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DLG2 (discs large MAGUK scaffold protein 2)

Identity

Alias (NCBI)PPP1R58
PSD-93
PSD93
chapsyn-110
HGNC (Hugo) DLG2
HGNC Alias symbPSD-93
PSD93
chapsyn-110
PPP1R58
HGNC Alias nameprotein phosphatase 1, regulatory subunit 58
HGNC Previous namediscs, large homolog 2, chapsyn-110 (Drosophila)
 discs, large homolog 2 (Drosophila)
 discs large homolog 2
LocusID (NCBI) 1740
Atlas_Id 62515
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 84017386 and ends at 84317337 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARRB1 (11q13.4) / DLG2 (11q14.1)CDH23 (10q22.1) / DLG2 (11q14.1)DLG2 (11q14.1) / DLG2 (11q14.1)
DLG2 (11q14.1) / PICALM (11q14.2)DLG2 (11q14.1) / RALGPS2 (1q25.2)INPP5A (10q26.3) / DLG2 (11q14.1)
LRP5 (11q13.2) / DLG2 (11q14.1)PLXNB2 (22q13.33) / DLG2 (11q14.1)PRMT5 (14q11.2) / DLG2 (11q14.1)
TCEAL2 (Xq22.1) / DLG2 (11q14.1)USP28 (11q23.2) / DLG2 (11q14.1)LRP5 DLG2
PLXNB2 DLG2INPP5A DLG2ARRB1 DLG2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DLG2   2901
Cards
Entrez_Gene (NCBI)DLG2    discs large MAGUK scaffold protein 2
AliasesPPP1R58; PSD-93; PSD93; chapsyn-110
GeneCards (Weizmann)DLG2
Ensembl hg19 (Hinxton)ENSG00000150672 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150672 [Gene_View]  ENSG00000150672 [Sequence]  chr11:84017386-84317337 [Contig_View]  DLG2 [Vega]
ICGC DataPortalENSG00000150672
TCGA cBioPortalDLG2
AceView (NCBI)DLG2
Genatlas (Paris)DLG2
SOURCE (Princeton)DLG2
Genetics Home Reference (NIH)DLG2
Genomic and cartography
GoldenPath hg38 (UCSC)DLG2  -     chr11:84017386-84317337 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLG2  -     11q14.1   [Description]    (hg19-Feb_2009)
GoldenPathDLG2 - 11q14.1 [CytoView hg19]  DLG2 - 11q14.1 [CytoView hg38]
ImmunoBaseENSG00000150672
Genome Data Viewer NCBIDLG2 [Mapview hg19]  
OMIM603583   
Gene and transcription
Genbank (Entrez)AB209252 AK094585 AK125151 AK125152 AK126776
RefSeq transcript (Entrez)NM_001142699 NM_001142700 NM_001142702 NM_001206769 NM_001300983 NM_001351274 NM_001351275 NM_001351276 NM_001364 NM_001377966 NM_001377967 NM_001377968 NM_001377970 NM_001377971 NM_001377972 NM_001377973 NM_001377974 NM_001377975 NM_001377976 NM_001377977 NM_001377978 NM_001377979 NM_001377980 NM_001377981 NM_001377982 NM_001377983
Consensus coding sequences : CCDS (NCBI)DLG2
Gene ExpressionDLG2 [ NCBI-GEO ]   DLG2 [ EBI - ARRAY_EXPRESS ]   DLG2 [ SEEK ]   DLG2 [ MEM ]
Gene Expression Viewer (FireBrowse)DLG2 [ Firebrowse - Broad ]
GenevisibleExpression of DLG2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1740
GTEX Portal (Tissue expression)DLG2
Human Protein AtlasENSG00000150672-DLG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15700   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15700  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15700
PhosPhoSitePlusQ15700
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_1 (PS00856)    GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    SH3 (PS50002)   
Domains : Interpro (EBI)DLG1-like    DLG1_PEST_dom    DLG2_SH3    GK/Ca_channel_bsu    Guanylate_kin-like_dom    Guanylate_kinase_CS    P-loop_NTPase    PDZ    PDZ_assoc    PDZ_sf    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    MAGUK_N_PEST (PF10608)    PDZ (PF00595)    PDZ_assoc (PF10600)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00625    pfam10608    pfam00595    pfam10600    pfam00018   
Domain families : Smart (EMBL)GuKc (SM00072)  MAGUK_N_PEST (SM01277)  PDZ (SM00228)  SH3 (SM00326)  
Conserved Domain (NCBI)DLG2
PDB (RSDB)2BYG    2HE2   
PDB Europe2BYG    2HE2   
PDB (PDBSum)2BYG    2HE2   
