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DIRAS2 (DIRAS family GTPase 2)

Identity

Alias (NCBI)Di-Ras2
HGNC (Hugo) DIRAS2
HGNC Alias symbDi-Ras2
DKFZp761C07121
HGNC Previous nameDIRAS family, GTP-binding RAS-like 2
LocusID (NCBI) 54769
Atlas_Id 43230
Location 9q22.2  [Link to chromosome band 9q22]
Location_base_pair Starts at 90609832 and ends at 90642824 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DIRAS2 (9q22.2) / COMMD1 (2p15)DIRAS2 (9q22.2) / DIRAS2 (9q22.2)DIRAS2 (9q22.2) / GNA14 (9q21.2)
DIRAS2 9q22.2 / GNA14 9q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DIRAS2   19323
Cards
Entrez_Gene (NCBI)DIRAS2    DIRAS family GTPase 2
AliasesDi-Ras2
GeneCards (Weizmann)DIRAS2
Ensembl hg19 (Hinxton)ENSG00000165023 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165023 [Gene_View]  ENSG00000165023 [Sequence]  chr9:90609832-90642824 [Contig_View]  DIRAS2 [Vega]
ICGC DataPortalENSG00000165023
TCGA cBioPortalDIRAS2
AceView (NCBI)DIRAS2
Genatlas (Paris)DIRAS2
SOURCE (Princeton)DIRAS2
Genetics Home Reference (NIH)DIRAS2
Genomic and cartography
GoldenPath hg38 (UCSC)DIRAS2  -     chr9:90609832-90642824 -  9q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DIRAS2  -     9q22.2   [Description]    (hg19-Feb_2009)
GoldenPathDIRAS2 - 9q22.2 [CytoView hg19]  DIRAS2 - 9q22.2 [CytoView hg38]
ImmunoBaseENSG00000165023
Genome Data Viewer NCBIDIRAS2 [Mapview hg19]  
OMIM607863   
Gene and transcription
Genbank (Entrez)AB076889 AK122986 AK124628 AL137308 BC008065
RefSeq transcript (Entrez)NM_017594
Consensus coding sequences : CCDS (NCBI)DIRAS2
Gene ExpressionDIRAS2 [ NCBI-GEO ]   DIRAS2 [ EBI - ARRAY_EXPRESS ]   DIRAS2 [ SEEK ]   DIRAS2 [ MEM ]
Gene Expression Viewer (FireBrowse)DIRAS2 [ Firebrowse - Broad ]
GenevisibleExpression of DIRAS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54769
GTEX Portal (Tissue expression)DIRAS2
Human Protein AtlasENSG00000165023-DIRAS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HU8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HU8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HU8
PhosPhoSitePlusQ96HU8
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras-type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)DIRAS2
PDB (RSDB)2ERX    6NAZ   
PDB Europe2ERX    6NAZ   
PDB (PDBSum)2ERX    6NAZ   
PDB (IMB)2ERX    6NAZ   
Structural Biology KnowledgeBase2ERX    6NAZ   
SCOP (Structural Classification of Proteins)2ERX    6NAZ   
CATH (Classification of proteins structures)2ERX    6NAZ   
SuperfamilyQ96HU8
AlphaFold pdb e-kbQ96HU8   
Human Protein Atlas [tissue]ENSG00000165023-DIRAS2 [tissue]
HPRD09711
Protein Interaction databases
DIP (DOE-UCLA)Q96HU8
IntAct (EBI)Q96HU8
BioGRIDDIRAS2
STRING (EMBL)DIRAS2
ZODIACDIRAS2
Ontologies - Pathways
QuickGOQ96HU8
Ontology : AmiGOGTPase activity  protein binding  GTP binding  GTP binding  plasma membrane  plasma membrane  signal transduction  GDP binding  positive regulation of MAP kinase activity  
Ontology : EGO-EBIGTPase activity  protein binding  GTP binding  GTP binding  plasma membrane  plasma membrane  signal transduction  GDP binding  positive regulation of MAP kinase activity  
NDEx NetworkDIRAS2
Atlas of Cancer Signalling NetworkDIRAS2
Wikipedia pathwaysDIRAS2
Orthology - Evolution
OrthoDB54769
GeneTree (enSembl)ENSG00000165023
Phylogenetic Trees/Animal Genes : TreeFamDIRAS2
Homologs : HomoloGeneDIRAS2
Homology/Alignments : Family Browser (UCSC)DIRAS2
Gene fusions - Rearrangements
Fusion : MitelmanDIRAS2/GNA14 [9q22.2/9q21.2]  
Fusion : QuiverDIRAS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDIRAS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DIRAS2
dbVarDIRAS2
ClinVarDIRAS2
MonarchDIRAS2
1000_GenomesDIRAS2 
Exome Variant ServerDIRAS2
GNOMAD BrowserENSG00000165023
Varsome BrowserDIRAS2
ACMGDIRAS2 variants
VarityQ96HU8
Genomic Variants (DGV)DIRAS2 [DGVbeta]
DECIPHERDIRAS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDIRAS2 
Mutations
ICGC Data PortalDIRAS2 
TCGA Data PortalDIRAS2 
Broad Tumor PortalDIRAS2
OASIS PortalDIRAS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDIRAS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDIRAS2
Mutations and Diseases : HGMDDIRAS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDIRAS2
DgiDB (Drug Gene Interaction Database)DIRAS2
DoCM (Curated mutations)DIRAS2
CIViC (Clinical Interpretations of Variants in Cancer)DIRAS2
Cancer3DDIRAS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607863   
Orphanet
DisGeNETDIRAS2
MedgenDIRAS2
Genetic Testing Registry DIRAS2
NextProtQ96HU8 [Medical]
GENETestsDIRAS2
Target ValidationDIRAS2
Huge Navigator DIRAS2 [HugePedia]
ClinGenDIRAS2
Clinical trials, drugs, therapy
MyCancerGenomeDIRAS2
Protein Interactions : CTDDIRAS2
Pharm GKB GenePA134958969
PharosQ96HU8
Clinical trialDIRAS2
Miscellaneous
canSAR (ICR)DIRAS2
HarmonizomeDIRAS2
DataMed IndexDIRAS2
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDIRAS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:46 CEST 2021

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