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DIRC1 (disrupted in renal carcinoma 1)

Written2004-06Anita Bonné, Eric Schoenmakers, Ad Geurts van Kessel
Department of Human Genetics (417), P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

(Note : for Links provided by Atlas : click)

Identity

Other alias
LocusID (NCBI) 116093
Atlas_Id 499
Location 2q32.2  [Link to chromosome band 2q32]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DIRC1 (2q32.2) / RCC1 (1p35.3)RCC1 (1p35.3) / DIRC1 (2q32.2)

DNA/RNA

Description The DIRC1 gene contains 2 exons and spans approximately 57 kb of genomic DNA

Protein

Description 104 amino acids
Expression Expression in adult placenta, testis, ovary, prostate, and in fetal kidney, spleen, and skeletal muscle.
Function unknown

Implicated in

Note
  
Entity t(2;3)(q33;q21) in hereditary renal cell cancer.
Disease Familial renal cell cancer.
Cytogenetics Disruption of the gene because of the t(2;3) translocation.
  

Bibliography

The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation.
Druck T, Podolski J, Byrski T, Wyrwicz L, Zajaczek S, Kata G, Borowka A, Lubinski J, Huebner K
Journal of human genetics. 2001 ; 46 (10) : 583-589.
PMID 11587072
 
Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation.
Podolski J, Byrski T, Zajaczek S, Druck T, Zimonjic DB, Popescu NC, Kata G, Borowka A, Gronwald J, Lubinski J, Huebner K
Journal of human genetics. 2001 ; 46 (12) : 685-693.
PMID 11776380
 

Citation

This paper should be referenced as such :
Bonné, A ; Schoenmakers, EFPMG ; Geurts, van Kessel A
DIRC1 (disrupted in renal carcinoma 1)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):211-211.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/DIRC1ID499.html


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Familial clear cell renal cancer


External links

Nomenclature
Cards
AtlasDIRC1ID499.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)116093
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:33:49 CEST 2018

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