PDB (IMB)2BYG    2HE2   
Structural Biology KnowledgeBase2BYG    2HE2   
SCOP (Structural Classification of Proteins)2BYG    2HE2   
CATH (Classification of proteins structures)2BYG    2HE2   
SuperfamilyQ15700
AlphaFold pdb e-kbQ15700   
Human Protein Atlas [tissue]ENSG00000150672-DLG2 [tissue]
HPRD04663
Protein Interaction databases
DIP (DOE-UCLA)Q15700
IntAct (EBI)Q15700
BioGRIDDLG2
STRING (EMBL)DLG2
ZODIACDLG2
Ontologies - Pathways
QuickGOQ15700
Ontology : AmiGOMAPK cascade  guanylate kinase activity  protein binding  cytosol  plasma membrane  chemical synaptic transmission  embryo development  postsynaptic density  membrane  basolateral plasma membrane  kinase binding  cell junction  neuromuscular junction  cellular response to potassium ion  neuron projection  receptor clustering  perikaryon  juxtaparanode region of axon  establishment or maintenance of epithelial cell apical/basal polarity  GMP metabolic process  GDP metabolic process  receptor localization to synapse  cell-cell adhesion  postsynaptic density membrane  anterograde axonal protein transport  retrograde axonal protein transport  axon cytoplasm  regulation of NMDA receptor activity  
Ontology : EGO-EBIMAPK cascade  guanylate kinase activity  protein binding  cytosol  plasma membrane  chemical synaptic transmission  embryo development  postsynaptic density  membrane  basolateral plasma membrane  kinase binding  cell junction  neuromuscular junction  cellular response to potassium ion  neuron projection  receptor clustering  perikaryon  juxtaparanode region of axon  establishment or maintenance of epithelial cell apical/basal polarity  GMP metabolic process  GDP metabolic process  receptor localization to synapse  cell-cell adhesion  postsynaptic density membrane  anterograde axonal protein transport  retrograde axonal protein transport  axon cytoplasm  regulation of NMDA receptor activity  
Pathways : BIOCARTASynaptic Proteins at the Synaptic Junction [Genes]   
NDEx NetworkDLG2
Atlas of Cancer Signalling NetworkDLG2
Wikipedia pathwaysDLG2
Orthology - Evolution
OrthoDB1740
GeneTree (enSembl)ENSG00000150672
Phylogenetic Trees/Animal Genes : TreeFamDLG2
Homologs : HomoloGeneDLG2
Homology/Alignments : Family Browser (UCSC)DLG2
Gene fusions - Rearrangements
Fusion : QuiverDLG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLG2
dbVarDLG2
ClinVarDLG2
MonarchDLG2
1000_GenomesDLG2 
Exome Variant ServerDLG2
GNOMAD BrowserENSG00000150672
Varsome BrowserDLG2
ACMGDLG2 variants
VarityQ15700
Genomic Variants (DGV)DLG2 [DGVbeta]
DECIPHERDLG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLG2 
Mutations
ICGC Data PortalDLG2 
TCGA Data PortalDLG2 
Broad Tumor PortalDLG2
OASIS PortalDLG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLG2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDLG2
Mutations and Diseases : HGMDDLG2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDLG2
DgiDB (Drug Gene Interaction Database)DLG2
DoCM (Curated mutations)DLG2
CIViC (Clinical Interpretations of Variants in Cancer)DLG2
Cancer3DDLG2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603583   
Orphanet
DisGeNETDLG2
MedgenDLG2
Genetic Testing Registry DLG2
NextProtQ15700 [Medical]
GENETestsDLG2
Target ValidationDLG2
Huge Navigator DLG2 [HugePedia]
ClinGenDLG2
Clinical trials, drugs, therapy
MyCancerGenomeDLG2
Protein Interactions : CTDDLG2
Pharm GKB GenePA164741388
PharosQ15700
Clinical trialDLG2
Miscellaneous
canSAR (ICR)DLG2
HarmonizomeDLG2
DataMed IndexDLG2
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDLG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:47:59 CEST 2021

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