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DLAT (dihydrolipoamide S-acetyltransferase)

Identity

Other namesDLTA
PDC-E2
PDCE2
HGNC (Hugo) DLAT
LocusID (NCBI) 1737
Location 11q23.1
Location_base_pair Starts at 111895538 and ends at 111935002 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DLAT   2896
Cards
Entrez_Gene (NCBI)DLAT  1737  dihydrolipoamide S-acetyltransferase
GeneCards (Weizmann)DLAT
Ensembl (Hinxton)ENSG00000150768 [Gene_View]  chr11:111895538-111935002 [Contig_View]  DLAT [Vega]
ICGC DataPortalENSG00000150768
cBioPortalDLAT
AceView (NCBI)DLAT
Genatlas (Paris)DLAT
WikiGenes1737
SOURCE (Princeton)NM_001931
Genomic and cartography
GoldenPath (UCSC)DLAT  -  11q23.1   chr11:111895538-111935002 +  11q23.1   [Description]    (hg19-Feb_2009)
EnsemblDLAT - 11q23.1 [CytoView]
Mapping of homologs : NCBIDLAT [Mapview]
OMIM245348   608770   
Gene and transcription
Genbank (Entrez)AF317200 AK057299 AK223596 AK296274 AK297103
RefSeq transcript (Entrez)NM_001931
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_013342 NT_033899 NW_001838042 NW_004929381
Consensus coding sequences : CCDS (NCBI)DLAT
Cluster EST : UnigeneHs.335551 [ NCBI ]
CGAP (NCI)Hs.335551
Alternative Splicing : Fast-db (Paris)GSHG0005247
Alternative Splicing GalleryENSG00000150768
Gene ExpressionDLAT [ NCBI-GEO ]     DLAT [ SEEK ]   DLAT [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10515 (Uniprot)
NextProtP10515  [Medical]
With graphics : InterProP10515
Splice isoforms : SwissVarP10515 (Swissvar)
Catalytic activity : Enzyme2.3.1.12 [ Enzyme-Expasy ]   2.3.1.122.3.1.12 [ IntEnz-EBI ]   2.3.1.12 [ BRENDA ]   2.3.1.12 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS [organisation]   2-oxoacid_DH_actylTfrase [organisation]   Biotin_lipoyl [organisation]   CAT-like_dom [organisation]   E3-bd [organisation]   LAT1 [organisation]   Single_hybrid_motif [organisation]  
Related proteins : CluSTrP10515
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (NCBI)pfam00198    pfam00364    pfam02817   
DMDM Disease mutations1737
Blocks (Seattle)P10515
PDB (SRS)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (PDBSum)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (IMB)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (RSDB)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
Human Protein AtlasENSG00000150768 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP10515
HPRD10578
IPIIPI00021338   IPI00908638   IPI01010565   IPI00788836   IPI00975603   
Protein Interaction databases
DIP (DOE-UCLA)P10515
IntAct (EBI)P10515
FunCoupENSG00000150768
BioGRIDDLAT
InParanoidP10515
Interologous Interaction database P10515
IntegromeDBDLAT
STRING (EMBL)DLAT
Ontologies - Pathways
Ontology : AmiGOdihydrolipoyllysine-residue acetyltransferase activity  protein binding  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  pyruvate metabolic process  tricarboxylic acid cycle  regulation of acetyl-CoA biosynthetic process from pyruvate  cellular metabolic process  small molecule metabolic process  
Ontology : EGO-EBIdihydrolipoyllysine-residue acetyltransferase activity  protein binding  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  pyruvate metabolic process  tricarboxylic acid cycle  regulation of acetyl-CoA biosynthetic process from pyruvate  cellular metabolic process  small molecule metabolic process  
Pathways : KEGGGlycolysis / Gluconeogenesis    Citrate cycle (TCA cycle)    Pyruvate metabolism   
Protein Interaction DatabaseDLAT
Wikipedia pathwaysDLAT
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DLAT
snp3D : Map Gene to Disease1737
SNP (GeneSNP Utah)DLAT
SNP : HGBaseDLAT
Genetic variants : HAPMAPDLAT
Exome VariantDLAT
1000_GenomesDLAT 
ICGC programENSG00000150768 
Somatic Mutations in Cancer : COSMICDLAT 
CONAN: Copy Number AnalysisDLAT 
Mutations and Diseases : HGMDDLAT
Genomic VariantsDLAT  DLAT [DGVbeta]
dbVarDLAT
ClinVarDLAT
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM245348    608770   
MedgenDLAT
GENETestsDLAT
Disease Genetic AssociationDLAT
Huge Navigator DLAT [HugePedia]  DLAT [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneDLAT
Homology/Alignments : Family Browser (UCSC)DLAT
Phylogenetic Trees/Animal Genes : TreeFamDLAT
Chemical/Protein Interactions : CTD1737
Chemical/Pharm GKB GenePA27350
Clinical trialDLAT
Cancer Resource (Charite)ENSG00000150768
Other databases
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
CoreMineDLAT
iHOPDLAT
OncoSearchDLAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:51:28 CEST 2014

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