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DKK2 (dickkopf WNT signaling pathway inhibitor 2)

Identity

Alias_namesdickkopf (Xenopus laevis) homolog 2
dickkopf 2 homolog (Xenopus laevis)
Other aliasDKK-2
HGNC (Hugo) DKK2
LocusID (NCBI) 27123
Atlas_Id 46087
Location 4q25  [Link to chromosome band 4q25]
Location_base_pair Starts at 107842959 and ends at 107957453 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ZBTB7A (19p13.3) / DKK2 (4q25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DKK2   2892
Cards
Entrez_Gene (NCBI)DKK2  27123  dickkopf WNT signaling pathway inhibitor 2
AliasesDKK-2
GeneCards (Weizmann)DKK2
Ensembl hg19 (Hinxton)ENSG00000155011 [Gene_View]  chr4:107842959-107957453 [Contig_View]  DKK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000155011 [Gene_View]  chr4:107842959-107957453 [Contig_View]  DKK2 [Vega]
ICGC DataPortalENSG00000155011
TCGA cBioPortalDKK2
AceView (NCBI)DKK2
Genatlas (Paris)DKK2
WikiGenes27123
SOURCE (Princeton)DKK2
Genetics Home Reference (NIH)DKK2
Genomic and cartography
GoldenPath hg19 (UCSC)DKK2  -     chr4:107842959-107957453 -  4q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DKK2  -     4q25   [Description]    (hg38-Dec_2013)
EnsemblDKK2 - 4q25 [CytoView hg19]  DKK2 - 4q25 [CytoView hg38]
Mapping of homologs : NCBIDKK2 [Mapview hg19]  DKK2 [Mapview hg38]
OMIM605415   
Gene and transcription
Genbank (Entrez)AB033208 AB033941 AF177395 AK309466 AK312695
RefSeq transcript (Entrez)NM_014421
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)DKK2
Cluster EST : UnigeneHs.211869 [ NCBI ]
CGAP (NCI)Hs.211869
Alternative Splicing GalleryENSG00000155011
Gene ExpressionDKK2 [ NCBI-GEO ]   DKK2 [ EBI - ARRAY_EXPRESS ]   DKK2 [ SEEK ]   DKK2 [ MEM ]
Gene Expression Viewer (FireBrowse)DKK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27123
GTEX Portal (Tissue expression)DKK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBU2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBU2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBU2
Splice isoforms : SwissVarQ9UBU2
PhosPhoSitePlusQ9UBU2
Domains : Interpro (EBI)Dickkopf_N   
Domain families : Pfam (Sanger)Dickkopf_N (PF04706)   
Domain families : Pfam (NCBI)pfam04706   
Conserved Domain (NCBI)DKK2
DMDM Disease mutations27123
Blocks (Seattle)DKK2
SuperfamilyQ9UBU2
Human Protein AtlasENSG00000155011
Peptide AtlasQ9UBU2
HPRD05658
IPIIPI00002779   IPI00385984   IPI00966361   IPI00966205   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBU2
IntAct (EBI)Q9UBU2
FunCoupENSG00000155011
BioGRIDDKK2
STRING (EMBL)DKK2
ZODIACDKK2
Ontologies - Pathways
QuickGOQ9UBU2
Ontology : AmiGOextracellular space  multicellular organism development  Wnt signaling pathway  co-receptor binding  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIextracellular space  multicellular organism development  Wnt signaling pathway  co-receptor binding  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  
Pathways : BIOCARTAWnt/LRP6 Signalling [Genes]   
Pathways : KEGGWnt signaling pathway   
NDEx NetworkDKK2
Atlas of Cancer Signalling NetworkDKK2
Wikipedia pathwaysDKK2
Orthology - Evolution
OrthoDB27123
GeneTree (enSembl)ENSG00000155011
Phylogenetic Trees/Animal Genes : TreeFamDKK2
HOVERGENQ9UBU2
HOGENOMQ9UBU2
Homologs : HomoloGeneDKK2
Homology/Alignments : Family Browser (UCSC)DKK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDKK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DKK2
dbVarDKK2
ClinVarDKK2
1000_GenomesDKK2 
Exome Variant ServerDKK2
ExAC (Exome Aggregation Consortium)DKK2 (select the gene name)
Genetic variants : HAPMAP27123
Genomic Variants (DGV)DKK2 [DGVbeta]
DECIPHER (Syndromes)4:107842959-107957453  ENSG00000155011
CONAN: Copy Number AnalysisDKK2 
Mutations
ICGC Data PortalDKK2 
TCGA Data PortalDKK2 
Broad Tumor PortalDKK2
OASIS PortalDKK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDKK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDKK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DKK2
DgiDB (Drug Gene Interaction Database)DKK2
DoCM (Curated mutations)DKK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DKK2 (select a term)
intoGenDKK2
Cancer3DDKK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605415   
Orphanet
MedgenDKK2
Genetic Testing Registry DKK2
NextProtQ9UBU2 [Medical]
TSGene27123
GENETestsDKK2
Huge Navigator DKK2 [HugePedia]
snp3D : Map Gene to Disease27123
BioCentury BCIQDKK2
ClinGenDKK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27123
Chemical/Pharm GKB GenePA27346
Clinical trialDKK2
Miscellaneous
canSAR (ICR)DKK2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDKK2
EVEXDKK2
GoPubMedDKK2
iHOPDKK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:03:21 CET 2017

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