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DLGAP1 (DLG associated protein 1)

Identity

Alias (NCBI)DAP-1
DAP-1-ALPHA
DAP-1-BETA
DAP1
DLGAP1A
DLGAP1B
GKAP
SAPAP1
HGNC (Hugo) DLGAP1
HGNC Alias symbGKAP
SAPAP1
DAP-1
HGNC Previous namediscs, large (Drosophila) homolog-associated protein 1
 discs large homolog associated protein 1
LocusID (NCBI) 9229
Atlas_Id 57896
Location 18p11.31  [Link to chromosome band 18p11]
Location_base_pair Starts at 3496032 and ends at 4455307 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTN4 (19q13.2) / DLGAP1 (18p11.31)CLK2 (1q22) / DLGAP1 (18p11.31)DLGAP1 (18p11.31) / ENOSF1 (18p11.32)
DLGAP1 (18p11.31) / GNL2 (1p34.3)DLGAP1 (18p11.31) / LGR4 (11p14.1)DLGAP1 (18p11.31) / RAB31 (18p11.22)
DLGAP1 (18p11.31) / TRAM2 (6p12.2)DLGAP1 (18p11.31) / UCKL1 (20q13.33)HIST1H4A (6p22.2) / DLGAP1 (18p11.31)
MAPKBP1 (15q15.1) / DLGAP1 (18p11.31)MTCL1 (18p11.22) / DLGAP1 (18p11.31)SGIP1 (1p31.3) / DLGAP1 (18p11.31)
ZNF451 (6p12.1) / DLGAP1 (18p11.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  DLGAP1/ENOSF1 (18p11)
DLGAP1/RAB31 (18p11)
MTCL1/DLGAP1 (18p11)

External links

Nomenclature
HGNC (Hugo)DLGAP1   2905
Cards
Entrez_Gene (NCBI)DLGAP1    DLG associated protein 1
AliasesDAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1; 
DLGAP1A; DLGAP1B; GKAP; SAPAP1
GeneCards (Weizmann)DLGAP1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  chr18:3496032-4455307 [Contig_View]  DLGAP1 [Vega]
TCGA cBioPortalDLGAP1
AceView (NCBI)DLGAP1
Genatlas (Paris)DLGAP1
SOURCE (Princeton)DLGAP1
Genetics Home Reference (NIH)DLGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)DLGAP1  -     chr18:3496032-4455307 -  18p11.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLGAP1  -     18p11.31   [Description]    (hg19-Feb_2009)
GoldenPathDLGAP1 - 18p11.31 [CytoView hg19]  DLGAP1 - 18p11.31 [CytoView hg38]
genome Data Viewer NCBIDLGAP1 [Mapview hg19]  
OMIM605445   
Gene and transcription
Genbank (Entrez)AB000276 AB000277 AK095761 AK294717 AK294747
RefSeq transcript (Entrez)NM_001003809 NM_001242761 NM_001242762 NM_001242763 NM_001242764 NM_001242765 NM_001242766 NM_001308390 NM_004746
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLGAP1
Gene ExpressionDLGAP1 [ NCBI-GEO ]   DLGAP1 [ EBI - ARRAY_EXPRESS ]   DLGAP1 [ SEEK ]   DLGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)DLGAP1 [ Firebrowse - Broad ]
GenevisibleExpression of DLGAP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9229
GTEX Portal (Tissue expression)DLGAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14490   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14490  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14490
Splice isoforms : SwissVarO14490
PhosPhoSitePlusO14490
Domains : Interpro (EBI)DLGAP1    SAPAP   
Domain families : Pfam (Sanger)GKAP (PF03359)   
Domain families : Pfam (NCBI)pfam03359   
Conserved Domain (NCBI)DLGAP1
Blocks (Seattle)DLGAP1
PDB (RSDB)5YPO   
PDB Europe5YPO   
PDB (PDBSum)5YPO   
PDB (IMB)5YPO   
Structural Biology KnowledgeBase5YPO   
SCOP (Structural Classification of Proteins)5YPO   
CATH (Classification of proteins structures)5YPO   
SuperfamilyO14490
Peptide AtlasO14490
IPIIPI00021941   IPI00216228   IPI00216229   IPI00788990   IPI00790084   IPI00789415   
Protein Interaction databases
DIP (DOE-UCLA)O14490
IntAct (EBI)O14490
BioGRIDDLGAP1
STRING (EMBL)DLGAP1
ZODIACDLGAP1
Ontologies - Pathways
QuickGOO14490
Ontology : AmiGOprotein binding  cellular_component  plasma membrane  chemical synaptic transmission  postsynaptic density  protein-containing complex binding  
Ontology : EGO-EBIprotein binding  cellular_component  plasma membrane  chemical synaptic transmission  postsynaptic density  protein-containing complex binding  
Pathways : KEGGGlutamatergic synapse   
NDEx NetworkDLGAP1
Atlas of Cancer Signalling NetworkDLGAP1
Wikipedia pathwaysDLGAP1
Orthology - Evolution
OrthoDB9229
Phylogenetic Trees/Animal Genes : TreeFamDLGAP1
HOGENOMO14490
Homologs : HomoloGeneDLGAP1
Homology/Alignments : Family Browser (UCSC)DLGAP1
Gene fusions - Rearrangements
Fusion : QuiverDLGAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLGAP1 [hg38]
dbVarDLGAP1
ClinVarDLGAP1
MonarchDLGAP1
1000_GenomesDLGAP1 
Exome Variant ServerDLGAP1
Varsome BrowserDLGAP1
Genomic Variants (DGV)DLGAP1 [DGVbeta]
DECIPHERDLGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLGAP1 
Mutations
ICGC Data PortalDLGAP1 
TCGA Data PortalDLGAP1 
Broad Tumor PortalDLGAP1
OASIS PortalDLGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDLGAP1
Mutations and Diseases : HGMDDLGAP1
BioMutasearch DLGAP1
DgiDB (Drug Gene Interaction Database)DLGAP1
DoCM (Curated mutations)DLGAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLGAP1 (select a term)
intoGenDLGAP1
Cancer3DDLGAP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605445   
Orphanet
DisGeNETDLGAP1
MedgenDLGAP1
Genetic Testing Registry DLGAP1
NextProtO14490 [Medical]
GENETestsDLGAP1
Target ValidationDLGAP1
Huge Navigator DLGAP1 [HugePedia]
ClinGenDLGAP1
Clinical trials, drugs, therapy
MyCancerGenomeDLGAP1
Protein Interactions : CTD
Pharm GKB GenePA27361
PharosO14490
Clinical trialDLGAP1
Miscellaneous
canSAR (ICR)DLGAP1 (select the gene name)
HarmonizomeDLGAP1
DataMed IndexDLGAP1
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDLGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:13:03 CET 2021
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