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DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)

Identity

Alias (NCBI)FAM6A
PRLMNS
hDIS3L2
HGNC (Hugo) DIS3L2
HGNC Alias symbFLJ36974
MGC42174
HGNC Previous nameFAM6A
HGNC Previous namefamily with sequence similarity 6, member A
 DIS3 mitotic control homolog (S. cerevisiae)-like 2
LocusID (NCBI) 129563
Atlas_Id 52692
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 231961713 and ends at 232337192 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF11 (1q23.1)::DIS3L2 (2q37.1)ARID5B (10q21.2)::DIS3L2 (2q37.1)DIS3L2 (2q37.1)::FAM124B (2q36.2)
DIS3L2 (2q37.1)::SPHKAP (2q36.3)DIS3L2 (2q37.1)::UBE2E3 (2q31.3)EIF4E2 (2q37.1)::DIS3L2 (2q37.1)
GIGYF2 (2q37.1)::DIS3L2 (2q37.1)DIS3L2 2q37.1::FAM124B 2q36.2DIS3L2 2q37.1::SPHKAP 2q36.3
DIS3L2 2q37.1::UBE2E3 2q31.3EIF4E2 2q37.1::DIS3L2 2q37.1GIGYF2 2q37.1::DIS3L2 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Perlman syndrome (renal hamartomas, nephroblastomatosis and fetal gigantism)


External links

 

