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DIRAS1 (DIRAS family GTPase 1)

Identity

Alias (NCBI)Di-Ras1
GBTS1
RIG
HGNC (Hugo) DIRAS1
HGNC Alias symbDi-Ras1
GBTS1
RIG
HGNC Previous nameDIRAS family, GTP-binding RAS-like 1
LocusID (NCBI) 148252
Atlas_Id 40310
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2714567 and ends at 2721372 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DIRAS1   19127
Cards
Entrez_Gene (NCBI)DIRAS1    DIRAS family GTPase 1
AliasesDi-Ras1; GBTS1; RIG
GeneCards (Weizmann)DIRAS1
Ensembl hg19 (Hinxton)ENSG00000176490 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176490 [Gene_View]  ENSG00000176490 [Sequence]  chr19:2714567-2721372 [Contig_View]  DIRAS1 [Vega]
ICGC DataPortalENSG00000176490
TCGA cBioPortalDIRAS1
AceView (NCBI)DIRAS1
Genatlas (Paris)DIRAS1
SOURCE (Princeton)DIRAS1
Genetics Home Reference (NIH)DIRAS1
Genomic and cartography
GoldenPath hg38 (UCSC)DIRAS1  -     chr19:2714567-2721372 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DIRAS1  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathDIRAS1 - 19p13.3 [CytoView hg19]  DIRAS1 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000176490
Genome Data Viewer NCBIDIRAS1 [Mapview hg19]  
OMIM607862   
Gene and transcription
Genbank (Entrez)AB076888 AK124445 AK124672 AL833958 AY056037
RefSeq transcript (Entrez)NM_145173
Consensus coding sequences : CCDS (NCBI)DIRAS1
Gene ExpressionDIRAS1 [ NCBI-GEO ]   DIRAS1 [ EBI - ARRAY_EXPRESS ]   DIRAS1 [ SEEK ]   DIRAS1 [ MEM ]
Gene Expression Viewer (FireBrowse)DIRAS1 [ Firebrowse - Broad ]
GenevisibleExpression of DIRAS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)148252
GTEX Portal (Tissue expression)DIRAS1
Human Protein AtlasENSG00000176490-DIRAS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95057   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95057  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95057
PhosPhoSitePlusO95057
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras-type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)DIRAS1
PDB (RSDB)2GF0   
PDB Europe2GF0   
PDB (PDBSum)2GF0   
PDB (IMB)2GF0   
Structural Biology KnowledgeBase2GF0   
SCOP (Structural Classification of Proteins)2GF0   
CATH (Classification of proteins structures)2GF0   
SuperfamilyO95057
AlphaFold pdb e-kbO95057   
Human Protein Atlas [tissue]ENSG00000176490-DIRAS1 [tissue]
HPRD09710
Protein Interaction databases
DIP (DOE-UCLA)O95057
IntAct (EBI)O95057
BioGRIDDIRAS1
STRING (EMBL)DIRAS1
ZODIACDIRAS1
Ontologies - Pathways
QuickGOO95057
Ontology : AmiGOGTPase activity  GTPase activity  protein binding  GTP binding  GTP binding  plasma membrane  plasma membrane  signal transduction  GDP binding  positive regulation of MAP kinase activity  mitogen-activated protein kinase binding  
Ontology : EGO-EBIGTPase activity  GTPase activity  protein binding  GTP binding  GTP binding  plasma membrane  plasma membrane  signal transduction  GDP binding  positive regulation of MAP kinase activity  mitogen-activated protein kinase binding  
NDEx NetworkDIRAS1
Atlas of Cancer Signalling NetworkDIRAS1
Wikipedia pathwaysDIRAS1
Orthology - Evolution
OrthoDB148252
GeneTree (enSembl)ENSG00000176490
Phylogenetic Trees/Animal Genes : TreeFamDIRAS1
Homologs : HomoloGeneDIRAS1
Homology/Alignments : Family Browser (UCSC)DIRAS1
Gene fusions - Rearrangements
Fusion : QuiverDIRAS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDIRAS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DIRAS1
dbVarDIRAS1
ClinVarDIRAS1
MonarchDIRAS1
1000_GenomesDIRAS1 
Exome Variant ServerDIRAS1
GNOMAD BrowserENSG00000176490
Varsome BrowserDIRAS1
ACMGDIRAS1 variants
VarityO95057
Genomic Variants (DGV)DIRAS1 [DGVbeta]
DECIPHERDIRAS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDIRAS1 
Mutations
ICGC Data PortalDIRAS1 
TCGA Data PortalDIRAS1 
Broad Tumor PortalDIRAS1
OASIS PortalDIRAS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDIRAS1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDIRAS1
Mutations and Diseases : HGMDDIRAS1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDIRAS1
DgiDB (Drug Gene Interaction Database)DIRAS1
DoCM (Curated mutations)DIRAS1
CIViC (Clinical Interpretations of Variants in Cancer)DIRAS1
Cancer3DDIRAS1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607862   
Orphanet
DisGeNETDIRAS1
MedgenDIRAS1
Genetic Testing Registry DIRAS1
NextProtO95057 [Medical]
GENETestsDIRAS1
Target ValidationDIRAS1
Huge Navigator DIRAS1 [HugePedia]
ClinGenDIRAS1
Clinical trials, drugs, therapy
MyCancerGenomeDIRAS1
Protein Interactions : CTDDIRAS1
Pharm GKB GenePA134951835
PharosO95057
Clinical trialDIRAS1
Miscellaneous
canSAR (ICR)DIRAS1
HarmonizomeDIRAS1
DataMed IndexDIRAS1
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDIRAS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:46 CEST 2021

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