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DLK2 (delta like non-canonical Notch ligand 2)

Identity

Alias_namesEGFL9
EGF-like-domain, multiple 9
delta-like 2 homolog (Drosophila)
Alias_symbol (synonym)MGC2487
Other aliasDLK-2
HGNC (Hugo) DLK2
LocusID (NCBI) 65989
Atlas_Id 62527
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 43450352 and ends at 43456632 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PTK7 (6p21.1) / DLK2 (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p21) PTK7/DLK2


External links

Nomenclature
HGNC (Hugo)DLK2   21113
Cards
Entrez_Gene (NCBI)DLK2  65989  delta like non-canonical Notch ligand 2
AliasesDLK-2; EGFL9
GeneCards (Weizmann)DLK2
Ensembl hg19 (Hinxton)ENSG00000171462 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171462 [Gene_View]  ENSG00000171462 [Sequence]  chr6:43450352-43456632 [Contig_View]  DLK2 [Vega]
ICGC DataPortalENSG00000171462
TCGA cBioPortalDLK2
AceView (NCBI)DLK2
Genatlas (Paris)DLK2
WikiGenes65989
SOURCE (Princeton)DLK2
Genetics Home Reference (NIH)DLK2
Genomic and cartography
GoldenPath hg38 (UCSC)DLK2  -     chr6:43450352-43456632 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLK2  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblDLK2 - 6p21.1 [CytoView hg19]  DLK2 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIDLK2 [Mapview hg19]  DLK2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK055380 AY358126 BC000230 BC006425 BC110320
RefSeq transcript (Entrez)NM_001286655 NM_001286656 NM_023932 NM_206539
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLK2
Cluster EST : UnigeneHs.337251 [ NCBI ]
CGAP (NCI)Hs.337251
Alternative Splicing GalleryENSG00000171462
Gene ExpressionDLK2 [ NCBI-GEO ]   DLK2 [ EBI - ARRAY_EXPRESS ]   DLK2 [ SEEK ]   DLK2 [ MEM ]
Gene Expression Viewer (FireBrowse)DLK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65989
GTEX Portal (Tissue expression)DLK2
Human Protein AtlasENSG00000171462-DLK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UY11   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UY11  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UY11
Splice isoforms : SwissVarQ6UY11
PhosPhoSitePlusQ6UY11
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS   
Domain families : Pfam (Sanger)EGF (PF00008)    hEGF (PF12661)   
Domain families : Pfam (NCBI)pfam00008    pfam12661   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)DLK2
DMDM Disease mutations65989
Blocks (Seattle)DLK2
SuperfamilyQ6UY11
Human Protein Atlas [tissue]ENSG00000171462-DLK2 [tissue]
Peptide AtlasQ6UY11
HPRD16855
IPIIPI00028381   IPI00470448   IPI00640948   IPI00647059   
Protein Interaction databases
DIP (DOE-UCLA)Q6UY11
IntAct (EBI)Q6UY11
FunCoupENSG00000171462
BioGRIDDLK2
STRING (EMBL)DLK2
ZODIACDLK2
Ontologies - Pathways
QuickGOQ6UY11
Ontology : AmiGOcalcium ion binding  integral component of membrane  protein homodimerization activity  regulation of fat cell differentiation  negative regulation of Notch signaling pathway  extracellular exosome  
Ontology : EGO-EBIcalcium ion binding  integral component of membrane  protein homodimerization activity  regulation of fat cell differentiation  negative regulation of Notch signaling pathway  extracellular exosome  
NDEx NetworkDLK2
Atlas of Cancer Signalling NetworkDLK2
Wikipedia pathwaysDLK2
Orthology - Evolution
OrthoDB65989
GeneTree (enSembl)ENSG00000171462
Phylogenetic Trees/Animal Genes : TreeFamDLK2
HOVERGENQ6UY11
HOGENOMQ6UY11
Homologs : HomoloGeneDLK2
Homology/Alignments : Family Browser (UCSC)DLK2
Gene fusions - Rearrangements
Fusion : QuiverDLK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLK2
dbVarDLK2
ClinVarDLK2
1000_GenomesDLK2 
Exome Variant ServerDLK2
ExAC (Exome Aggregation Consortium)ENSG00000171462
GNOMAD BrowserENSG00000171462
Varsome BrowserDLK2
Genetic variants : HAPMAP65989
Genomic Variants (DGV)DLK2 [DGVbeta]
DECIPHERDLK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLK2 
Mutations
ICGC Data PortalDLK2 
TCGA Data PortalDLK2 
Broad Tumor PortalDLK2
OASIS PortalDLK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLK2
DgiDB (Drug Gene Interaction Database)DLK2
DoCM (Curated mutations)DLK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLK2 (select a term)
intoGenDLK2
Cancer3DDLK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETDLK2
MedgenDLK2
Genetic Testing Registry DLK2
NextProtQ6UY11 [Medical]
TSGene65989
GENETestsDLK2
Target ValidationDLK2
Huge Navigator DLK2 [HugePedia]
snp3D : Map Gene to Disease65989
BioCentury BCIQDLK2
ClinGenDLK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65989
Chemical/Pharm GKB GenePA162383762
Clinical trialDLK2
Miscellaneous
canSAR (ICR)DLK2 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLK2
EVEXDLK2
GoPubMedDLK2
iHOPDLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:42:53 CEST 2018

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