Nomenclature
HGNC (Hugo)DIS3L2   28648
LRG (Locus Reference Genomic)LRG_534
Cards
Entrez_Gene (NCBI)DIS3L2    DIS3 like 3'-5' exoribonuclease 2
AliasesFAM6A; PRLMNS; hDIS3L2
GeneCards (Weizmann)DIS3L2
Ensembl hg19 (Hinxton)ENSG00000144535 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144535 [Gene_View]  ENSG00000144535 [Sequence]  chr2:231961713-232337192 [Contig_View]  DIS3L2 [Vega]
ICGC DataPortalENSG00000144535
TCGA cBioPortalDIS3L2
AceView (NCBI)DIS3L2
Genatlas (Paris)DIS3L2
SOURCE (Princeton)DIS3L2
Genetics Home Reference (NIH)DIS3L2
Genomic and cartography
GoldenPath hg38 (UCSC)DIS3L2  -     chr2:231961713-232337192 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DIS3L2  -     2q37.1   [Description]    (hg19-Feb_2009)
GoldenPathDIS3L2 - 2q37.1 [CytoView hg19]  DIS3L2 - 2q37.1 [CytoView hg38]
ImmunoBaseENSG00000144535
Genome Data Viewer NCBIDIS3L2 [Mapview hg19]  
OMIM267000   614184   
Gene and transcription
Genbank (Entrez)AA781347 AF443854 AK090419 AK094293 AK295363
RefSeq transcript (Entrez)NM_001257281 NM_001257282 NM_152383
Consensus coding sequences : CCDS (NCBI)DIS3L2
Gene ExpressionDIS3L2 [ NCBI-GEO ]   DIS3L2 [ EBI - ARRAY_EXPRESS ]   DIS3L2 [ SEEK ]   DIS3L2 [ MEM ]
Gene Expression Viewer (FireBrowse)DIS3L2 [ Firebrowse - Broad ]
GenevisibleExpression of DIS3L2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)129563
GTEX Portal (Tissue expression)DIS3L2
Human Protein AtlasENSG00000144535-DIS3L2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYB7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYB7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYB7
PhosPhoSitePlusQ8IYB7
Domaine pattern : Prosite (Expaxy)RIBONUCLEASE_II (PS01175)   
Domains : Interpro (EBI)Dis3_CSD2    DIS3L2    Dis3l2_C    NA-bd_OB-fold    RNase_II/R    RNase_II/R_CS    Rrp44_CSD1   
Domain families : Pfam (Sanger)Dis3l2_C_term (PF17877)    OB_Dis3 (PF17849)    RNB (PF00773)    Rrp44_CSD1 (PF17216)   
Domain families : Pfam (NCBI)pfam17877    pfam17849    pfam00773    pfam17216   
Domain families : Smart (EMBL)RNB (SM00955)  
Conserved Domain (NCBI)DIS3L2
SuperfamilyQ8IYB7
AlphaFold pdb e-kbQ8IYB7   
Human Protein Atlas [tissue]ENSG00000144535-DIS3L2 [tissue]
HPRD14619
Protein Interaction databases
DIP (DOE-UCLA)Q8IYB7
IntAct (EBI)Q8IYB7
BioGRIDDIS3L2
STRING (EMBL)DIS3L2
ZODIACDIS3L2
Ontologies - Pathways
QuickGOQ8IYB7
Ontology : AmiGO3'-5'-exoribonuclease activity  3'-5'-exoribonuclease activity  exosome (RNase complex)  mitotic cell cycle  magnesium ion binding  nuclear-transcribed mRNA catabolic process, exonucleolytic  P-body  P-body  ribonuclease activity  protein binding  cytoplasm  polysome  mRNA catabolic process  poly(U) RNA binding  negative regulation of cell population proliferation  miRNA catabolic process  miRNA catabolic process  miRNA catabolic process  stem cell population maintenance  nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'  cell division  mitotic sister chromatid separation  RNA phosphodiester bond hydrolysis, exonucleolytic  polyuridylation-dependent mRNA catabolic process  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  3'-5'-exoribonuclease activity  exosome (RNase complex)  mitotic cell cycle  magnesium ion binding  nuclear-transcribed mRNA catabolic process, exonucleolytic  P-body  P-body  ribonuclease activity  protein binding  cytoplasm  polysome  mRNA catabolic process  poly(U) RNA binding  negative regulation of cell population proliferation  miRNA catabolic process  miRNA catabolic process  miRNA catabolic process  stem cell population maintenance  nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'  cell division  mitotic sister chromatid separation  RNA phosphodiester bond hydrolysis, exonucleolytic  polyuridylation-dependent mRNA catabolic process  
NDEx NetworkDIS3L2
Atlas of Cancer Signalling NetworkDIS3L2
Wikipedia pathwaysDIS3L2
Orthology - Evolution
OrthoDB129563
GeneTree (enSembl)ENSG00000144535
Phylogenetic Trees/Animal Genes : TreeFamDIS3L2
Homologs : HomoloGeneDIS3L2
Homology/Alignments : Family Browser (UCSC)DIS3L2
Gene fusions - Rearrangements
Fusion : MitelmanDIS3L2::FAM124B [2q37.1/2q36.2]  
Fusion : MitelmanDIS3L2::SPHKAP [2q37.1/2q36.3]  
Fusion : MitelmanDIS3L2::UBE2E3 [2q37.1/2q31.3]  
Fusion : MitelmanEIF4E2::DIS3L2 [2q37.1/2q37.1]  
Fusion : MitelmanGIGYF2::DIS3L2 [2q37.1/2q37.1]  
Fusion : QuiverDIS3L2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDIS3L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DIS3L2
dbVarDIS3L2
ClinVarDIS3L2
MonarchDIS3L2
1000_GenomesDIS3L2 
Exome Variant ServerDIS3L2
GNOMAD BrowserENSG00000144535
Varsome BrowserDIS3L2
ACMGDIS3L2 variants
VarityQ8IYB7
Genomic Variants (DGV)DIS3L2 [DGVbeta]
DECIPHERDIS3L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDIS3L2 
Mutations
ICGC Data PortalDIS3L2 
TCGA Data PortalDIS3L2 
Broad Tumor PortalDIS3L2
OASIS PortalDIS3L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDIS3L2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDIS3L2
Mutations and Diseases : HGMDDIS3L2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDIS3L2
DgiDB (Drug Gene Interaction Database)DIS3L2
DoCM (Curated mutations)DIS3L2
CIViC (Clinical Interpretations of Variants in Cancer)DIS3L2
Cancer3DDIS3L2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM267000    614184   
Orphanet852    3474   
DisGeNETDIS3L2
MedgenDIS3L2
Genetic Testing Registry DIS3L2
NextProtQ8IYB7 [Medical]
GENETestsDIS3L2
Target ValidationDIS3L2
Huge Navigator DIS3L2 [HugePedia]
ClinGenDIS3L2
Clinical trials, drugs, therapy
MyCancerGenomeDIS3L2
Protein Interactions : CTDDIS3L2
Pharm GKB GenePA162383714
PharosQ8IYB7
Clinical trialDIS3L2
Miscellaneous
canSAR (ICR)DIS3L2
HarmonizomeDIS3L2
ARCHS4DIS3L2
DataMed IndexDIS3L2
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDIS3L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:30:37 CET 2022

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