Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DLG2 (discs large MAGUK scaffold protein 2)

Identity

Alias_namesdiscs, large homolog 2, chapsyn-110 (Drosophila)
discs, large homolog 2 (Drosophila)
discs large homolog 2
Alias_symbol (synonym)PSD-93
PSD93
chapsyn-110
PPP1R58
Other alias
HGNC (Hugo) DLG2
LocusID (NCBI) 1740
Atlas_Id 62515
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 83455013 and ends at 85627270 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARRB1 (11q13.4) / DLG2 (11q14.1)CDH23 (10q22.1) / DLG2 (11q14.1)DLG2 (11q14.1) / DLG2 (11q14.1)
DLG2 (11q14.1) / PICALM (11q14.2)DLG2 (11q14.1) / RALGPS2 (1q25.2)INPP5A (10q26.3) / DLG2 (11q14.1)
LRP5 (11q13.2) / DLG2 (11q14.1)PLXNB2 (22q13.33) / DLG2 (11q14.1)PRMT5 (14q11.2) / DLG2 (11q14.1)
TCEAL2 (Xq22.1) / DLG2 (11q14.1)USP28 (11q23.2) / DLG2 (11q14.1)LRP5 DLG2
PLXNB2 DLG2INPP5A DLG2ARRB1 DLG2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DLG2   2901
Cards
Entrez_Gene (NCBI)DLG2  1740  discs large MAGUK scaffold protein 2
AliasesPPP1R58; PSD-93; PSD93; chapsyn-110
GeneCards (Weizmann)DLG2
Ensembl hg19 (Hinxton)ENSG00000150672 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150672 [Gene_View]  chr11:83455013-85627270 [Contig_View]  DLG2 [Vega]
ICGC DataPortalENSG00000150672
TCGA cBioPortalDLG2
AceView (NCBI)DLG2
Genatlas (Paris)DLG2
WikiGenes1740
SOURCE (Princeton)DLG2
Genetics Home Reference (NIH)DLG2
Genomic and cartography
GoldenPath hg38 (UCSC)DLG2  -     chr11:83455013-85627270 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLG2  -     11q14.1   [Description]    (hg19-Feb_2009)
EnsemblDLG2 - 11q14.1 [CytoView hg19]  DLG2 - 11q14.1 [CytoView hg38]
Mapping of homologs : NCBIDLG2 [Mapview hg19]  DLG2 [Mapview hg38]
OMIM603583   
Gene and transcription
Genbank (Entrez)AB209252 AK094585 AK125151 AK125152 AK126776
RefSeq transcript (Entrez)NM_001142699 NM_001142700 NM_001142702 NM_001206769 NM_001300983 NM_001351274 NM_001351275 NM_001351276 NM_001364
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLG2
Cluster EST : UnigeneHs.367656 [ NCBI ]
CGAP (NCI)Hs.367656
Alternative Splicing GalleryENSG00000150672
Gene ExpressionDLG2 [ NCBI-GEO ]   DLG2 [ EBI - ARRAY_EXPRESS ]   DLG2 [ SEEK ]   DLG2 [ MEM ]
Gene Expression Viewer (FireBrowse)DLG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1740
GTEX Portal (Tissue expression)DLG2
Human Protein AtlasENSG00000150672-DLG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15700   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15700  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15700
Splice isoforms : SwissVarQ15700
PhosPhoSitePlusQ15700
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_1 (PS00856)    GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    SH3 (PS50002)   
Domains : Interpro (EBI)DLG1    DLG1_PEST_dom    GK/Ca_channel_bsu    Guanylate_kin-like_dom    Guanylate_kinase_CS    P-loop_NTPase    PDZ    PDZ_assoc    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    MAGUK_N_PEST (PF10608)    PDZ (PF00595)    PDZ_assoc (PF10600)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00625    pfam10608    pfam00595    pfam10600    pfam07653   
Domain families : Smart (EMBL)GuKc (SM00072)  MAGUK_N_PEST (SM01277)  PDZ (SM00228)  SH3 (SM00326)  
Conserved Domain (NCBI)DLG2
DMDM Disease mutations1740
Blocks (Seattle)DLG2
PDB (SRS)2BYG    2HE2   
PDB (PDBSum)2BYG    2HE2   
PDB (IMB)2BYG    2HE2   
PDB (RSDB)2BYG    2HE2   
Structural Biology KnowledgeBase2BYG    2HE2   
SCOP (Structural Classification of Proteins)2BYG    2HE2   
CATH (Classification of proteins structures)2BYG    2HE2   
SuperfamilyQ15700
Human Protein Atlas [tissue]ENSG00000150672-DLG2 [tissue]
