Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DLAT (dihydrolipoamide S-acetyltransferase)

Identity

Other namesDLTA
PDC-E2
PDCE2
HGNC (Hugo) DLAT
LocusID (NCBI) 1737
Location 11q23.1
Location_base_pair Starts at 111895538 and ends at 111935002 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DLAT   2896
Cards
Entrez_Gene (NCBI)DLAT  1737  dihydrolipoamide S-acetyltransferase
GeneCards (Weizmann)DLAT
Ensembl hg19 (Hinxton)ENSG00000150768 [Gene_View]  chr11:111895538-111935002 [Contig_View]  DLAT [Vega]
Ensembl hg38 (Hinxton)ENSG00000150768 [Gene_View]  chr11:111895538-111935002 [Contig_View]  DLAT [Vega]
ICGC DataPortalENSG00000150768
cBioPortalDLAT
AceView (NCBI)DLAT
Genatlas (Paris)DLAT
WikiGenes1737
SOURCE (Princeton)DLAT
Genomic and cartography
GoldenPath hg19 (UCSC)DLAT  -     chr11:111895538-111935002 +  11q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DLAT  -     11q23.1   [Description]    (hg38-Dec_2013)
EnsemblDLAT - 11q23.1 [CytoView hg19]  DLAT - 11q23.1 [CytoView hg38]
Mapping of homologs : NCBIDLAT [Mapview hg19]  DLAT [Mapview hg38]
OMIM245348   608770   
Gene and transcription
Genbank (Entrez)AF317200 AK057299 AK223596 AK296274 AK297103
RefSeq transcript (Entrez)NM_001931
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_013342 NT_033899 NW_001838042 NW_004929381
Consensus coding sequences : CCDS (NCBI)DLAT
Cluster EST : UnigeneHs.335551 [ NCBI ]
CGAP (NCI)Hs.335551
Alternative Splicing : Fast-db (Paris)GSHG0005247
Alternative Splicing GalleryENSG00000150768
Gene ExpressionDLAT [ NCBI-GEO ]     DLAT [ SEEK ]   DLAT [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10515 (Uniprot)
NextProtP10515  [Medical]
With graphics : InterProP10515
Splice isoforms : SwissVarP10515 (Swissvar)
Catalytic activity : Enzyme2.3.1.12 [ Enzyme-Expasy ]   2.3.1.122.3.1.12 [ IntEnz-EBI ]   2.3.1.12 [ BRENDA ]   2.3.1.12 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom    E3-bd    LAT1    Single_hybrid_motif   
Related proteins : CluSTrP10515
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (NCBI)pfam00198    pfam00364    pfam02817   
DMDM Disease mutations1737
Blocks (Seattle)P10515
PDB (SRS)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (PDBSum)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (IMB)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (RSDB)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
Human Protein AtlasENSG00000150768
Peptide AtlasP10515
HPRD10578
IPIIPI00021338   IPI00908638   IPI01010565   IPI00788836   IPI00975603   
Protein Interaction databases
DIP (DOE-UCLA)P10515
IntAct (EBI)P10515
FunCoupENSG00000150768
BioGRIDDLAT
IntegromeDBDLAT
STRING (EMBL)DLAT
Ontologies - Pathways
QuickGOP10515
Ontology : AmiGOdihydrolipoyllysine-residue acetyltransferase activity  protein binding  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  pyruvate metabolic process  tricarboxylic acid cycle  regulation of acetyl-CoA biosynthetic process from pyruvate  cellular metabolic process  small molecule metabolic process  
Ontology : EGO-EBIdihydrolipoyllysine-residue acetyltransferase activity  protein binding  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  pyruvate metabolic process  tricarboxylic acid cycle  regulation of acetyl-CoA biosynthetic process from pyruvate  cellular metabolic process  small molecule metabolic process  
Pathways : KEGGGlycolysis / Gluconeogenesis    Citrate cycle (TCA cycle)    Pyruvate metabolism   
Protein Interaction DatabaseDLAT
DoCM (Curated mutations)DLAT
Wikipedia pathwaysDLAT
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerDLAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLAT
dbVarDLAT
ClinVarDLAT
1000_GenomesDLAT 
Exome Variant ServerDLAT
SNP (GeneSNP Utah)DLAT
SNP : HGBaseDLAT
Genetic variants : HAPMAPDLAT
Genomic VariantsDLAT  DLAT [DGVbeta]
Mutations
ICGC Data PortalENSG00000150768 
Somatic Mutations in Cancer : COSMICDLAT 
CONAN: Copy Number AnalysisDLAT 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:111895538-111935002
Mutations and Diseases : HGMDDLAT
OMIM245348    608770   
MedgenDLAT
NextProtP10515 [Medical]
GENETestsDLAT
Disease Genetic AssociationDLAT
Huge Navigator DLAT [HugePedia]  DLAT [HugeCancerGEM]
snp3D : Map Gene to Disease1737
DGIdb (Drug Gene Interaction db)DLAT
General knowledge
Homologs : HomoloGeneDLAT
Homology/Alignments : Family Browser (UCSC)DLAT
Phylogenetic Trees/Animal Genes : TreeFamDLAT
Chemical/Protein Interactions : CTD1737
Chemical/Pharm GKB GenePA27350
Clinical trialDLAT
Cancer Resource (Charite)ENSG00000150768
Other databases
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
CoreMineDLAT
GoPubMedDLAT
iHOPDLAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:12:45 CET 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.