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DLL3 (delta like canonical Notch ligand 3)

Identity

Alias_namesdelta (Drosophila)-like 3
delta-like 3 (Drosophila)
Alias_symbol (synonym)SCDO1
Other alias
HGNC (Hugo) DLL3
LocusID (NCBI) 10683
Atlas_Id 47257
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39498917 and ends at 39508481 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TAOK3 (12q24.23) / DLL3 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DLL3   2909
Cards
Entrez_Gene (NCBI)DLL3  10683  delta like canonical Notch ligand 3
AliasesSCDO1
GeneCards (Weizmann)DLL3
Ensembl hg19 (Hinxton)ENSG00000090932 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090932 [Gene_View]  chr19:39498917-39508481 [Contig_View]  DLL3 [Vega]
ICGC DataPortalENSG00000090932
TCGA cBioPortalDLL3
AceView (NCBI)DLL3
Genatlas (Paris)DLL3
WikiGenes10683
SOURCE (Princeton)DLL3
Genetics Home Reference (NIH)DLL3
Genomic and cartography
GoldenPath hg38 (UCSC)DLL3  -     chr19:39498917-39508481 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLL3  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblDLL3 - 19q13.2 [CytoView hg19]  DLL3 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIDLL3 [Mapview hg19]  DLL3 [Mapview hg38]
OMIM277300   602768   
Gene and transcription
Genbank (Entrez)AA865362 AK075302 AK308460 BC000218 BQ420593
RefSeq transcript (Entrez)NM_016941 NM_203486
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLL3
Cluster EST : UnigeneHs.127792 [ NCBI ]
CGAP (NCI)Hs.127792
Alternative Splicing GalleryENSG00000090932
Gene ExpressionDLL3 [ NCBI-GEO ]   DLL3 [ EBI - ARRAY_EXPRESS ]   DLL3 [ SEEK ]   DLL3 [ MEM ]
Gene Expression Viewer (FireBrowse)DLL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10683
GTEX Portal (Tissue expression)DLL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYJ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYJ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYJ7
Splice isoforms : SwissVarQ9NYJ7
PhosPhoSitePlusQ9NYJ7
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    Growth_fac_rcpt_   
Domain families : Pfam (Sanger)EGF (PF00008)    hEGF (PF12661)   
Domain families : Pfam (NCBI)pfam00008    pfam12661   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)DLL3
DMDM Disease mutations10683
Blocks (Seattle)DLL3
SuperfamilyQ9NYJ7
Human Protein AtlasENSG00000090932
Peptide AtlasQ9NYJ7
HPRD04140
IPIIPI00021010   IPI00409625   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYJ7
IntAct (EBI)Q9NYJ7
FunCoupENSG00000090932
BioGRIDDLL3
STRING (EMBL)DLL3
ZODIACDLL3
Ontologies - Pathways
QuickGOQ9NYJ7
Ontology : AmiGOskeletal system development  somitogenesis  Notch binding  calcium ion binding  Notch signaling pathway  compartment pattern specification  integral component of membrane  paraxial mesoderm development  negative regulation of neurogenesis  
Ontology : EGO-EBIskeletal system development  somitogenesis  Notch binding  calcium ion binding  Notch signaling pathway  compartment pattern specification  integral component of membrane  paraxial mesoderm development  negative regulation of neurogenesis  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkDLL3
Atlas of Cancer Signalling NetworkDLL3
Wikipedia pathwaysDLL3
Orthology - Evolution
OrthoDB10683
GeneTree (enSembl)ENSG00000090932
Phylogenetic Trees/Animal Genes : TreeFamDLL3
HOVERGENQ9NYJ7
HOGENOMQ9NYJ7
Homologs : HomoloGeneDLL3
Homology/Alignments : Family Browser (UCSC)DLL3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLL3
dbVarDLL3
ClinVarDLL3
1000_GenomesDLL3 
Exome Variant ServerDLL3
ExAC (Exome Aggregation Consortium)DLL3 (select the gene name)
Genetic variants : HAPMAP10683
Genomic Variants (DGV)DLL3 [DGVbeta]
DECIPHERDLL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLL3 
Mutations
ICGC Data PortalDLL3 
TCGA Data PortalDLL3 
Broad Tumor PortalDLL3
OASIS PortalDLL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLL3
DgiDB (Drug Gene Interaction Database)DLL3
DoCM (Curated mutations)DLL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLL3 (select a term)
intoGenDLL3
Cancer3DDLL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM277300    602768   
Orphanet1042   
MedgenDLL3
Genetic Testing Registry DLL3
NextProtQ9NYJ7 [Medical]
TSGene10683
GENETestsDLL3
Target ValidationDLL3
Huge Navigator DLL3 [HugePedia]
snp3D : Map Gene to Disease10683
BioCentury BCIQDLL3
ClinGenDLL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10683
Chemical/Pharm GKB GenePA27365
Clinical trialDLL3
Miscellaneous
canSAR (ICR)DLL3 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLL3
EVEXDLL3
GoPubMedDLL3
iHOPDLL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 25 19:05:32 CEST 2017

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