DKK2 (dickkopf WNT signaling pathway inhibitor 2)

2007-02-01  

Identity

HGNC
LOCATION
4q25
LOCUSID
ALIAS
DKK-2
FUSION GENES

Other Information

Locus ID:

NCBI: 27123
MIM: 605415
HGNC: 2892
Ensembl: ENSG00000155011

Variants:

dbSNP: 27123
ClinVar: 27123
TCGA: ENSG00000155011
COSMIC: DKK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155011ENST00000285311Q9UBU2
ENSG00000155011ENST00000510463D6RCC2
ENSG00000155011ENST00000513208D6RGF1

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingREACTOMER-HSA-5339717
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsREACTOMER-HSA-3772470

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
121677042002Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.59
165680852006Expression of Dickkopf genes is strongly reduced in malignant melanoma.49
197553932009Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways.34
215405522011The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.32
239999782014MicroRNA-21 promotes oral cancer invasion via the Wnt/β-catenin pathway by targeting DKK2.32
184616552008Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer.29
232042342013DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma.26
185247782008Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.23
195627782009Wnt antagonist gene polymorphisms and renal cancer.23

Citation

Dessen P

DKK2 (dickkopf WNT signaling pathway inhibitor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46087/dkk2