Peptide AtlasQ15700
HPRD04663
IPIIPI00444727   IPI00647950   IPI00444938   IPI00646771   IPI00395733   IPI01013631   IPI01013121   IPI00795962   IPI00985105   IPI00984468   IPI00796686   IPI00974073   IPI00973875   IPI00977261   IPI00978241   IPI00794641   IPI00977361   IPI01014073   IPI00984884   IPI01013600   IPI00982749   IPI00981664   
Protein Interaction databases
DIP (DOE-UCLA)Q15700
IntAct (EBI)Q15700
FunCoupENSG00000150672
BioGRIDDLG2
STRING (EMBL)DLG2
ZODIACDLG2
Ontologies - Pathways
QuickGOQ15700
Ontology : AmiGOguanylate kinase activity  protein binding  cytosol  plasma membrane  chemical synaptic transmission  nervous system development  voltage-gated potassium channel complex  ionotropic glutamate receptor complex  negative regulation of phosphatase activity  postsynaptic density  membrane  basolateral plasma membrane  sensory perception of pain  kinase binding  cell junction  ionotropic glutamate receptor binding  receptor clustering  juxtaparanode region of axon  establishment or maintenance of epithelial cell apical/basal polarity  postsynaptic membrane  GMP metabolic process  GDP metabolic process  receptor localization to synapse  
Ontology : EGO-EBIguanylate kinase activity  protein binding  cytosol  plasma membrane  chemical synaptic transmission  nervous system development  voltage-gated potassium channel complex  ionotropic glutamate receptor complex  negative regulation of phosphatase activity  postsynaptic density  membrane  basolateral plasma membrane  sensory perception of pain  kinase binding  cell junction  ionotropic glutamate receptor binding  receptor clustering  juxtaparanode region of axon  establishment or maintenance of epithelial cell apical/basal polarity  postsynaptic membrane  GMP metabolic process  GDP metabolic process  receptor localization to synapse  
Pathways : BIOCARTASynaptic Proteins at the Synaptic Junction [Genes]   
Pathways : KEGGHippo signaling pathway   
NDEx NetworkDLG2
Atlas of Cancer Signalling NetworkDLG2
Wikipedia pathwaysDLG2
Orthology - Evolution
OrthoDB1740
GeneTree (enSembl)ENSG00000150672
Phylogenetic Trees/Animal Genes : TreeFamDLG2
HOVERGENQ15700
HOGENOMQ15700
Homologs : HomoloGeneDLG2
Homology/Alignments : Family Browser (UCSC)DLG2
Gene fusions - Rearrangements
Fusion: TCGA_MDACCLRP5 DLG2
Fusion: TCGA_MDACCPLXNB2 DLG2
Fusion: TCGA_MDACCINPP5A DLG2
Fusion: TCGA_MDACCARRB1 DLG2
Tumor Fusion PortalDLG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLG2
dbVarDLG2
ClinVarDLG2
1000_GenomesDLG2 
Exome Variant ServerDLG2
ExAC (Exome Aggregation Consortium)ENSG00000150672
GNOMAD BrowserENSG00000150672
Genetic variants : HAPMAP1740
Genomic Variants (DGV)DLG2 [DGVbeta]
DECIPHERDLG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLG2 
Mutations
ICGC Data PortalDLG2 
TCGA Data PortalDLG2 
Broad Tumor PortalDLG2
OASIS PortalDLG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLG2
DgiDB (Drug Gene Interaction Database)DLG2
DoCM (Curated mutations)DLG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLG2 (select a term)
intoGenDLG2
Cancer3DDLG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603583   
Orphanet
DisGeNETDLG2
MedgenDLG2
Genetic Testing Registry DLG2
NextProtQ15700 [Medical]
TSGene1740
GENETestsDLG2
Target ValidationDLG2
Huge Navigator DLG2 [HugePedia]
snp3D : Map Gene to Disease1740
BioCentury BCIQDLG2
ClinGenDLG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1740
Chemical/Pharm GKB GenePA164741388
Clinical trialDLG2
Miscellaneous
canSAR (ICR)DLG2 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLG2
EVEXDLG2
GoPubMedDLG2
iHOPDLG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:23:18 CET 2017

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