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DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)

Identity

Alias_namesFAM6A
family with sequence similarity 6, member A
DIS3 mitotic control homolog (S. cerevisiae)-like 2
Alias_symbol (synonym)FLJ36974
MGC42174
Other aliasPRLMNS
hDIS3L2
HGNC (Hugo) DIS3L2
LocusID (NCBI) 129563
Atlas_Id 52692
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 232826293 and ends at 233208678 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGEF11 (1q23.1) / DIS3L2 (2q37.1)ARID5B (10q21.2) / DIS3L2 (2q37.1)DIS3L2 (2q37.1) / FAM124B (2q36.2)
DIS3L2 (2q37.1) / SPHKAP (2q36.3)DIS3L2 (2q37.1) / UBE2E3 (2q31.3)EIF4E2 (2q37.1) / DIS3L2 (2q37.1)
GIGYF2 (2q37.1) / DIS3L2 (2q37.1)DIS3L2 2q37.1 / FAM124B 2q36.2DIS3L2 2q37.1 / SPHKAP 2q36.3
DIS3L2 2q37.1 / UBE2E3 2q31.3EIF4E2 2q37.1 / DIS3L2 2q37.1GIGYF2 2q37.1 / DIS3L2 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Perlman syndrome (renal hamartomas, nephroblastomatosis and fetal gigantism)


