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DLAT (dihydrolipoamide S-acetyltransferase)

Identity

Other namesDLTA
PDC-E2
PDCE2
HGNC (Hugo) DLAT
LocusID (NCBI) 1737
Atlas_Id 47127
Location 11q23.1
Location_base_pair Starts at 111895538 and ends at 111935002 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C11orf57 (11q23.1) / DLAT (11q23.1)DLAT (11q23.1) / DLAT (11q23.1)DLAT (11q23.1) / SPTB (14q23.3)
MARK2 (11q13.1) / DLAT (11q23.1)SDHD (11q23.1) / DLAT (11q23.1)SPTB (14q23.3) / DLAT (11q23.1)
C11orf57 11q23.1 / DLAT 11q23.1MARK2 11q13.1 / DLAT 11q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DLAT   2896
Cards
Entrez_Gene (NCBI)DLAT  1737  dihydrolipoamide S-acetyltransferase
GeneCards (Weizmann)DLAT
Ensembl hg19 (Hinxton)ENSG00000150768 [Gene_View]  chr11:111895538-111935002 [Contig_View]  DLAT [Vega]
Ensembl hg38 (Hinxton)ENSG00000150768 [Gene_View]  chr11:111895538-111935002 [Contig_View]  DLAT [Vega]
ICGC DataPortalENSG00000150768
TCGA cBioPortalDLAT
AceView (NCBI)DLAT
Genatlas (Paris)DLAT
WikiGenes1737
SOURCE (Princeton)DLAT
Genomic and cartography
GoldenPath hg19 (UCSC)DLAT  -     chr11:111895538-111935002 +  11q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DLAT  -     11q23.1   [Description]    (hg38-Dec_2013)
EnsemblDLAT - 11q23.1 [CytoView hg19]  DLAT - 11q23.1 [CytoView hg38]
Mapping of homologs : NCBIDLAT [Mapview hg19]  DLAT [Mapview hg38]
OMIM245348   608770   
Gene and transcription
Genbank (Entrez)AF317200 AK057299 AK223596 AK296274 AK297103
RefSeq transcript (Entrez)NM_001931
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_013342 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)DLAT
Cluster EST : UnigeneHs.335551 [ NCBI ]
CGAP (NCI)Hs.335551
Alternative Splicing GalleryENSG00000150768
Gene ExpressionDLAT [ NCBI-GEO ]   DLAT [ EBI - ARRAY_EXPRESS ]   DLAT [ SEEK ]   DLAT [ MEM ]
Gene Expression Viewer (FireBrowse)DLAT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1737
GTEX Portal (Tissue expression)DLAT
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10515 (Uniprot)
NextProtP10515  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10515
Splice isoforms : SwissVarP10515 (Swissvar)
Catalytic activity : Enzyme2.3.1.12 [ Enzyme-Expasy ]   2.3.1.122.3.1.12 [ IntEnz-EBI ]   2.3.1.12 [ BRENDA ]   2.3.1.12 [ KEGG ]   
PhosPhoSitePlusP10515
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom    E3-bd    LAT1    Single_hybrid_motif   
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)    E3_binding (PF02817)   
Domain families : Pfam (NCBI)pfam00198    pfam00364    pfam02817   
DMDM Disease mutations1737
Blocks (Seattle)DLAT
PDB (SRS)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (PDBSum)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (IMB)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
PDB (RSDB)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
Structural Biology KnowledgeBase1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
SCOP (Structural Classification of Proteins)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
CATH (Classification of proteins structures)1FYC    1Y8N    1Y8O    1Y8P    2DNE    2PNR    2Q8I    3B8K    3CRK    3CRL   
SuperfamilyP10515
Human Protein AtlasENSG00000150768
Peptide AtlasP10515
HPRD10578
IPIIPI00021338   IPI00908638   IPI01010565   IPI00788836   IPI00975603   
Protein Interaction databases
DIP (DOE-UCLA)P10515
IntAct (EBI)P10515
FunCoupENSG00000150768
BioGRIDDLAT
STRING (EMBL)DLAT
ZODIACDLAT
Ontologies - Pathways
QuickGOP10515
Ontology : AmiGOdihydrolipoyllysine-residue acetyltransferase activity  dihydrolipoyllysine-residue acetyltransferase activity  protein binding  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  acetyl-CoA biosynthetic process from pyruvate  pyruvate metabolic process  tricarboxylic acid cycle  regulation of acetyl-CoA biosynthetic process from pyruvate  sleep  pyruvate dehydrogenase (NAD+) activity  pyruvate dehydrogenase (NAD+) activity  myelin sheath  pyruvate dehydrogenase complex  glyoxylate metabolic process  
Ontology : EGO-EBIdihydrolipoyllysine-residue acetyltransferase activity  dihydrolipoyllysine-residue acetyltransferase activity  protein binding  mitochondrion  mitochondrial matrix  mitochondrial pyruvate dehydrogenase complex  glucose metabolic process  acetyl-CoA biosynthetic process from pyruvate  pyruvate metabolic process  tricarboxylic acid cycle  regulation of acetyl-CoA biosynthetic process from pyruvate  sleep  pyruvate dehydrogenase (NAD+) activity  pyruvate dehydrogenase (NAD+) activity  myelin sheath  pyruvate dehydrogenase complex  glyoxylate metabolic process  
Pathways : KEGGGlycolysis / Gluconeogenesis    Citrate cycle (TCA cycle)    Pyruvate metabolism   
NDEx Network
Atlas of Cancer Signalling NetworkDLAT
Wikipedia pathwaysDLAT
Orthology - Evolution
OrthoDB1737
GeneTree (enSembl)ENSG00000150768
Phylogenetic Trees/Animal Genes : TreeFamDLAT
Homologs : HomoloGeneDLAT
Homology/Alignments : Family Browser (UCSC)DLAT
Gene fusions - Rearrangements
Fusion: TCGAC11orf57 11q23.1 DLAT 11q23.1 BRCA
Fusion: TCGAMARK2 11q13.1 DLAT 11q23.1 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerDLAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLAT
dbVarDLAT
ClinVarDLAT
1000_GenomesDLAT 
Exome Variant ServerDLAT
ExAC (Exome Aggregation Consortium)DLAT (select the gene name)
Genetic variants : HAPMAP1737
Genomic Variants (DGV)DLAT [DGVbeta]
Mutations
ICGC Data PortalDLAT 
TCGA Data PortalDLAT 
Broad Tumor PortalDLAT
OASIS PortalDLAT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLAT 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DLAT
DgiDB (Drug Gene Interaction Database)DLAT
DoCM (Curated mutations)DLAT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLAT (select a term)
intoGenDLAT
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:111895538-111935002  ENSG00000150768
CONAN: Copy Number AnalysisDLAT 
Mutations and Diseases : HGMDDLAT
OMIM245348    608770   
MedgenDLAT
Genetic Testing Registry DLAT
NextProtP10515 [Medical]
TSGene1737
GENETestsDLAT
Huge Navigator DLAT [HugePedia]
snp3D : Map Gene to Disease1737
BioCentury BCIQDLAT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1737
Chemical/Pharm GKB GenePA27350
Clinical trialDLAT
Miscellaneous
canSAR (ICR)DLAT (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLAT
EVEXDLAT
GoPubMedDLAT
iHOPDLAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:43:55 CEST 2016

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