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DIRAS1 (DIRAS family GTPase 1)

Identity

Alias_namesDIRAS family
Alias_symbol (synonym)Di-Ras1
GBTS1
RIG
Other alias
HGNC (Hugo) DIRAS1
LocusID (NCBI) 148252
Atlas_Id 40310
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2714567 and ends at 2721392 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DIRAS1   19127
Cards
Entrez_Gene (NCBI)DIRAS1  148252  DIRAS family GTPase 1
AliasesDi-Ras1; GBTS1; RIG
GeneCards (Weizmann)DIRAS1
Ensembl hg19 (Hinxton)ENSG00000176490 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176490 [Gene_View]  chr19:2714567-2721392 [Contig_View]  DIRAS1 [Vega]
ICGC DataPortalENSG00000176490
TCGA cBioPortalDIRAS1
AceView (NCBI)DIRAS1
Genatlas (Paris)DIRAS1
WikiGenes148252
SOURCE (Princeton)DIRAS1
Genetics Home Reference (NIH)DIRAS1
Genomic and cartography
GoldenPath hg38 (UCSC)DIRAS1  -     chr19:2714567-2721392 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DIRAS1  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblDIRAS1 - 19p13.3 [CytoView hg19]  DIRAS1 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIDIRAS1 [Mapview hg19]  DIRAS1 [Mapview hg38]
OMIM607862   
Gene and transcription
Genbank (Entrez)AB076888 AK124445 AK124672 AL833958 AY056037
RefSeq transcript (Entrez)NM_145173
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DIRAS1
Cluster EST : UnigeneHs.172753 [ NCBI ]
CGAP (NCI)Hs.172753
Alternative Splicing GalleryENSG00000176490
Gene ExpressionDIRAS1 [ NCBI-GEO ]   DIRAS1 [ EBI - ARRAY_EXPRESS ]   DIRAS1 [ SEEK ]   DIRAS1 [ MEM ]
Gene Expression Viewer (FireBrowse)DIRAS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)148252
GTEX Portal (Tissue expression)DIRAS1
Human Protein AtlasENSG00000176490-DIRAS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95057   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95057  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95057
Splice isoforms : SwissVarO95057
PhosPhoSitePlusO95057
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)DIRAS1
DMDM Disease mutations148252
Blocks (Seattle)DIRAS1
PDB (SRS)2GF0   
PDB (PDBSum)2GF0   
PDB (IMB)2GF0   
PDB (RSDB)2GF0   
Structural Biology KnowledgeBase2GF0   
SCOP (Structural Classification of Proteins)2GF0   
CATH (Classification of proteins structures)2GF0   
SuperfamilyO95057
Human Protein Atlas [tissue]ENSG00000176490-DIRAS1 [tissue]
Peptide AtlasO95057
HPRD09710
IPIIPI00002919   IPI00982624   
Protein Interaction databases
DIP (DOE-UCLA)O95057
IntAct (EBI)O95057
FunCoupENSG00000176490
BioGRIDDIRAS1
STRING (EMBL)DIRAS1
ZODIACDIRAS1
Ontologies - Pathways
QuickGOO95057
Ontology : AmiGOGTPase activity  GTP binding  plasma membrane  signal transduction  positive regulation of MAP kinase activity  mitogen-activated protein kinase binding  
Ontology : EGO-EBIGTPase activity  GTP binding  plasma membrane  signal transduction  positive regulation of MAP kinase activity  mitogen-activated protein kinase binding  
NDEx NetworkDIRAS1
Atlas of Cancer Signalling NetworkDIRAS1
Wikipedia pathwaysDIRAS1
Orthology - Evolution
OrthoDB148252
GeneTree (enSembl)ENSG00000176490
Phylogenetic Trees/Animal Genes : TreeFamDIRAS1
HOVERGENO95057
HOGENOMO95057
Homologs : HomoloGeneDIRAS1
Homology/Alignments : Family Browser (UCSC)DIRAS1
Gene fusions - Rearrangements
Tumor Fusion PortalDIRAS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDIRAS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DIRAS1
dbVarDIRAS1
ClinVarDIRAS1
1000_GenomesDIRAS1 
Exome Variant ServerDIRAS1
ExAC (Exome Aggregation Consortium)ENSG00000176490
GNOMAD BrowserENSG00000176490
Genetic variants : HAPMAP148252
Genomic Variants (DGV)DIRAS1 [DGVbeta]
DECIPHERDIRAS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDIRAS1 
Mutations
ICGC Data PortalDIRAS1 
TCGA Data PortalDIRAS1 
Broad Tumor PortalDIRAS1
OASIS PortalDIRAS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDIRAS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDIRAS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DIRAS1
DgiDB (Drug Gene Interaction Database)DIRAS1
DoCM (Curated mutations)DIRAS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DIRAS1 (select a term)
intoGenDIRAS1
Cancer3DDIRAS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607862   
Orphanet
DisGeNETDIRAS1
MedgenDIRAS1
Genetic Testing Registry DIRAS1
NextProtO95057 [Medical]
TSGene148252
GENETestsDIRAS1
Target ValidationDIRAS1
Huge Navigator DIRAS1 [HugePedia]
snp3D : Map Gene to Disease148252
BioCentury BCIQDIRAS1
ClinGenDIRAS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD148252
Chemical/Pharm GKB GenePA134951835
Clinical trialDIRAS1
Miscellaneous
canSAR (ICR)DIRAS1 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDIRAS1
EVEXDIRAS1
GoPubMedDIRAS1
iHOPDIRAS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:10:36 CET 2017

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