Assignment of type II iodothyronine deiodinase gene (DIO2) to human chromosome band 14q24.2-->q24.3 by in situ hybridization. |
Araki O, Murakami M, Morimura T, Kamiya Y, Hosoi Y, Kato Y, Mori M. |
Cytogenet Cell Genet. 1999;84(1-2):73-4. |
PMID 10343107 |
|
Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors. |
Arnaldi LA, Borra RC, Maciel RM, Cerutti JM. |
Thyroid. 2005 Mar;15(3):210-21. |
PMID 15785240 |
|
Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. |
Bartha T, Kim SW, Salvatore D, Gereben B, Tu HM, Harney JW, Rudas P, Larsen PR. |
Endocrinology. 2000 Jan;141(1):229-37. |
PMID 10614643 |
|
Adaptive activation of thyroid hormone and energy expenditure. |
Bianco AC, Maia AL, da Silva WS, Christoffolete MA. |
Biosci Rep. 2005 Jun-Aug;25(3-4):191-208. (REVIEW) |
PMID 16283553 |
|
The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element. |
Buettner C, Harney JW, Larsen PR. |
J Biol Chem. 1998 Dec 11;273(50):33374-8. |
PMID 9837913 |
|
Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing. |
Campos-Barros A, Amma LL, Faris JS, Shailam R, Kelley MW, Forrest D. |
Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1287-92. |
PMID 10655523 |
|
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. |
Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL. |
J Clin Endocrinol Metab. 2005 Jun;90(6):3472-8. Epub 2005 Mar 29. |
PMID 15797963 |
|
Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients. |
Canani LH, Leie MA, Machado WE, Capp C, Maia AL. |
Hypertension. 2007 Jun;49(6):e47; author reply e48. Epub 2007 Mar 26. |
PMID 17389255 |
|
Genomic characterization of the coding region of the human type II 5'-deiodinase gene. |
Celi FS, Canettieri G, Yarnall DP, Burns DK, Andreoli M, Shuldiner AR, Centanni M. |
Mol Cell Endocrinol. 1998 Jun 25;141(1-2):49-52. |
PMID 9723885 |
|
Screening of SNPs at 18 positional candidate genes, located within the GD-1 locus on chromosome 14q23-q32, for susceptibility to Graves' disease: a TDT study. |
Chistiakov DA, Savost'anov KV, Turakulov RI. |
Mol Genet Metab. 2004 Nov;83(3):264-70. |
PMID 15542398 |
|
Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. |
Croteau W, Davey JC, Galton VA, St Germain DL. |
J Clin Invest. 1996 Jul 15;98(2):405-17. |
PMID 8755651 |
|
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. |
Curcio C, Baqui MM, Salvatore D, Rihn BH, Mohr S, Harney JW, Larsen PR, Bianco AC. |
J Biol Chem. 2001 Aug 10;276(32):30183-7. Epub 2001 Jun 25. |
PMID 11425850 |
|
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. |
Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC. |
J Clin Invest. 2003 Jul;112(2):189-96. |
PMID 12865408 |
|
Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome. |
Fiorito M, Torrente I, De Cosmo S, Guida V, Colosimo A, Prudente S, Flex E, Menghini R, Miccoli R, Penno G, Pellegrini F, Tassi V, Federici M, Trischitta V, Dallapiccola B. |
Obesity (Silver Spring). 2007 Dec;15(12):2889-95. |
PMID 18198294 |
|
The roles of the iodothyronine deiodinases in mammalian development. |
Galton VA. |
Thyroid. 2005 Aug;15(8):823-34. (REVIEW) |
PMID 16131325 |
|
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. |
Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeold A, Bianco AC. |
Endocr Rev. 2008 Dec;29(7):898-938. Epub 2008 Sep 24. (REVIEW) |
PMID 18815314 |
|
Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. |
Gouveia CH, Christoffolete MA, Zaitune CR, Dora JM, Harney JW, Maia AL, Bianco AC. |
Endocrinology. 2005 Jan;146(1):195-200. Epub 2004 Oct 7. |
PMID 15471965 |
|
Ala92 type 2 deiodinase allele increases risk for the development of hypertension. |
Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. |
Hypertension. 2007 Mar;49(3):461-6. Epub 2007 Jan 15. |
PMID 17224473 |
|
Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China. |
Guo TW, Zhang FC, Yang MS, Gao XC, Bian L, Duan SW, Zheng ZJ, Gao JJ, Wang H, Li RL, Feng GY, St Clair D, He L. |
J Med Genet. 2004 Aug;41(8):585-90. |
PMID 15286152 |
|
The type 2 deiodinase Thr92Ala polymorphism is associated with increased bone turnover and decreased femoral neck bone mineral density. |
Heemstra KA, Hoftijzer H, van der Deure WM, Peeters RP, Hamdy NA, Pereira A, Corssmit EP, Romijn JA, Visser TJ, Smit JW. |
