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DLGAP4 (DLG associated protein 4)

Identity

Alias_namesdiscs, large (Drosophila) homolog-associated protein 4
discs large homolog associated protein 4
Alias_symbol (synonym)DAP4
KIAA0964
SAPAP4
Other aliasDAP-4
DLP4
SAPAP-4
HGNC (Hugo) DLGAP4
LocusID (NCBI) 22839
Atlas_Id 54256
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 36461415 and ends at 36528637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACOX3 (4p16.1) / DLGAP4 (20q11.23)ADNP (20q13.13) / DLGAP4 (20q11.23)DLGAP4 (20q11.23) / ADNP (20q13.13)
DLGAP4 (20q11.23) / BPI (20q11.23)DLGAP4 (20q11.23) / DLGAP4 (20q11.23)DLGAP4 (20q11.23) / SPSB3 (16p13.3)
DLGAP4 (20q11.23) / TUBD1 (17q23.1)DLGAP4 (20q11.23) / ZNF668 (16p11.2)HMCES (3q21.3) / DLGAP4 (20q11.23)
OSBPL2 (20q13.33) / DLGAP4 (20q11.23)POLR2J (7q22.1) / DLGAP4 (20q11.23)RAB3GAP2 (1q41) / DLGAP4 (20q11.23)
TGIF2 (20q11.23) / DLGAP4 (20q11.23)DLGAP4 20q11.23 / BPI 20q11.23DLGAP4 20q11.23 / TUBD1 17q23.1
OSBPL2 20q13.33 / DLGAP4 20q11.23TGIF2 20q11.23 / DLGAP4 20q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)DLGAP4   24476
Cards
Entrez_Gene (NCBI)DLGAP4  22839  DLG associated protein 4
AliasesDAP-4; DAP4; DLP4; SAPAP-4; 
SAPAP4
GeneCards (Weizmann)DLGAP4
Ensembl hg19 (Hinxton)ENSG00000080845 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080845 [Gene_View]  chr20:36461415-36528637 [Contig_View]  DLGAP4 [Vega]
ICGC DataPortalENSG00000080845
TCGA cBioPortalDLGAP4
AceView (NCBI)DLGAP4
Genatlas (Paris)DLGAP4
WikiGenes22839
SOURCE (Princeton)DLGAP4
Genetics Home Reference (NIH)DLGAP4
Genomic and cartography
GoldenPath hg38 (UCSC)DLGAP4  -     chr20:36461415-36528637 +  20q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLGAP4  -     20q11.23   [Description]    (hg19-Feb_2009)
EnsemblDLGAP4 - 20q11.23 [CytoView hg19]  DLGAP4 - 20q11.23 [CytoView hg38]
Mapping of homologs : NCBIDLGAP4 [Mapview hg19]  DLGAP4 [Mapview hg38]
OMIM616191   
Gene and transcription
Genbank (Entrez)AB023181 AF088030 AI984397 AK001681 AK024674
RefSeq transcript (Entrez)NM_001042486 NM_014902 NM_183006
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLGAP4
Cluster EST : UnigeneHs.249600 [ NCBI ]
CGAP (NCI)Hs.249600
Alternative Splicing GalleryENSG00000080845
Gene ExpressionDLGAP4 [ NCBI-GEO ]   DLGAP4 [ EBI - ARRAY_EXPRESS ]   DLGAP4 [ SEEK ]   DLGAP4 [ MEM ]
Gene Expression Viewer (FireBrowse)DLGAP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22839
GTEX Portal (Tissue expression)DLGAP4
Human Protein AtlasENSG00000080845-DLGAP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2H0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2H0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2H0
Splice isoforms : SwissVarQ9Y2H0
PhosPhoSitePlusQ9Y2H0
Domains : Interpro (EBI)DLGAP4    SAPAP   
Domain families : Pfam (Sanger)GKAP (PF03359)   
Domain families : Pfam (NCBI)pfam03359   
Conserved Domain (NCBI)DLGAP4
DMDM Disease mutations22839
Blocks (Seattle)DLGAP4
SuperfamilyQ9Y2H0
