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DLEC1 (deleted in lung and esophageal cancer 1)

Identity

Alias_symbol (synonym)DLC1
CFAP81
Other aliasDLC-1
F56
HGNC (Hugo) DLEC1
LocusID (NCBI) 9940
Atlas_Id 40329
Location 3p22.2  [Link to chromosome band 3p22]
Location_base_pair Starts at 38039205 and ends at 38122741 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DLEC1 (3p22.2) / EXOC6B (2p13.2)DLEC1 (3p22.2) / TENM4 (11q14.1)EPCAM (2p21) / DLEC1 (3p22.2)
TENM4 (11q14.1) / DLEC1 (3p22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)DLEC1   2899
Cards
Entrez_Gene (NCBI)DLEC1  9940  deleted in lung and esophageal cancer 1
AliasesCFAP81; DLC-1; DLC1; F56
GeneCards (Weizmann)DLEC1
Ensembl hg19 (Hinxton)ENSG00000008226 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008226 [Gene_View]  chr3:38039205-38122741 [Contig_View]  DLEC1 [Vega]
ICGC DataPortalENSG00000008226
TCGA cBioPortalDLEC1
AceView (NCBI)DLEC1
Genatlas (Paris)DLEC1
WikiGenes9940
SOURCE (Princeton)DLEC1
Genetics Home Reference (NIH)DLEC1
Genomic and cartography
GoldenPath hg38 (UCSC)DLEC1  -     chr3:38039205-38122741 +  3p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLEC1  -     3p22.2   [Description]    (hg19-Feb_2009)
EnsemblDLEC1 - 3p22.2 [CytoView hg19]  DLEC1 - 3p22.2 [CytoView hg38]
Mapping of homologs : NCBIDLEC1 [Mapview hg19]  DLEC1 [Mapview hg38]
OMIM133239   211980   604050   
Gene and transcription
Genbank (Entrez)AB020522 AB425198 AK302803 AL137282 AL137706
RefSeq transcript (Entrez)NM_001321153 NM_007335 NM_007336 NM_007337 NM_007338
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLEC1
Cluster EST : UnigeneHs.714499 [ NCBI ]
CGAP (NCI)Hs.714499
Alternative Splicing GalleryENSG00000008226
Gene ExpressionDLEC1 [ NCBI-GEO ]   DLEC1 [ EBI - ARRAY_EXPRESS ]   DLEC1 [ SEEK ]   DLEC1 [ MEM ]
Gene Expression Viewer (FireBrowse)DLEC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9940
GTEX Portal (Tissue expression)DLEC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y238   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y238  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y238
Splice isoforms : SwissVarQ9Y238
PhosPhoSitePlusQ9Y238
Domains : Interpro (EBI)DLEC1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DLEC1
DMDM Disease mutations9940
Blocks (Seattle)DLEC1
SuperfamilyQ9Y238
Human Protein AtlasENSG00000008226
Peptide AtlasQ9Y238
HPRD07234
IPIIPI00164104   IPI00377259   IPI00178066   IPI01011951   IPI00815704   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y238
IntAct (EBI)Q9Y238
FunCoupENSG00000008226
BioGRIDDLEC1
STRING (EMBL)DLEC1
ZODIACDLEC1
Ontologies - Pathways
QuickGOQ9Y238
Ontology : AmiGOmolecular_function  cytoplasm  cytosol  negative regulation of cell proliferation  
Ontology : EGO-EBImolecular_function  cytoplasm  cytosol  negative regulation of cell proliferation  
NDEx NetworkDLEC1
Atlas of Cancer Signalling NetworkDLEC1
Wikipedia pathwaysDLEC1
Orthology - Evolution
OrthoDB9940
GeneTree (enSembl)ENSG00000008226
Phylogenetic Trees/Animal Genes : TreeFamDLEC1
HOVERGENQ9Y238
HOGENOMQ9Y238
Homologs : HomoloGeneDLEC1
Homology/Alignments : Family Browser (UCSC)DLEC1
Gene fusions - Rearrangements
Fusion : MitelmanDLEC1/TENM4 [3p22.2/11q14.1]  
Fusion : MitelmanEPCAM/DLEC1 [2p21/3p22.2]  [t(2;3)(p21;p22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLEC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLEC1
dbVarDLEC1
ClinVarDLEC1
1000_GenomesDLEC1 
Exome Variant ServerDLEC1
ExAC (Exome Aggregation Consortium)DLEC1 (select the gene name)
Genetic variants : HAPMAP9940
Genomic Variants (DGV)DLEC1 [DGVbeta]
DECIPHERDLEC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLEC1 
Mutations
ICGC Data PortalDLEC1 
TCGA Data PortalDLEC1 
Broad Tumor PortalDLEC1
OASIS PortalDLEC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLEC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLEC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLEC1
DgiDB (Drug Gene Interaction Database)DLEC1
DoCM (Curated mutations)DLEC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLEC1 (select a term)
intoGenDLEC1
Cancer3DDLEC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM133239    211980    604050   
Orphanet
MedgenDLEC1
Genetic Testing Registry DLEC1
NextProtQ9Y238 [Medical]
TSGene9940
GENETestsDLEC1
Target ValidationDLEC1
Huge Navigator DLEC1 [HugePedia]
snp3D : Map Gene to Disease9940
BioCentury BCIQDLEC1
ClinGenDLEC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9940
Chemical/Pharm GKB GenePA27353
Clinical trialDLEC1
Miscellaneous
canSAR (ICR)DLEC1 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLEC1
EVEXDLEC1
GoPubMedDLEC1
iHOPDLEC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:36 CEST 2017

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