Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DLG3 (discs large MAGUK scaffold protein 3)

Identity

Alias_namesdiscs, large homolog 3 (neuroendocrine-dlg, Drosophila)
discs, large homolog 3 (Drosophila)
discs large homolog 3
Alias_symbol (synonym)NE-Dlg
SAP102
SAP-102
NEDLG
KIAA1232
MRX90
PPP1R82
Other aliasMRX
XLMR
HGNC (Hugo) DLG3
LocusID (NCBI) 1741
Atlas_Id 40334
Location Xq13.1  [Link to chromosome band Xq13]
Location_base_pair Starts at 70444855 and ends at 70505489 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APOC4 (19q13.32) / DLG3 (Xq13.1)DLG3 (Xq13.1) / SPTBN1 (2p16.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DLG3   2902
Cards
Entrez_Gene (NCBI)DLG3  1741  discs large MAGUK scaffold protein 3
AliasesMRX; MRX90; NEDLG; PPP1R82; 
SAP102; XLMR
GeneCards (Weizmann)DLG3
Ensembl hg19 (Hinxton)ENSG00000082458 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082458 [Gene_View]  ENSG00000082458 [Sequence]  chrX:70444855-70505489 [Contig_View]  DLG3 [Vega]
ICGC DataPortalENSG00000082458
TCGA cBioPortalDLG3
AceView (NCBI)DLG3
Genatlas (Paris)DLG3
WikiGenes1741
SOURCE (Princeton)DLG3
Genetics Home Reference (NIH)DLG3
Genomic and cartography
GoldenPath hg38 (UCSC)DLG3  -     chrX:70444855-70505489 +  Xq13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLG3  -     Xq13.1   [Description]    (hg19-Feb_2009)
EnsemblDLG3 - Xq13.1 [CytoView hg19]  DLG3 - Xq13.1 [CytoView hg38]
Mapping of homologs : NCBIDLG3 [Mapview hg19]  DLG3 [Mapview hg38]
OMIM300189   300850   
Gene and transcription
Genbank (Entrez)AB033058 AB209328 AK303377 AK304020 AK315041
RefSeq transcript (Entrez)NM_001166278 NM_020730 NM_021120
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLG3
Cluster EST : UnigeneHs.721586 [ NCBI ]
CGAP (NCI)Hs.721586
Alternative Splicing GalleryENSG00000082458
Gene ExpressionDLG3 [ NCBI-GEO ]   DLG3 [ EBI - ARRAY_EXPRESS ]   DLG3 [ SEEK ]   DLG3 [ MEM ]
Gene Expression Viewer (FireBrowse)DLG3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1741
GTEX Portal (Tissue expression)DLG3
Human Protein AtlasENSG00000082458-DLG3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92796   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92796  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92796
Splice isoforms : SwissVarQ92796
PhosPhoSitePlusQ92796
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_1 (PS00856)    GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    SH3 (PS50002)   
Domains : Interpro (EBI)DLG1-like    DLG1_PEST_dom    DLG3_SH3    GK/Ca_channel_bsu    Guanylate_kin-like_dom    Guanylate_kinase_CS    P-loop_NTPase    PDZ    PDZ_assoc    PDZ_sf    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    PDZ (PF00595)    PDZ_assoc (PF10600)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00625    pfam00595    pfam10600    pfam00018   
Domain families : Smart (EMBL)GuKc (SM00072)  MAGUK_N_PEST (SM01277)  PDZ (SM00228)  SH3 (SM00326)  
Conserved Domain (NCBI)DLG3
DMDM Disease mutations1741
Blocks (Seattle)DLG3
PDB (SRS)1UM7    2FE5    2I1N   
PDB (PDBSum)1UM7    2FE5    2I1N   
PDB (IMB)1UM7    2FE5    2I1N   
PDB (RSDB)1UM7    2FE5    2I1N   
Structural Biology KnowledgeBase1UM7    2FE5    2I1N   
SCOP (Structural Classification of Proteins)1UM7    2FE5    2I1N   
CATH (Classification of proteins structures)1UM7    2FE5    2I1N   
SuperfamilyQ92796
Human Protein Atlas [tissue]ENSG00000082458-DLG3 [tissue]
Peptide AtlasQ92796
HPRD02177
IPIIPI00023343   IPI00647338   IPI00952698   IPI00552701   
Protein Interaction databases
DIP (DOE-UCLA)Q92796
IntAct (EBI)Q92796
FunCoupENSG00000082458
BioGRIDDLG3
STRING (EMBL)DLG3
ZODIACDLG3
Ontologies - Pathways
QuickGOQ92796
