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DICER1 (dicer 1, ribonuclease III)

Identity

Other namesDCR1
Dicer
Dicer1e
HERNA
K12H4.8-LIKE
MNG1
RMSE2
HGNC (Hugo) DICER1
LocusID (NCBI) 23405
Atlas_Id 45773
Location 14q32.13
Location_base_pair Starts at 95552565 and ends at 95599840 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DICER1 (14q32.13) / CCDC14 (3q21.1)DICER1 (14q32.13) / NEK7 (1q31.3)RAB7A (3q21.3) / DICER1 (14q32.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DICER1   17098
Cards
Entrez_Gene (NCBI)DICER1  23405  dicer 1, ribonuclease III
AliasesDCR1; Dicer; Dicer1e; HERNA; 
K12H4.8-LIKE; MNG1; RMSE2
GeneCards (Weizmann)DICER1
Ensembl hg19 (Hinxton)ENSG00000100697 [Gene_View]  chr14:95552565-95599840 [Contig_View]  DICER1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100697 [Gene_View]  chr14:95552565-95599840 [Contig_View]  DICER1 [Vega]
ICGC DataPortalENSG00000100697
TCGA cBioPortalDICER1
AceView (NCBI)DICER1
Genatlas (Paris)DICER1
WikiGenes23405
SOURCE (Princeton)DICER1
Genomic and cartography
GoldenPath hg19 (UCSC)DICER1  -     chr14:95552565-95599840 -  14q32.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DICER1  -     14q32.13   [Description]    (hg38-Dec_2013)
EnsemblDICER1 - 14q32.13 [CytoView hg19]  DICER1 - 14q32.13 [CytoView hg38]
Mapping of homologs : NCBIDICER1 [Mapview hg19]  DICER1 [Mapview hg38]
OMIM138800   180295   601200   606241   
Gene and transcription
Genbank (Entrez)AB023145 AB028449 AF007142 AJ132261 AK001041
RefSeq transcript (Entrez)NM_001195573 NM_001271282 NM_001291628 NM_030621 NM_177438
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_016311 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)DICER1
Cluster EST : UnigeneHs.738957 [ NCBI ]
CGAP (NCI)Hs.738957
Alternative Splicing GalleryENSG00000100697
Gene ExpressionDICER1 [ NCBI-GEO ]   DICER1 [ EBI - ARRAY_EXPRESS ]   DICER1 [ SEEK ]   DICER1 [ MEM ]
Gene Expression Viewer (FireBrowse)DICER1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23405
GTEX Portal (Tissue expression)DICER1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPY3 (Uniprot)
NextProtQ9UPY3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPY3
Splice isoforms : SwissVarQ9UPY3 (Swissvar)
Catalytic activity : Enzyme3.1.26.3 [ Enzyme-Expasy ]   3.1.26.33.1.26.3 [ IntEnz-EBI ]   3.1.26.3 [ BRENDA ]   3.1.26.3 [ KEGG ]   
PhosPhoSitePlusQ9UPY3
Domaine pattern : Prosite (Expaxy)DICER_DSRBF (PS51327)    DS_RBD (PS50137)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    PAZ (PS50821)    RNASE_3_1 (PS00517)    RNASE_3_2 (PS50142)   
Domains : Interpro (EBI)Dicer_dimerisation_dom    dsRBD_dom    Helicase/UvrB_N    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    PAZ_dom    RNase_III_dom   
Domain families : Pfam (Sanger)Dicer_dimer (PF03368)    Helicase_C (PF00271)    PAZ (PF02170)    ResIII (PF04851)    Ribonuclease_3 (PF00636)   
Domain families : Pfam (NCBI)pfam03368    pfam00271    pfam02170    pfam04851    pfam00636   
Domain families : Smart (EMBL)DEXDc (SM00487)  DSRM (SM00358)  HELICc (SM00490)  PAZ (SM00949)  RIBOc (SM00535)  
DMDM Disease mutations23405
Blocks (Seattle)DICER1
PDB (SRS)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA    4WYQ   
PDB (PDBSum)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA    4WYQ   
PDB (IMB)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA    4WYQ   
PDB (RSDB)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA    4WYQ   
Structural Biology KnowledgeBase2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA    4WYQ   
SCOP (Structural Classification of Proteins)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA    4WYQ   
CATH (Classification of proteins structures)2EB1    4NGB    4NGC    4NGD    4NGF    4NGG    4NH3    4NH5    4NH6    4NHA    4WYQ   
SuperfamilyQ9UPY3
Human Protein AtlasENSG00000100697
Peptide AtlasQ9UPY3
HPRD05875
IPIIPI00219036   IPI01025259   IPI01025417   IPI00977554   IPI00977945   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPY3
IntAct (EBI)Q9UPY3
FunCoupENSG00000100697
BioGRIDDICER1
STRING (EMBL)DICER1
ZODIACDICER1
Ontologies - Pathways
QuickGOQ9UPY3
