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DIO3 (deiodinase, iodothyronine, type III)

Identity

Other names5DIII
D3
DIOIII
TXDI3
HGNC (Hugo) DIO3
LocusID (NCBI) 1735
Atlas_Id 40309
Location 14q32.31
Location_base_pair Starts at 102027688 and ends at 102029789 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DIO3   2885
Cards
Entrez_Gene (NCBI)DIO3  1735  deiodinase, iodothyronine, type III
GeneCards (Weizmann)DIO3
Ensembl hg19 (Hinxton)ENSG00000197406 [Gene_View]  chr14:102027688-102029789 [Contig_View]  DIO3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000197406 [Gene_View]  chr14:102027688-102029789 [Contig_View]  DIO3 [Vega]
ICGC DataPortalENSG00000197406
TCGA cBioPortalDIO3
AceView (NCBI)DIO3
Genatlas (Paris)DIO3
WikiGenes1735
SOURCE (Princeton)DIO3
Genomic and cartography
GoldenPath hg19 (UCSC)DIO3  -     chr14:102027688-102029789 +  14q32.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DIO3  -     14q32.31   [Description]    (hg38-Dec_2013)
EnsemblDIO3 - 14q32.31 [CytoView hg19]  DIO3 - 14q32.31 [CytoView hg38]
Mapping of homologs : NCBIDIO3 [Mapview hg19]  DIO3 [Mapview hg38]
OMIM601038   
Gene and transcription
Genbank (Entrez)BC017717 BX161470 S79854
RefSeq transcript (Entrez)NM_001362
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)DIO3
Cluster EST : UnigeneHs.49322 [ NCBI ]
CGAP (NCI)Hs.49322
Alternative Splicing : Fast-db (Paris)GSHG0009128
Alternative Splicing GalleryENSG00000197406
Gene ExpressionDIO3 [ NCBI-GEO ]     DIO3 [ SEEK ]   DIO3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55073 (Uniprot)
NextProtP55073  [Medical]
With graphics : InterProP55073
Splice isoforms : SwissVarP55073 (Swissvar)
Catalytic activity : Enzyme1.97.1.11 [ Enzyme-Expasy ]   1.97.1.111.97.1.11 [ IntEnz-EBI ]   1.97.1.11 [ BRENDA ]   1.97.1.11 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)T4_DEIODINASE (PS01205)   
Domains : Interpro (EBI)Iodothyronine_deiodinase    Iodothyronine_deiodinase_AS    Iodothyronine_deiodinase_I/III    Thioredoxin-like_fold   
Related proteins : CluSTrP55073
Domain families : Pfam (Sanger)T4_deiodinase (PF00837)   
Domain families : Pfam (NCBI)pfam00837   
DMDM Disease mutations1735
Blocks (Seattle)P55073
Human Protein AtlasENSG00000197406
Peptide AtlasP55073
HPRD11867
IPIIPI00296437   IPI00967699   
Protein Interaction databases
DIP (DOE-UCLA)P55073
IntAct (EBI)P55073
FunCoupENSG00000197406
BioGRIDDIO3
IntegromeDBDIO3
STRING (EMBL)DIO3
Ontologies - Pathways
QuickGOP55073
Ontology : AmiGOthyroxine 5'-deiodinase activity  plasma membrane  thyroid hormone generation  biological_process  endosome membrane  integral component of membrane  thyroxine 5-deiodinase activity  cellular nitrogen compound metabolic process  positive regulation of multicellular organism growth  thyroid hormone catabolic process  hormone biosynthetic process  small molecule metabolic process  oxidation-reduction process  
Ontology : EGO-EBIthyroxine 5'-deiodinase activity  plasma membrane  thyroid hormone generation  biological_process  endosome membrane  integral component of membrane  thyroxine 5-deiodinase activity  cellular nitrogen compound metabolic process  positive regulation of multicellular organism growth  thyroid hormone catabolic process  hormone biosynthetic process  small molecule metabolic process  oxidation-reduction process  
Pathways : KEGGThyroid hormone signaling pathway   
Protein Interaction DatabaseDIO3
DoCM (Curated mutations)DIO3
Wikipedia pathwaysDIO3
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerDIO3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DIO3
dbVarDIO3
ClinVarDIO3
1000_GenomesDIO3 
Exome Variant ServerDIO3
SNP (GeneSNP Utah)DIO3
SNP : HGBaseDIO3
Genetic variants : HAPMAPDIO3
Genomic Variants (DGV)DIO3 [DGVbeta]
Mutations
ICGC Data PortalDIO3 
TCGA Data PortalDIO3 
Tumor PortalDIO3
Somatic Mutations in Cancer : COSMICDIO3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:102027688-102029789
CONAN: Copy Number AnalysisDIO3 
Mutations and Diseases : HGMDDIO3
OMIM601038   
MedgenDIO3
NextProtP55073 [Medical]
GENETestsDIO3
Disease Genetic AssociationDIO3
Huge Navigator DIO3 [HugePedia]  DIO3 [HugeCancerGEM]
snp3D : Map Gene to Disease1735
DGIdb (Drug Gene Interaction db)DIO3
General knowledge
Homologs : HomoloGeneDIO3
Homology/Alignments : Family Browser (UCSC)DIO3
Phylogenetic Trees/Animal Genes : TreeFamDIO3
Chemical/Protein Interactions : CTD1735
Chemical/Pharm GKB GenePA27339
Clinical trialDIO3
Cancer Resource (Charite)ENSG00000197406
Other databases
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
CoreMineDIO3
GoPubMedDIO3
iHOPDIO3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 19:09:08 CEST 2015

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