J Bone Miner Res. 2010 Jun;25(6):1385-91. |
PMID 20200941 |
|
The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. |
Maia AL, Dupuis J, Manning A, Liu C, Meigs JB, Cupples LA, Larsen PR, Fox CS. |
Thyroid. 2007 Mar;17(3):199-202. |
PMID 17381351 |
|
Lack of association between the type 2 deiodinase A/G polymorphism and hypertensive traits: the Framingham Heart Study. |
Maia AL, Hwang SJ, Levy D, Larson MG, Larsen PR, Fox CS. |
Hypertension. 2008 Apr;51(4):e22-3. Epub 2008 Feb 19. |
PMID 18285610 |
|
Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. |
Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR. |
J Clin Invest. 2005 Sep;115(9):2524-33. Epub 2005 Aug 25. |
PMID 16127464 |
|
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. |
Mentuccia D, Proietti-Pannunzi L, Tanner K, Bacci V, Pollin TI, Poehlman ET, Shuldiner AR, Celi FS. |
Diabetes. 2002 Mar;51(3):880-3. |
PMID 11872697 |
|
Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma. |
Meyer EL, Goemann IM, Dora JM, Wagner MS, Maia AL. |
Mol Cell Endocrinol. 2008 Jul 16;289(1-2):16-22. Epub 2008 Apr 22. |
PMID 18514391 |
|
Thyroid hormone activation in human vascular smooth muscle cells: expression of type II iodothyronine deiodinase. |
Mizuma H, Murakami M, Mori M. |
Circ Res. 2001 Feb 16;88(3):313-8. |
PMID 11179199 |
|
Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin. |
Morimura T, Tsunekawa K, Kasahara T, Seki K, Ogiwara T, Mori M, Murakami M. |
Endocrinology. 2005 Apr;146(4):2077-84. Epub 2005 Jan 13. |
PMID 15650076 |
|
Thyrotropin receptors in brown adipose tissue: thyrotropin stimulates type II iodothyronine deiodinase and uncoupling protein-1 in brown adipocytes. |
Murakami M, Kamiya Y, Morimura T, Araki O, Imamura M, Ogiwara T, Mizuma H, Mori M. |
Endocrinology. 2001 Mar;142(3):1195-201. |
PMID 11181535 |
|
Identification of two novel splicing variants of human type II iodothyronine deiodinase mRNA. |
Ohba K, Yoshioka T, Muraki T. |
Mol Cell Endocrinol. 2001 Feb 14;172(1-2):169-75. |
PMID 11165050 |
|
Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. |
Panicker V, Saravanan P, Vaidya B, Evans J, Hattersley AT, Frayling TM, Dayan CM. |
J Clin Endocrinol Metab. 2009 May;94(5):1623-9. Epub 2009 Feb 3. |
PMID 19190113 |
|
Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. |
Sagar GD, Gereben B, Callebaut I, Mornon JP, Zeold A, da Silva WS, Luongo C, Dentice M, Tente SM, Freitas BC, Harney JW, Zavacki AM, Bianco AC. |
Mol Cell Biol. 2007 Jul;27(13):4774-83. Epub 2007 Apr 23. |
PMID 17452445 |
|
Type 2 iodothyronine deiodinase is highly expressed in human thyroid. |
Salvatore D, Tu H, Harney JW, Larsen PR. |
J Clin Invest. 1996 Aug 15;98(4):962-8. |
PMID 8770868 |
|
Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4. |
Schneider MJ, Fiering SN, Pallud SE, Parlow AF, St Germain DL, Galton VA. |
Mol Endocrinol. 2001 Dec;15(12):2137-48. |
PMID 11731615 |
|
Hypothyroidism induces type 2 iodothyronine deiodinase expression in mouse heart and testis. |
Wagner MS, Morimoto R, Dora JM, Benneman A, Pavan R, Maia AL. |
J Mol Endocrinol. 2003 Dec;31(3):541-50. |
PMID 14664714 |
|
Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis. |
Wajner SM, dos Santos Wagner M, Melo RC, Parreira GG, Chiarini-Garcia H, Bianco AC, Fekete C, Sanchez E, Lechan RM, Maia AL. |
J Endocrinol. 2007 Jul;194(1):47-54. |
PMID 17592020 |
|
Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy. |
Wang YY, Morimoto S, Du CK, Lu QW, Zhan DY, Tsutsumi T, Ide T, Miwa Y, Takahashi-Yanaga F, Sasaguri T. |
Cardiovasc Res. 2010 Jun 5. [Epub ahead of print] |
PMID 20453157 |
|
Cold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis. |
Watanabe M, Yamamoto T, Mori C, Okada N, Yamazaki N, Kajimoto K, Kataoka M, Shinohara Y. |
Biol Pharm Bull. 2008 May;31(5):775-84. (REVIEW) |
PMID 18451493 |
|
Iodothyronine deiodinase enzyme activities in bone. |
Williams AJ, Robson H, Kester MH, van Leeuwen JP, Shalet SM, Visser TJ, Williams GR. |
Bone. 2008 Jul;43(1):126-34. Epub 2008 Apr 4. |
PMID 18468505 |
|
[Thyroid hormones, obesity and brown adipose tissue thermogenesis]. |
Zaninovich AA. |
Medicina (B Aires). 2001;61(5 Pt 1):597-602. (REVIEW) |
PMID 11721329 |
|