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  double-stranded RNA binding  double-stranded RNA binding  helicase activity  endoribonuclease activity  endoribonuclease activity  endoribonuclease activity  ribonuclease III activity  ribonuclease III activity  deoxyribonuclease I activity  protein binding  ATP binding  nucleus  cytoplasm  endoplasmic reticulum-Golgi intermediate compartment  cytosol  apoptotic DNA fragmentation  negative regulation of Schwann cell proliferation  positive regulation of Schwann cell differentiation  RISC complex  protein domain specific binding  nerve development  production of siRNA involved in RNA interference  targeting of mRNA for destruction involved in RNA interference  axon  dendrite  growth cone  gene silencing by RNA  pre-miRNA processing  positive regulation of myelination  peripheral nervous system myelin formation  ARC complex  conversion of ds siRNA to ss siRNA involved in RNA interference  siRNA loading onto RISC involved in RNA interference  production of miRNAs involved in gene silencing by miRNA  production of miRNAs involved in gene silencing by miRNA  siRNA binding  miRNA loading onto RISC involved in gene silencing by miRNA  conversion of ds siRNA to ss siRNA  metal ion binding  neuron projection morphogenesis  RISC-loading complex  pre-miRNA binding  pre-miRNA binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  double-stranded RNA binding  double-stranded RNA binding  helicase activity  endoribonuclease activity  endoribonuclease activity  endoribonuclease activity  ribonuclease III activity  ribonuclease III activity  deoxyribonuclease I activity  protein binding  ATP binding  nucleus  cytoplasm  endoplasmic reticulum-Golgi intermediate compartment  cytosol  apoptotic DNA fragmentation  negative regulation of Schwann cell proliferation  positive regulation of Schwann cell differentiation  RISC complex  protein domain specific binding  nerve development  production of siRNA involved in RNA interference  targeting of mRNA for destruction involved in RNA interference  axon  dendrite  growth cone  gene silencing by RNA  pre-miRNA processing  positive regulation of myelination  peripheral nervous system myelin formation  ARC complex  conversion of ds siRNA to ss siRNA involved in RNA interference  siRNA loading onto RISC involved in RNA interference  production of miRNAs involved in gene silencing by miRNA  production of miRNAs involved in gene silencing by miRNA  siRNA binding  miRNA loading onto RISC involved in gene silencing by miRNA  conversion of ds siRNA to ss siRNA  metal ion binding  neuron projection morphogenesis  RISC-loading complex  pre-miRNA binding  pre-miRNA binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Pathways : BIOCARTADicer Pathway [Genes]   
Pathways : KEGGMicroRNAs in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkDICER1
Wikipedia pathwaysDICER1
Orthology - Evolution
OrthoDB23405
GeneTree (enSembl)ENSG00000100697
Phylogenetic Trees/Animal Genes : TreeFamDICER1
Homologs : HomoloGeneDICER1
Homology/Alignments : Family Browser (UCSC)DICER1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerDICER1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DICER1
dbVarDICER1
ClinVarDICER1
1000_GenomesDICER1 
Exome Variant ServerDICER1
ExAC (Exome Aggregation Consortium)DICER1 (select the gene name)
Genetic variants : HAPMAP23405
Genomic Variants (DGV)DICER1 [DGVbeta]
Mutations
ICGC Data PortalDICER1 
TCGA Data PortalDICER1 
Broad Tumor PortalDICER1
OASIS PortalDICER1 [ Somatic mutations - Copy number]
Cancer Gene: CensusDICER1 
Somatic Mutations in Cancer : COSMICDICER1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch DICER1
DgiDB (Drug Gene Interaction Database)DICER1
DoCM (Curated mutations)DICER1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DICER1 (select a term)
intoGenDICER1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:95552565-95599840  ENSG00000100697
CONAN: Copy Number AnalysisDICER1 
Mutations and Diseases : HGMDDICER1
OMIM138800    180295    601200    606241   
MedgenDICER1
Genetic Testing Registry DICER1
NextProtQ9UPY3 [Medical]
TSGene23405
GENETestsDICER1
Huge Navigator DICER1 [HugePedia]
snp3D : Map Gene to Disease23405
BioCentury BCIQDICER1
ClinGenDICER1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23405
Chemical/Pharm GKB GenePA38437
Clinical trialDICER1
Miscellaneous
canSAR (ICR)DICER1 (select the gene name)
Probes
Litterature
PubMed302 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDICER1
EVEXDICER1
GoPubMedDICER1
iHOPDICER1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:00:21 CEST 2016

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