Ontology : AmiGOMAPK cascade  establishment of planar polarity  Ras guanyl-nucleotide exchange factor activity  protein binding  extracellular space  cytosol  plasma membrane  bicellular tight junction  chemical synaptic transmission  protein C-terminus binding  negative regulation of cell proliferation  ionotropic glutamate receptor complex  negative regulation of phosphatase activity  basolateral plasma membrane  kinase binding  phosphatase binding  protein phosphatase binding  cell junction  PDZ domain binding  growth cone  neuromuscular junction  ubiquitin protein ligase binding  AMPA glutamate receptor complex  ionotropic glutamate receptor binding  neuron projection  neuronal cell body  receptor clustering  dendritic shaft  establishment or maintenance of epithelial cell apical/basal polarity  positive regulation of protein tyrosine kinase activity  receptor localization to synapse  cell-cell adhesion  postsynaptic density membrane  structural constituent of postsynaptic density  glutamatergic synapse  regulation of postsynaptic membrane neurotransmitter receptor levels  postsynaptic density, intracellular component  maintenance of postsynaptic density structure  
Ontology : EGO-EBIMAPK cascade  establishment of planar polarity  Ras guanyl-nucleotide exchange factor activity  protein binding  extracellular space  cytosol  plasma membrane  bicellular tight junction  chemical synaptic transmission  protein C-terminus binding  negative regulation of cell proliferation  ionotropic glutamate receptor complex  negative regulation of phosphatase activity  basolateral plasma membrane  kinase binding  phosphatase binding  protein phosphatase binding  cell junction  PDZ domain binding  growth cone  neuromuscular junction  ubiquitin protein ligase binding  AMPA glutamate receptor complex  ionotropic glutamate receptor binding  neuron projection  neuronal cell body  receptor clustering  dendritic shaft  establishment or maintenance of epithelial cell apical/basal polarity  positive regulation of protein tyrosine kinase activity  receptor localization to synapse  cell-cell adhesion  postsynaptic density membrane  structural constituent of postsynaptic density  glutamatergic synapse  regulation of postsynaptic membrane neurotransmitter receptor levels  postsynaptic density, intracellular component  maintenance of postsynaptic density structure  
Pathways : KEGGHippo signaling pathway   
NDEx NetworkDLG3
Atlas of Cancer Signalling NetworkDLG3
Wikipedia pathwaysDLG3
Orthology - Evolution
OrthoDB1741
GeneTree (enSembl)ENSG00000082458
Phylogenetic Trees/Animal Genes : TreeFamDLG3
HOGENOMQ92796
Homologs : HomoloGeneDLG3
Homology/Alignments : Family Browser (UCSC)DLG3
Gene fusions - Rearrangements
Fusion : QuiverDLG3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLG3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLG3
dbVarDLG3
ClinVarDLG3
1000_GenomesDLG3 
Exome Variant ServerDLG3
ExAC (Exome Aggregation Consortium)ENSG00000082458
GNOMAD BrowserENSG00000082458
Varsome BrowserDLG3
Genetic variants : HAPMAP1741
Genomic Variants (DGV)DLG3 [DGVbeta]
DECIPHERDLG3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLG3 
Mutations
ICGC Data PortalDLG3 
TCGA Data PortalDLG3 
Broad Tumor PortalDLG3
OASIS PortalDLG3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLG3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLG3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLG3
DgiDB (Drug Gene Interaction Database)DLG3
DoCM (Curated mutations)DLG3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLG3 (select a term)
intoGenDLG3
Cancer3DDLG3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300189    300850   
Orphanet3256   
DisGeNETDLG3
MedgenDLG3
Genetic Testing Registry DLG3
NextProtQ92796 [Medical]
TSGene1741
GENETestsDLG3
Target ValidationDLG3
Huge Navigator DLG3 [HugePedia]
snp3D : Map Gene to Disease1741
BioCentury BCIQDLG3
ClinGenDLG3 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1741
Chemical/Pharm GKB GenePA164741439
Clinical trialDLG3
Miscellaneous
canSAR (ICR)DLG3 (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLG3
EVEXDLG3
GoPubMedDLG3
iHOPDLG3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Dec 21 15:16:05 CET 2018
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