Human Protein Atlas [tissue]ENSG00000080845-DLGAP4 [tissue]
Peptide AtlasQ9Y2H0
HPRD16826
IPIIPI00007138   IPI00220581   IPI00411461   IPI00654770   IPI00946931   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2H0
IntAct (EBI)Q9Y2H0
FunCoupENSG00000080845
BioGRIDDLGAP4
STRING (EMBL)DLGAP4
ZODIACDLGAP4
Ontologies - Pathways
QuickGOQ9Y2H0
Ontology : AmiGOprotein binding  plasma membrane  signaling  synapse  
Ontology : EGO-EBIprotein binding  plasma membrane  signaling  synapse  
NDEx NetworkDLGAP4
Atlas of Cancer Signalling NetworkDLGAP4
Wikipedia pathwaysDLGAP4
Orthology - Evolution
OrthoDB22839
GeneTree (enSembl)ENSG00000080845
Phylogenetic Trees/Animal Genes : TreeFamDLGAP4
HOVERGENQ9Y2H0
HOGENOMQ9Y2H0
Homologs : HomoloGeneDLGAP4
Homology/Alignments : Family Browser (UCSC)DLGAP4
Gene fusions - Rearrangements
Fusion : MitelmanADNP/DLGAP4 [20q13.13/20q11.23]  [t(20;20)(q11;q13)]  
Fusion : MitelmanDLGAP4/ADNP [20q11.23/20q13.13]  [t(20;20)(q11;q13)]  
Fusion : MitelmanDLGAP4/BPI [20q11.23/20q11.23]  [t(20;20)(q11;q11)]  
Fusion : MitelmanDLGAP4/TUBD1 [20q11.23/17q23.1]  [t(17;20)(q23;q11)]  
Fusion : MitelmanOSBPL2/DLGAP4 [20q13.33/20q11.23]  [t(20;20)(q11;q13)]  
Fusion : MitelmanTGIF2/DLGAP4 [20q11.23/20q11.23]  [t(20;20)(q11;q11)]  
Fusion: TCGA_MDACCDLGAP4 20q11.23 BPI 20q11.23 LUAD
Fusion: TCGA_MDACCDLGAP4 20q11.23 TUBD1 17q23.1 BRCA
Fusion: TCGA_MDACCOSBPL2 20q13.33 DLGAP4 20q11.23 LUAD
Fusion: TCGA_MDACCTGIF2 20q11.23 DLGAP4 20q11.23 BRCA
Tumor Fusion PortalDLGAP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLGAP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLGAP4
dbVarDLGAP4
ClinVarDLGAP4
1000_GenomesDLGAP4 
Exome Variant ServerDLGAP4
ExAC (Exome Aggregation Consortium)ENSG00000080845
GNOMAD BrowserENSG00000080845
Genetic variants : HAPMAP22839
Genomic Variants (DGV)DLGAP4 [DGVbeta]
DECIPHERDLGAP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLGAP4 
Mutations
ICGC Data PortalDLGAP4 
TCGA Data PortalDLGAP4 
Broad Tumor PortalDLGAP4
OASIS PortalDLGAP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLGAP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLGAP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLGAP4
DgiDB (Drug Gene Interaction Database)DLGAP4
DoCM (Curated mutations)DLGAP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLGAP4 (select a term)
intoGenDLGAP4
Cancer3DDLGAP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616191   
Orphanet
DisGeNETDLGAP4
MedgenDLGAP4
Genetic Testing Registry DLGAP4
NextProtQ9Y2H0 [Medical]
TSGene22839
GENETestsDLGAP4
Target ValidationDLGAP4
Huge Navigator DLGAP4 [HugePedia]
snp3D : Map Gene to Disease22839
BioCentury BCIQDLGAP4
ClinGenDLGAP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22839
Chemical/Pharm GKB GenePA134891458
Clinical trialDLGAP4
Miscellaneous
canSAR (ICR)DLGAP4 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLGAP4
EVEXDLGAP4
GoPubMedDLGAP4
iHOPDLGAP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:10:42 CET 2017

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