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DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease)

Identity

Alias_namesKIAA1008
KIAA1008
DIS3 mitotic control homolog (S. cerevisiae)
Alias_symbol (synonym)dis3p
RRP44
EXOSC11
Other alias2810028N01Rik
HGNC (Hugo) DIS3
LocusID (NCBI) 22894
Atlas_Id 53556
Location 13q21.33  [Link to chromosome band 13q21]
Location_base_pair Starts at 72755402 and ends at 72782128 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BORA (13q22.1) / DIS3 (13q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DIS3   20604
Cards
Entrez_Gene (NCBI)DIS3  22894  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Aliases2810028N01Rik; EXOSC11; KIAA1008; RRP44; 
dis3p
GeneCards (Weizmann)DIS3
Ensembl hg19 (Hinxton)ENSG00000083520 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000083520 [Gene_View]  chr13:72755402-72782128 [Contig_View]  DIS3 [Vega]
ICGC DataPortalENSG00000083520
TCGA cBioPortalDIS3
AceView (NCBI)DIS3
Genatlas (Paris)DIS3
WikiGenes22894
SOURCE (Princeton)DIS3
Genetics Home Reference (NIH)DIS3
Genomic and cartography
GoldenPath hg38 (UCSC)DIS3  -     chr13:72755402-72782128 -  13q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DIS3  -     13q21.33   [Description]    (hg19-Feb_2009)
EnsemblDIS3 - 13q21.33 [CytoView hg19]  DIS3 - 13q21.33 [CytoView hg38]
Mapping of homologs : NCBIDIS3 [Mapview hg19]  DIS3 [Mapview hg38]
OMIM607533   
Gene and transcription
Genbank (Entrez)AB001743 AB023225 AF035310 AF330044 AK001346
RefSeq transcript (Entrez)NM_001128226 NM_001322348 NM_001322349 NM_014953
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DIS3
Cluster EST : UnigeneHs.744104 [ NCBI ]
CGAP (NCI)Hs.744104
Alternative Splicing GalleryENSG00000083520
Gene ExpressionDIS3 [ NCBI-GEO ]   DIS3 [ EBI - ARRAY_EXPRESS ]   DIS3 [ SEEK ]   DIS3 [ MEM ]
Gene Expression Viewer (FireBrowse)DIS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22894
GTEX Portal (Tissue expression)DIS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2L1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2L1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2L1
Splice isoforms : SwissVarQ9Y2L1
Catalytic activity : Enzyme3.1.13.- [ Enzyme-Expasy ]   3.1.13.-3.1.13.- [ IntEnz-EBI ]   3.1.13.- [ BRENDA ]   3.1.13.- [ KEGG ]   
PhosPhoSitePlusQ9Y2L1
Domaine pattern : Prosite (Expaxy)RIBONUCLEASE_II (PS01175)   
Domains : Interpro (EBI)NA-bd_OB-fold    PIN_dom    PIN_domain-like    RNase_II/R_CS    Rrp44_CSD1    RRP44_S1   
Domain families : Pfam (Sanger)PIN_4 (PF13638)    Rrp44_CSD1 (PF17216)    Rrp44_S1 (PF17215)   
Domain families : Pfam (NCBI)pfam13638    pfam17216    pfam17215   
Domain families : Smart (EMBL)PINc (SM00670)  
Conserved Domain (NCBI)DIS3
DMDM Disease mutations22894
Blocks (Seattle)DIS3
SuperfamilyQ9Y2L1
Human Protein AtlasENSG00000083520
Peptide AtlasQ9Y2L1
HPRD06338
IPIIPI00746351   IPI00183462   IPI01011589   IPI00978109   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2L1
IntAct (EBI)Q9Y2L1
FunCoupENSG00000083520
BioGRIDDIS3
STRING (EMBL)DIS3
ZODIACDIS3
Ontologies - Pathways
QuickGOQ9Y2L1
Ontology : AmiGO3'-5'-exoribonuclease activity  3'-5'-exoribonuclease activity  nuclear exosome (RNase complex)  exosome (RNase complex)  RNA binding  endonuclease activity  guanyl-nucleotide exchange factor activity  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cytosol  rRNA processing  membrane  rRNA catabolic process  regulation of mRNA stability  positive regulation of GTPase activity  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  CUT catabolic process  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  3'-5'-exoribonuclease activity  nuclear exosome (RNase complex)  exosome (RNase complex)  RNA binding  endonuclease activity  guanyl-nucleotide exchange factor activity  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cytosol  rRNA processing  membrane  rRNA catabolic process  regulation of mRNA stability  positive regulation of GTPase activity  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  CUT catabolic process  RNA phosphodiester bond hydrolysis, exonucleolytic  
Pathways : KEGGRNA degradation   
NDEx NetworkDIS3
Atlas of Cancer Signalling NetworkDIS3
Wikipedia pathwaysDIS3
Orthology - Evolution
OrthoDB22894
GeneTree (enSembl)ENSG00000083520
Phylogenetic Trees/Animal Genes : TreeFamDIS3
HOVERGENQ9Y2L1
HOGENOMQ9Y2L1
Homologs : HomoloGeneDIS3
Homology/Alignments : Family Browser (UCSC)DIS3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDIS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DIS3
dbVarDIS3
ClinVarDIS3
1000_GenomesDIS3 
Exome Variant ServerDIS3
ExAC (Exome Aggregation Consortium)DIS3 (select the gene name)
Genetic variants : HAPMAP22894
Genomic Variants (DGV)DIS3 [DGVbeta]
DECIPHERDIS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDIS3 
Mutations
ICGC Data PortalDIS3 
TCGA Data PortalDIS3 
Broad Tumor PortalDIS3
OASIS PortalDIS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDIS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDIS3
intOGen PortalDIS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DIS3
DgiDB (Drug Gene Interaction Database)DIS3
DoCM (Curated mutations)DIS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DIS3 (select a term)
intoGenDIS3
Cancer3DDIS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607533   
Orphanet
MedgenDIS3
Genetic Testing Registry DIS3
NextProtQ9Y2L1 [Medical]
TSGene22894
GENETestsDIS3
Target ValidationDIS3
Huge Navigator DIS3 [HugePedia]
snp3D : Map Gene to Disease22894
BioCentury BCIQDIS3
ClinGenDIS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22894
Chemical/Pharm GKB GenePA162383628
Clinical trialDIS3
Miscellaneous
canSAR (ICR)DIS3 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDIS3
EVEXDIS3
GoPubMedDIS3
iHOPDIS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:31:12 CEST 2017

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