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DLK1 (delta like non-canonical Notch ligand 1)

Identity

Alias_namesdelta-like homolog (Drosophila)
delta-like 1 homolog (Drosophila)
Alias_symbol (synonym)FA1
pG2
Pref-1
ZOG
Delta1
Other aliasDLK
DLK-1
PREF1
HGNC (Hugo) DLK1
LocusID (NCBI) 8788
Atlas_Id 46393
Location 14q32.2  [Link to chromosome band 14q32]
Location_base_pair Starts at 100726865 and ends at 100738224 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DLK1 (14q32.2) / DLK1 (14q32.2)DLK1 (14q32.2) / MED4 (13q14.2)DLK1 (14q32.2) / RPS11 (19q13.33)
PHPT1 (9q34.3) / DLK1 (14q32.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DLK1   2907
LRG (Locus Reference Genomic)LRG_1044
Cards
Entrez_Gene (NCBI)DLK1  8788  delta like non-canonical Notch ligand 1
AliasesDLK; DLK-1; Delta1; FA1; 
PREF1; Pref-1; ZOG; pG2
GeneCards (Weizmann)DLK1
Ensembl hg19 (Hinxton)ENSG00000185559 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185559 [Gene_View]  chr14:100726865-100738224 [Contig_View]  DLK1 [Vega]
ICGC DataPortalENSG00000185559
TCGA cBioPortalDLK1
AceView (NCBI)DLK1
Genatlas (Paris)DLK1
WikiGenes8788
SOURCE (Princeton)DLK1
Genetics Home Reference (NIH)DLK1
Genomic and cartography
GoldenPath hg38 (UCSC)DLK1  -     chr14:100726865-100738224 +  14q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLK1  -     14q32.2   [Description]    (hg19-Feb_2009)
EnsemblDLK1 - 14q32.2 [CytoView hg19]  DLK1 - 14q32.2 [CytoView hg38]
Mapping of homologs : NCBIDLK1 [Mapview hg19]  DLK1 [Mapview hg38]
OMIM176290   
Gene and transcription
Genbank (Entrez)AA668326 AK289384 AK297918 AK313258 BC007741
RefSeq transcript (Entrez)NM_001032997 NM_001317172 NM_003836
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLK1
Cluster EST : UnigeneHs.533717 [ NCBI ]
CGAP (NCI)Hs.533717
Alternative Splicing GalleryENSG00000185559
Gene ExpressionDLK1 [ NCBI-GEO ]   DLK1 [ EBI - ARRAY_EXPRESS ]   DLK1 [ SEEK ]   DLK1 [ MEM ]
Gene Expression Viewer (FireBrowse)DLK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8788
GTEX Portal (Tissue expression)DLK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP80370   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP80370  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP80370
Splice isoforms : SwissVarP80370
PhosPhoSitePlusP80370
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site   
Domain families : Pfam (Sanger)EGF (PF00008)   
Domain families : Pfam (NCBI)pfam00008   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)DLK1
DMDM Disease mutations8788
Blocks (Seattle)DLK1
SuperfamilyP80370
Human Protein AtlasENSG00000185559
Peptide AtlasP80370
HPRD01446
IPIIPI00160384   IPI00218210   IPI00873469   IPI01026351   IPI01026482   
Protein Interaction databases
DIP (DOE-UCLA)P80370
IntAct (EBI)P80370
FunCoupENSG00000185559
BioGRIDDLK1
STRING (EMBL)DLK1
ZODIACDLK1
Ontologies - Pathways
QuickGOP80370
Ontology : AmiGOmolecular_function  calcium ion binding  extracellular space  integral component of membrane  cell differentiation  negative regulation of Notch signaling pathway  
Ontology : EGO-EBImolecular_function  calcium ion binding  extracellular space  integral component of membrane  cell differentiation  negative regulation of Notch signaling pathway  
NDEx NetworkDLK1
Atlas of Cancer Signalling NetworkDLK1
Wikipedia pathwaysDLK1
Orthology - Evolution
OrthoDB8788
GeneTree (enSembl)ENSG00000185559
Phylogenetic Trees/Animal Genes : TreeFamDLK1
HOVERGENP80370
HOGENOMP80370
Homologs : HomoloGeneDLK1
Homology/Alignments : Family Browser (UCSC)DLK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLK1
dbVarDLK1
ClinVarDLK1
1000_GenomesDLK1 
Exome Variant ServerDLK1
ExAC (Exome Aggregation Consortium)DLK1 (select the gene name)
Genetic variants : HAPMAP8788
Genomic Variants (DGV)DLK1 [DGVbeta]
DECIPHERDLK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLK1 
Mutations
ICGC Data PortalDLK1 
TCGA Data PortalDLK1 
Broad Tumor PortalDLK1
OASIS PortalDLK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLK1
DgiDB (Drug Gene Interaction Database)DLK1
DoCM (Curated mutations)DLK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLK1 (select a term)
intoGenDLK1
Cancer3DDLK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176290   
Orphanet19758    19759    19761    19760    12808    12843   
MedgenDLK1
Genetic Testing Registry DLK1
NextProtP80370 [Medical]
TSGene8788
GENETestsDLK1
Target ValidationDLK1
Huge Navigator DLK1 [HugePedia]
snp3D : Map Gene to Disease8788
BioCentury BCIQDLK1
ClinGenDLK1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8788
Chemical/Pharm GKB GenePA27363
Clinical trialDLK1
Miscellaneous
canSAR (ICR)DLK1 (select the gene name)
Probes
Litterature
PubMed127 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLK1
EVEXDLK1
GoPubMedDLK1
iHOPDLK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:51:44 CEST 2017

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