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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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DLD (dihydrolipoamide dehydrogenase)

Identity

Other namesDLDD
DLDH
E3
GCSL
LAD
PHE3
HGNC (Hugo) DLD
LocusID (NCBI) 1738
Location 7q31.1
Location_base_pair Starts at 107531552 and ends at 107561643 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DLD   2898
Cards
Entrez_Gene (NCBI)DLD  1738  dihydrolipoamide dehydrogenase
GeneCards (Weizmann)DLD
Ensembl hg19 (Hinxton)ENSG00000091140 [Gene_View]  chr7:107531552-107561643 [Contig_View]  DLD [Vega]
Ensembl hg38 (Hinxton)ENSG00000091140 [Gene_View]  chr7:107531552-107561643 [Contig_View]  DLD [Vega]
ICGC DataPortalENSG00000091140
cBioPortalDLD
AceView (NCBI)DLD
Genatlas (Paris)DLD
WikiGenes1738
SOURCE (Princeton)DLD
Genomic and cartography
GoldenPath hg19 (UCSC)DLD  -     chr7:107531552-107561643 +  7q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DLD  -     7q31.1   [Description]    (hg38-Dec_2013)
EnsemblDLD - 7q31.1 [CytoView hg19]  DLD - 7q31.1 [CytoView hg38]
Mapping of homologs : NCBIDLD [Mapview hg19]  DLD [Mapview hg38]
OMIM238331   246900   
Gene and transcription
Genbank (Entrez)AB209703 AK225289 AK225301 AK294146 AK295080
RefSeq transcript (Entrez)NM_000108 NM_001289750 NM_001289751 NM_001289752
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_008045 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)DLD
Cluster EST : UnigeneHs.131711 [ NCBI ]
CGAP (NCI)Hs.131711
Alternative Splicing : Fast-db (Paris)GSHG0027645
Alternative Splicing GalleryENSG00000091140
Gene ExpressionDLD [ NCBI-GEO ]     DLD [ SEEK ]   DLD [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09622 (Uniprot)
NextProtP09622  [Medical]
With graphics : InterProP09622
Splice isoforms : SwissVarP09622 (Swissvar)
Catalytic activity : Enzyme1.8.1.4 [ Enzyme-Expasy ]   1.8.1.41.8.1.4 [ IntEnz-EBI ]   1.8.1.4 [ BRENDA ]   1.8.1.4 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PYRIDINE_REDOX_1 (PS00076)   
Domains : Interpro (EBI)FAD/NAD-linked_Rdtase_dimer    FAD_pyr_nucl-diS_OxRdtase    Lipoamide_DH    Pyr_nucl-diS_OxRdtase_dimer    Pyr_nucl-diS_OxRdtase_FAD/NAD    Pyr_OxRdtase_I_AS    Pyr_OxRdtase_NAD-bd_dom   
Related proteins : CluSTrP09622
Domain families : Pfam (Sanger)Pyr_redox (PF00070)    Pyr_redox_2 (PF07992)    Pyr_redox_dim (PF02852)   
Domain families : Pfam (NCBI)pfam00070    pfam07992    pfam02852   
DMDM Disease mutations1738
Blocks (Seattle)P09622
PDB (SRS)1ZMC    1ZMD    1ZY8    2F5Z    3RNM   
PDB (PDBSum)1ZMC    1ZMD    1ZY8    2F5Z    3RNM   
PDB (IMB)1ZMC    1ZMD    1ZY8    2F5Z    3RNM   
PDB (RSDB)1ZMC    1ZMD    1ZY8    2F5Z    3RNM   
Human Protein AtlasENSG00000091140
Peptide AtlasP09622
HPRD02006
IPIIPI00015911   IPI01011882   IPI01011421   IPI00926110   IPI00926319   IPI00926810   IPI00909143   IPI00927039   
Protein Interaction databases
DIP (DOE-UCLA)P09622
IntAct (EBI)P09622
FunCoupENSG00000091140
BioGRIDDLD
IntegromeDBDLD
STRING (EMBL)DLD
Ontologies - Pathways
QuickGOP09622
Ontology : AmiGOdihydrolipoyl dehydrogenase activity  nucleoplasm  mitochondrion  mitochondrial matrix  cilium  pyruvate metabolic process  tricarboxylic acid cycle  mitochondrial electron transport, NADH to ubiquinone  proteolysis  lysine catabolic process  gastrulation  branched-chain amino acid catabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  mercury (II) reductase activity  cellular nitrogen compound metabolic process  regulation of membrane potential  acrosomal matrix  cellular metabolic process  small molecule metabolic process  mercury ion binding  cell redox homeostasis  sperm capacitation  flavin adenine dinucleotide binding  NADP binding  detoxification of mercury ion  
Ontology : EGO-EBIdihydrolipoyl dehydrogenase activity  nucleoplasm  mitochondrion  mitochondrial matrix  cilium  pyruvate metabolic process  tricarboxylic acid cycle  mitochondrial electron transport, NADH to ubiquinone  proteolysis  lysine catabolic process  gastrulation  branched-chain amino acid catabolic process  regulation of acetyl-CoA biosynthetic process from pyruvate  mercury (II) reductase activity  cellular nitrogen compound metabolic process  regulation of membrane potential  acrosomal matrix  cellular metabolic process  small molecule metabolic process  mercury ion binding  cell redox homeostasis  sperm capacitation  flavin adenine dinucleotide binding  NADP binding  detoxification of mercury ion  
Pathways : KEGGGlycolysis / Gluconeogenesis    Citrate cycle (TCA cycle)    Glycine, serine and threonine metabolism    Valine, leucine and isoleucine degradation    Pyruvate metabolism   
Protein Interaction DatabaseDLD
DoCM (Curated mutations)DLD
Wikipedia pathwaysDLD
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerDLD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLD
dbVarDLD
ClinVarDLD
1000_GenomesDLD 
Exome Variant ServerDLD
SNP (GeneSNP Utah)DLD
SNP : HGBaseDLD
Genetic variants : HAPMAPDLD
Genomic Variants (DGV)DLD [DGVbeta]
Mutations
ICGC Data PortalENSG00000091140 
Somatic Mutations in Cancer : COSMICDLD 
CONAN: Copy Number AnalysisDLD 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:107531552-107561643
Mutations and Diseases : HGMDDLD
OMIM238331    246900   
MedgenDLD
NextProtP09622 [Medical]
GENETestsDLD
Disease Genetic AssociationDLD
Huge Navigator DLD [HugePedia]  DLD [HugeCancerGEM]
snp3D : Map Gene to Disease1738
DGIdb (Drug Gene Interaction db)DLD
General knowledge
Homologs : HomoloGeneDLD
Homology/Alignments : Family Browser (UCSC)DLD
Phylogenetic Trees/Animal Genes : TreeFamDLD
Chemical/Protein Interactions : CTD1738
Chemical/Pharm GKB GenePA27352
Clinical trialDLD
Cancer Resource (Charite)ENSG00000091140
Other databases
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
CoreMineDLD
GoPubMedDLD
iHOPDLD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 15:13:04 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.