External links

Nomenclature
HGNC (Hugo)DIS3L2   28648
LRG (Locus Reference Genomic)LRG_534
Cards
Entrez_Gene (NCBI)DIS3L2  129563  DIS3 like 3'-5' exoribonuclease 2
AliasesFAM6A; PRLMNS; hDIS3L2
GeneCards (Weizmann)DIS3L2
Ensembl hg19 (Hinxton)ENSG00000144535 [Gene_View]  chr2:232826293-233208678 [Contig_View]  DIS3L2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000144535 [Gene_View]  chr2:232826293-233208678 [Contig_View]  DIS3L2 [Vega]
ICGC DataPortalENSG00000144535
TCGA cBioPortalDIS3L2
AceView (NCBI)DIS3L2
Genatlas (Paris)DIS3L2
WikiGenes129563
SOURCE (Princeton)DIS3L2
Genetics Home Reference (NIH)DIS3L2
Genomic and cartography
GoldenPath hg19 (UCSC)DIS3L2  -     chr2:232826293-233208678 +  2q37.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DIS3L2  -     2q37.1   [Description]    (hg38-Dec_2013)
EnsemblDIS3L2 - 2q37.1 [CytoView hg19]  DIS3L2 - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIDIS3L2 [Mapview hg19]  DIS3L2 [Mapview hg38]
OMIM267000   614184   
Gene and transcription
Genbank (Entrez)AA781347 AF443854 AK090419 AK094293 AK295363
RefSeq transcript (Entrez)NM_001257281 NM_001257282 NM_152383
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_032572 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)DIS3L2
Cluster EST : UnigeneHs.732236 [ NCBI ]
CGAP (NCI)Hs.732236
Alternative Splicing GalleryENSG00000144535
Gene ExpressionDIS3L2 [ NCBI-GEO ]   DIS3L2 [ EBI - ARRAY_EXPRESS ]   DIS3L2 [ SEEK ]   DIS3L2 [ MEM ]
Gene Expression Viewer (FireBrowse)DIS3L2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)129563
GTEX Portal (Tissue expression)DIS3L2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYB7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYB7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYB7
Splice isoforms : SwissVarQ8IYB7
PhosPhoSitePlusQ8IYB7
Domaine pattern : Prosite (Expaxy)RIBONUCLEASE_II (PS01175)   
Domains : Interpro (EBI)DIS3L2    NA-bd_OB-fold    RNase_II/R_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DIS3L2
DMDM Disease mutations129563
Blocks (Seattle)DIS3L2
SuperfamilyQ8IYB7
Human Protein AtlasENSG00000144535
Peptide AtlasQ8IYB7
HPRD14619
IPIIPI00880048   IPI00217752   IPI00167753   IPI00385160   IPI00465384   IPI01014764   IPI00783908   IPI00917716   IPI00917763   IPI00917916   IPI00915877   IPI00915964   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYB7
IntAct (EBI)Q8IYB7
FunCoupENSG00000144535
BioGRIDDIS3L2
STRING (EMBL)DIS3L2
ZODIACDIS3L2
Ontologies - Pathways
QuickGOQ8IYB7
Ontology : AmiGO3'-5'-exoribonuclease activity  nuclear exosome (RNase complex)  cytoplasmic exosome (RNase complex)  magnesium ion binding  nuclear-transcribed mRNA catabolic process, exonucleolytic  cytoplasmic mRNA processing body  ribonuclease activity  protein binding  cytoplasm  polysome  rRNA processing  mitotic nuclear division  poly(U) RNA binding  negative regulation of cell proliferation  miRNA catabolic process  miRNA catabolic process  rRNA catabolic process  stem cell population maintenance  nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'  cell division  mitotic sister chromatid separation  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, exonucleolytic  RNA phosphodiester bond hydrolysis, exonucleolytic  polyuridylation-dependent mRNA catabolic process  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  nuclear exosome (RNase complex)  cytoplasmic exosome (RNase complex)  magnesium ion binding  nuclear-transcribed mRNA catabolic process, exonucleolytic  cytoplasmic mRNA processing body  ribonuclease activity  protein binding  cytoplasm  polysome  rRNA processing  mitotic nuclear division  poly(U) RNA binding  negative regulation of cell proliferation  miRNA catabolic process  miRNA catabolic process  rRNA catabolic process  stem cell population maintenance  nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'  cell division  mitotic sister chromatid separation  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, exonucleolytic  RNA phosphodiester bond hydrolysis, exonucleolytic  polyuridylation-dependent mRNA catabolic process  
NDEx NetworkDIS3L2
Atlas of Cancer Signalling NetworkDIS3L2
Wikipedia pathwaysDIS3L2
Orthology - Evolution
OrthoDB129563
GeneTree (enSembl)ENSG00000144535
Phylogenetic Trees/Animal Genes : TreeFamDIS3L2
HOVERGENQ8IYB7
HOGENOMQ8IYB7
Homologs : HomoloGeneDIS3L2
Homology/Alignments : Family Browser (UCSC)DIS3L2
Gene fusions - Rearrangements
Fusion : MitelmanDIS3L2/FAM124B [2q37.1/2q36.2]  
Fusion : MitelmanDIS3L2/SPHKAP [2q37.1/2q36.3]  [t(2;2)(q36;q37)]  
Fusion : MitelmanDIS3L2/UBE2E3 [2q37.1/2q31.3]  [t(2;2)(q31;q37)]  
Fusion : MitelmanEIF4E2/DIS3L2 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion : MitelmanGIGYF2/DIS3L2 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion: TCGADIS3L2 2q37.1 FAM124B 2q36.2 LUSC
Fusion: TCGADIS3L2 2q37.1 SPHKAP 2q36.3 BRCA
Fusion: TCGADIS3L2 2q37.1 UBE2E3 2q31.3 BRCA
Fusion: TCGAEIF4E2 2q37.1 DIS3L2 2q37.1 BRCA
Fusion: TCGAGIGYF2 2q37.1 DIS3L2 2q37.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDIS3L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DIS3L2
dbVarDIS3L2
ClinVarDIS3L2
1000_GenomesDIS3L2 
Exome Variant ServerDIS3L2
ExAC (Exome Aggregation Consortium)DIS3L2 (select the gene name)
Genetic variants : HAPMAP129563
Genomic Variants (DGV)DIS3L2 [DGVbeta]
DECIPHER (Syndromes)2:232826293-233208678  ENSG00000144535
CONAN: Copy Number AnalysisDIS3L2 
Mutations
ICGC Data PortalDIS3L2 
TCGA Data PortalDIS3L2 
Broad Tumor PortalDIS3L2
OASIS PortalDIS3L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDIS3L2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDIS3L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch DIS3L2
DgiDB (Drug Gene Interaction Database)DIS3L2
DoCM (Curated mutations)DIS3L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DIS3L2 (select a term)
intoGenDIS3L2
Cancer3DDIS3L2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM267000    614184   
Orphanet852    3474   
MedgenDIS3L2
Genetic Testing Registry DIS3L2
NextProtQ8IYB7 [Medical]
TSGene129563
GENETestsDIS3L2
Huge Navigator DIS3L2 [HugePedia]
snp3D : Map Gene to Disease129563
BioCentury BCIQDIS3L2
ClinGenDIS3L2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD129563
Chemical/Pharm GKB GenePA162383714
Clinical trialDIS3L2
Miscellaneous
canSAR (ICR)DIS3L2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDIS3L2
EVEXDIS3L2
GoPubMedDIS3L2
iHOPDIS3L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:58:55 CEST 2017

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