hair follicle cell proliferation  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  RNA phosphodiester bond hydrolysis, endonucleolytic  positive regulation of miRNA metabolic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  angiogenesis  double-stranded RNA binding  helicase activity  ribonuclease III activity  protein binding  ATP binding  endoplasmic reticulum-Golgi intermediate compartment  cytosol  post-embryonic development  zygote asymmetric cell division  gene expression  negative regulation of Schwann cell proliferation  positive regulation of Schwann cell differentiation  RISC complex  stem cell maintenance  spinal cord motor neuron differentiation  nerve development  olfactory bulb interneuron differentiation  cerebral cortex development  lung development  production of siRNA involved in RNA interference  targeting of mRNA for destruction involved in RNA interference  axon  dendrite  growth cone  pre-miRNA processing  hair follicle morphogenesis  positive regulation of myelination  peripheral nervous system myelin formation  embryonic hindlimb morphogenesis  production of miRNAs involved in gene silencing by miRNA  miRNA binding  multicellular organism growth  regulation of viral genome replication  regulation of neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  spleen development  regulation of oligodendrocyte differentiation  branching morphogenesis of an epithelial tube  neuron projection morphogenesis  spindle assembly  defense response to virus  regulation of cell cycle  cardiac muscle cell development  inner ear receptor cell development  intestinal epithelial cell development  regulation of enamel mineralization  hair follicle cell proliferation  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  RNA phosphodiester bond hydrolysis, endonucleolytic  positive regulation of miRNA metabolic process  
Pathways : BIOCARTADicer Pathway [Genes]   
Pathways : KEGGMicroRNAs in cancer   
Protein Interaction DatabaseDICER1
Wikipedia pathwaysDICER1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DICER1
SNP (GeneSNP Utah)DICER1
SNP : HGBaseDICER1
Genetic variants : HAPMAPDICER1
1000_GenomesDICER1 
ICGC programENSG00000100697 
Cancer Gene: CensusDICER1 
CONAN: Copy Number AnalysisDICER1 
Somatic Mutations in Cancer : COSMICDICER1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
Mutations and Diseases : HGMDDICER1
OMIM138800    180295    601200    606241   
MedgenDICER1
GENETestsDICER1
Disease Genetic AssociationDICER1
Huge Navigator DICER1 [HugePedia]  DICER1 [HugeCancerGEM]
Genomic VariantsDICER1  DICER1 [DGVbeta]
Exome VariantDICER1
dbVarDICER1
ClinVarDICER1
snp3D : Map Gene to Disease23405
General knowledge
Homologs : HomoloGeneDICER1
Homology/Alignments : Family Browser (UCSC)DICER1
Phylogenetic Trees/Animal Genes : TreeFamDICER1
Chemical/Protein Interactions : CTD23405
Chemical/Pharm GKB GenePA38437
Clinical trialDICER1
Cancer Resource (Charite)ENSG00000100697
Other databases
Probes
Litterature
PubMed217 Pubmed reference(s) in Entrez
CoreMineDICER1
iHOPDICER1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:42:43 CEST 2014

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