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DIS3L (DIS3 like exosome 3'-5' exoribonuclease)

Identity

Alias_namesDIS3 mitotic control homolog (S. cerevisiae)-like
Alias_symbol (synonym)MGC4562
FLJ38088
KIAA1955
DIS3L1
Other alias
HGNC (Hugo) DIS3L
LocusID (NCBI) 115752
Atlas_Id 62489
Location 15q22.31  [Link to chromosome band 15q22]
Location_base_pair Starts at 66293575 and ends at 66333898 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DIS3L (15q22.31) / CBX3 (7p15.2)DIS3L (15q22.31) / LEPROT (1p31.3)SMAD3 (15q22.33) / DIS3L (15q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DIS3L   28698
Cards
Entrez_Gene (NCBI)DIS3L  115752  DIS3 like exosome 3'-5' exoribonuclease
AliasesDIS3L1
GeneCards (Weizmann)DIS3L
Ensembl hg19 (Hinxton)ENSG00000166938 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166938 [Gene_View]  chr15:66293575-66333898 [Contig_View]  DIS3L [Vega]
ICGC DataPortalENSG00000166938
TCGA cBioPortalDIS3L
AceView (NCBI)DIS3L
Genatlas (Paris)DIS3L
WikiGenes115752
SOURCE (Princeton)DIS3L
Genetics Home Reference (NIH)DIS3L
Genomic and cartography
GoldenPath hg38 (UCSC)DIS3L  -     chr15:66293575-66333898 +  15q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DIS3L  -     15q22.31   [Description]    (hg19-Feb_2009)
EnsemblDIS3L - 15q22.31 [CytoView hg19]  DIS3L - 15q22.31 [CytoView hg38]
Mapping of homologs : NCBIDIS3L [Mapview hg19]  DIS3L [Mapview hg38]
OMIM614183   
Gene and transcription
Genbank (Entrez)AB075835 AF147431 AK095407 AK123202 AK295392
RefSeq transcript (Entrez)NM_001143688 NM_001323936 NM_001323937 NM_001323938 NM_001323939 NM_001323940 NM_001323941 NM_001323943 NM_001323944 NM_001323945 NM_001323946 NM_001323948 NM_133375
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DIS3L
Cluster EST : UnigeneHs.658492 [ NCBI ]
CGAP (NCI)Hs.658492
Alternative Splicing GalleryENSG00000166938
Gene ExpressionDIS3L [ NCBI-GEO ]   DIS3L [ EBI - ARRAY_EXPRESS ]   DIS3L [ SEEK ]   DIS3L [ MEM ]
Gene Expression Viewer (FireBrowse)DIS3L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115752
GTEX Portal (Tissue expression)DIS3L
Human Protein AtlasENSG00000166938-DIS3L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TF46   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TF46  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TF46
Splice isoforms : SwissVarQ8TF46
PhosPhoSitePlusQ8TF46
Domaine pattern : Prosite (Expaxy)RIBONUCLEASE_II (PS01175)   
Domains : Interpro (EBI)DIS3L    NA-bd_OB-fold    RNase_II/R_CS    Rrp44_CSD1    RRP44_S1   
Domain families : Pfam (Sanger)Rrp44_CSD1 (PF17216)    Rrp44_S1 (PF17215)   
Domain families : Pfam (NCBI)pfam17216    pfam17215   
Conserved Domain (NCBI)DIS3L
DMDM Disease mutations115752
Blocks (Seattle)DIS3L
SuperfamilyQ8TF46
Human Protein Atlas [tissue]ENSG00000166938-DIS3L [tissue]
Peptide AtlasQ8TF46
HPRD11355
IPIIPI00879677   IPI00879828   IPI00295876   IPI00291003   IPI00909911   IPI00978250   IPI00979018   IPI01009000   IPI00977021   
Protein Interaction databases
DIP (DOE-UCLA)Q8TF46
IntAct (EBI)Q8TF46
FunCoupENSG00000166938
BioGRIDDIS3L
STRING (EMBL)DIS3L
ZODIACDIS3L
Ontologies - Pathways
QuickGOQ8TF46
Ontology : AmiGO3'-5'-exoribonuclease activity  3'-5'-exoribonuclease activity  cytoplasmic exosome (RNase complex)  RNA binding  protein binding  centrosome  cytosol  plasma membrane  rRNA processing  rRNA catabolic process  rRNA catabolic process  enzyme binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  3'-5'-exoribonuclease activity  cytoplasmic exosome (RNase complex)  RNA binding  protein binding  centrosome  cytosol  plasma membrane  rRNA processing  rRNA catabolic process  rRNA catabolic process  enzyme binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
Pathways : KEGGRNA degradation   
NDEx NetworkDIS3L
Atlas of Cancer Signalling NetworkDIS3L
Wikipedia pathwaysDIS3L
Orthology - Evolution
OrthoDB115752
GeneTree (enSembl)ENSG00000166938
Phylogenetic Trees/Animal Genes : TreeFamDIS3L
HOVERGENQ8TF46
HOGENOMQ8TF46
Homologs : HomoloGeneDIS3L
Homology/Alignments : Family Browser (UCSC)DIS3L
Gene fusions - Rearrangements
Fusion: Tumor Portal DIS3L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDIS3L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DIS3L
dbVarDIS3L
ClinVarDIS3L
1000_GenomesDIS3L 
Exome Variant ServerDIS3L
ExAC (Exome Aggregation Consortium)ENSG00000166938
GNOMAD BrowserENSG00000166938
Genetic variants : HAPMAP115752
Genomic Variants (DGV)DIS3L [DGVbeta]
DECIPHERDIS3L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDIS3L 
Mutations
ICGC Data PortalDIS3L 
TCGA Data PortalDIS3L 
Broad Tumor PortalDIS3L
OASIS PortalDIS3L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDIS3L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDIS3L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DIS3L
DgiDB (Drug Gene Interaction Database)DIS3L
DoCM (Curated mutations)DIS3L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DIS3L (select a term)
intoGenDIS3L
Cancer3DDIS3L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614183   
Orphanet
MedgenDIS3L
Genetic Testing Registry DIS3L
NextProtQ8TF46 [Medical]
TSGene115752
GENETestsDIS3L
Target ValidationDIS3L
Huge Navigator DIS3L [HugePedia]
snp3D : Map Gene to Disease115752
BioCentury BCIQDIS3L
ClinGenDIS3L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115752
Chemical/Pharm GKB GenePA162383675
Clinical trialDIS3L
Miscellaneous
canSAR (ICR)DIS3L (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDIS3L
EVEXDIS3L
GoPubMedDIS3L
iHOPDIS3L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 11:44:39 CET 2017

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