Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DLL1 (delta like canonical Notch ligand 1)

Identity

Alias_namesdelta (Drosophila)-like 1
delta-like 1 (Drosophila)
Other aliasDELTA1
DL1
Delta
HGNC (Hugo) DLL1
LocusID (NCBI) 28514
Atlas_Id 45960
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 170282206 and ends at 170290609 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RTN1 (14q23.1) / DLL1 (6q27)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DLL1   2908
Cards
Entrez_Gene (NCBI)DLL1  28514  delta like canonical Notch ligand 1
AliasesDELTA1; DL1; Delta
GeneCards (Weizmann)DLL1
Ensembl hg19 (Hinxton)ENSG00000198719 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198719 [Gene_View]  ENSG00000198719 [Sequence]  chr6:170282206-170290609 [Contig_View]  DLL1 [Vega]
ICGC DataPortalENSG00000198719
TCGA cBioPortalDLL1
AceView (NCBI)DLL1
Genatlas (Paris)DLL1
WikiGenes28514
SOURCE (Princeton)DLL1
Genetics Home Reference (NIH)DLL1
Genomic and cartography
GoldenPath hg38 (UCSC)DLL1  -     chr6:170282206-170290609 -  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLL1  -     6q27   [Description]    (hg19-Feb_2009)
EnsemblDLL1 - 6q27 [CytoView hg19]  DLL1 - 6q27 [CytoView hg38]
Mapping of homologs : NCBIDLL1 [Mapview hg19]  DLL1 [Mapview hg38]
OMIM606582   
Gene and transcription
Genbank (Entrez)AF196571 AK311474 AK314234 AY358892 BC028096
RefSeq transcript (Entrez)NM_005618
RefSeq genomic (Entrez)NC_000006 NG_027940 NT_187553
Consensus coding sequences : CCDS (NCBI)DLL1
Cluster EST : UnigeneHs.379912 [ NCBI ]
CGAP (NCI)Hs.379912
Alternative Splicing GalleryENSG00000198719
Gene ExpressionDLL1 [ NCBI-GEO ]   DLL1 [ EBI - ARRAY_EXPRESS ]   DLL1 [ SEEK ]   DLL1 [ MEM ]
Gene Expression Viewer (FireBrowse)DLL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28514
GTEX Portal (Tissue expression)DLL1
Human Protein AtlasENSG00000198719-DLL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00548   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00548  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00548
Splice isoforms : SwissVarO00548
PhosPhoSitePlusO00548
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    DSL (PS51051)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)DSL    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_cys_sf    Notch_ligand_N   
Domain families : Pfam (Sanger)DSL (PF01414)    EGF (PF00008)    hEGF (PF12661)    MNNL (PF07657)   
Domain families : Pfam (NCBI)pfam01414    pfam00008    pfam12661    pfam07657   
Domain families : Smart (EMBL)DSL (SM00051)  EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)DLL1
DMDM Disease mutations28514
Blocks (Seattle)DLL1
PDB (SRS)4XBM   
PDB (PDBSum)4XBM   
PDB (IMB)4XBM   
PDB (RSDB)4XBM   
Structural Biology KnowledgeBase4XBM   
SCOP (Structural Classification of Proteins)4XBM   
CATH (Classification of proteins structures)4XBM   
SuperfamilyO00548
Human Protein Atlas [tissue]ENSG00000198719-DLL1 [tissue]
Peptide AtlasO00548
HPRD05957
IPIIPI00413521   IPI00913854   
Protein Interaction databases
DIP (DOE-UCLA)O00548
IntAct (EBI)O00548
FunCoupENSG00000198719
BioGRIDDLL1
STRING (EMBL)DLL1
ZODIACDLL1
Ontologies - Pathways
QuickGOO00548
Ontology : AmiGOcell fate determination  somitogenesis  somite specification  heart looping  marginal zone B cell differentiation  type B pancreatic cell development  Notch binding  calcium ion binding  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  adherens junction  Notch signaling pathway  Notch signaling pathway  Notch signaling pathway  determination of left/right symmetry  compartment pattern specification  regulation of blood pressure  positive regulation of cell proliferation  negative regulation of cell proliferation  proximal/distal pattern formation  astrocyte development  regulation of somitogenesis  apical plasma membrane  spinal cord development  cerebellar molecular layer formation  cerebellar Purkinje cell layer structural organization  hemopoiesis  cell differentiation  regulation of cell adhesion  negative regulation of epithelial cell differentiation  Tat protein binding  cytoplasmic vesicle  negative regulation of interleukin-10 production  negative regulation of glial cell apoptotic process  organ growth  regulation of growth  membrane raft  negative regulation of cell differentiation  negative regulation of epidermal cell differentiation  negative regulation of inner ear auditory receptor cell differentiation  negative regulation of myeloid cell differentiation  negative regulation of myoblast differentiation  negative regulation of neuron differentiation  positive regulation of Notch signaling pathway  positive regulation of endocytosis  positive regulation of transcription by RNA polymerase II  lateral inhibition  skeletal muscle tissue growth  regulation of skeletal muscle tissue growth  positive regulation of skeletal muscle tissue growth  neuron fate specification  inner ear development  regulation of neurogenesis  regulation of cell division  retina development in camera-type eye  retina morphogenesis in camera-type eye  Notch signaling pathway involved in arterial endothelial cell fate commitment  left/right axis specification  nephron development  proximal tubule development  loop of Henle development  clathrin-dependent endocytosis  energy homeostasis  endothelial tip cell fate specification  scaffold protein binding  neuronal stem cell population maintenance  neuronal stem cell population maintenance  skin epidermis development  regulation of vascular endothelial growth factor signaling pathway  positive regulation of sprouting angiogenesis  negative regulation of cardiac muscle cell differentiation  
Ontology : EGO-EBIcell fate determination  somitogenesis  somite specification  heart looping  marginal zone B cell differentiation  type B pancreatic cell development  Notch binding  calcium ion binding  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  adherens junction  Notch signaling pathway  Notch signaling pathway  Notch signaling pathway  determination of left/right symmetry  compartment pattern specification  regulation of blood pressure  positive regulation of cell proliferation  negative regulation of cell proliferation  proximal/distal pattern formation  astrocyte development  regulation of somitogenesis  apical plasma membrane  spinal cord development  cerebellar molecular layer formation  cerebellar Purkinje cell layer structural organization  hemopoiesis  cell differentiation  regulation of cell adhesion  negative regulation of epithelial cell differentiation  Tat protein binding  cytoplasmic vesicle  negative regulation of interleukin-10 production  negative regulation of glial cell apoptotic process  organ growth  regulation of growth  membrane raft  negative regulation of cell differentiation  negative regulation of epidermal cell differentiation  negative regulation of inner ear auditory receptor cell differentiation  negative regulation of myeloid cell differentiation  negative regulation of myoblast differentiation  negative regulation of neuron differentiation  positive regulation of Notch signaling pathway  positive regulation of endocytosis  positive regulation of transcription by RNA polymerase II  lateral inhibition  skeletal muscle tissue growth  regulation of skeletal muscle tissue growth  positive regulation of skeletal muscle tissue growth  neuron fate specification  inner ear development  regulation of neurogenesis  regulation of cell division  retina development in camera-type eye  retina morphogenesis in camera-type eye  Notch signaling pathway involved in arterial endothelial cell fate commitment  left/right axis specification  nephron development  proximal tubule development  loop of Henle development  clathrin-dependent endocytosis  energy homeostasis  endothelial tip cell fate specification  scaffold protein binding  neuronal stem cell population maintenance  neuronal stem cell population maintenance  skin epidermis development  regulation of vascular endothelial growth factor signaling pathway  positive regulation of sprouting angiogenesis  negative regulation of cardiac muscle cell differentiation  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkDLL1
Atlas of Cancer Signalling NetworkDLL1
Wikipedia pathwaysDLL1
Orthology - Evolution
OrthoDB28514
GeneTree (enSembl)ENSG00000198719
Phylogenetic Trees/Animal Genes : TreeFamDLL1
HOVERGENO00548
HOGENOMO00548
Homologs : HomoloGeneDLL1
Homology/Alignments : Family Browser (UCSC)DLL1
Gene fusions - Rearrangements
Fusion : QuiverDLL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLL1
dbVarDLL1
ClinVarDLL1
1000_GenomesDLL1 
Exome Variant ServerDLL1
ExAC (Exome Aggregation Consortium)ENSG00000198719
GNOMAD BrowserENSG00000198719
Varsome BrowserDLL1
Genetic variants : HAPMAP28514
Genomic Variants (DGV)DLL1 [DGVbeta]
DECIPHERDLL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLL1 
Mutations
ICGC Data PortalDLL1 
TCGA Data PortalDLL1 
Broad Tumor PortalDLL1
OASIS PortalDLL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLL1
DgiDB (Drug Gene Interaction Database)DLL1
DoCM (Curated mutations)DLL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLL1 (select a term)
intoGenDLL1
Cancer3DDLL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606582   
Orphanet20436    20435    18904    12486    12484    12485   
DisGeNETDLL1
MedgenDLL1
Genetic Testing Registry DLL1
NextProtO00548 [Medical]
TSGene28514
GENETestsDLL1
Target ValidationDLL1
Huge Navigator DLL1 [HugePedia]
snp3D : Map Gene to Disease28514
BioCentury BCIQDLL1
ClinGenDLL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD28514
Chemical/Pharm GKB GenePA27364
Clinical trialDLL1
Miscellaneous
canSAR (ICR)DLL1 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLL1
EVEXDLL1
GoPubMedDLL1
iHOPDLL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:02:39 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.