Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DLL4 (delta like canonical Notch ligand 4)

Identity

Alias_namesdelta-like 4 homolog (Drosophila)
delta-like 4 (Drosophila)
Other aliasAOS6
hdelta2
HGNC (Hugo) DLL4
LocusID (NCBI) 54567
Atlas_Id 46204
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 40929333 and ends at 40939060 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DLL4   2910
Cards
Entrez_Gene (NCBI)DLL4  54567  delta like canonical Notch ligand 4
AliasesAOS6; hdelta2
GeneCards (Weizmann)DLL4
Ensembl hg19 (Hinxton)ENSG00000128917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128917 [Gene_View]  chr15:40929333-40939060 [Contig_View]  DLL4 [Vega]
ICGC DataPortalENSG00000128917
TCGA cBioPortalDLL4
AceView (NCBI)DLL4
Genatlas (Paris)DLL4
WikiGenes54567
SOURCE (Princeton)DLL4
Genetics Home Reference (NIH)DLL4
Genomic and cartography
GoldenPath hg38 (UCSC)DLL4  -     chr15:40929333-40939060 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLL4  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblDLL4 - 15q15.1 [CytoView hg19]  DLL4 - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBIDLL4 [Mapview hg19]  DLL4 [Mapview hg38]
OMIM605185   616589   
Gene and transcription
Genbank (Entrez)AB036931 AB043894 AF253468 AF279305 AI478830
RefSeq transcript (Entrez)NM_019074
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLL4
Cluster EST : UnigeneHs.511076 [ NCBI ]
CGAP (NCI)Hs.511076
Alternative Splicing GalleryENSG00000128917
Gene ExpressionDLL4 [ NCBI-GEO ]   DLL4 [ EBI - ARRAY_EXPRESS ]   DLL4 [ SEEK ]   DLL4 [ MEM ]
Gene Expression Viewer (FireBrowse)DLL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54567
GTEX Portal (Tissue expression)DLL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR61   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR61  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR61
Splice isoforms : SwissVarQ9NR61
PhosPhoSitePlusQ9NR61
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    DSL (PS51051)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)DSL    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    Growth_fac_rcpt_    Notch_ligand_N   
Domain families : Pfam (Sanger)DSL (PF01414)    EGF (PF00008)    MNNL (PF07657)   
Domain families : Pfam (NCBI)pfam01414    pfam00008    pfam07657   
Domain families : Smart (EMBL)DSL (SM00051)  EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)DLL4
DMDM Disease mutations54567
Blocks (Seattle)DLL4
SuperfamilyQ9NR61
Human Protein AtlasENSG00000128917
Peptide AtlasQ9NR61
HPRD05540
IPIIPI00015994   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR61
IntAct (EBI)Q9NR61
FunCoupENSG00000128917
BioGRIDDLL4
STRING (EMBL)DLL4
ZODIACDLL4
Ontologies - Pathways
QuickGOQ9NR61
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  angiogenesis  branching involved in blood vessel morphogenesis  blood vessel remodeling  cardiac ventricle morphogenesis  cardiac atrium morphogenesis  ventricular trabecula myocardium morphogenesis  pericardium morphogenesis  Notch binding  calcium ion binding  protein binding  plasma membrane  signal transduction  Notch signaling pathway  Notch receptor processing  visual perception  blood circulation  negative regulation of cell proliferation  negative regulation of endothelial cell migration  positive regulation of gene expression  negative regulation of gene expression  integral component of membrane  T cell differentiation  dorsal aorta morphogenesis  cellular response to vascular endothelial growth factor stimulus  cellular response to fibroblast growth factor stimulus  negative regulation of Notch signaling pathway  positive regulation of Notch signaling pathway  regulation of neurogenesis  ventral spinal cord interneuron fate commitment  regulation of neural retina development  Notch signaling involved in heart development  blood vessel lumenization  negative regulation of cell migration involved in sprouting angiogenesis  negative regulation of cell migration involved in sprouting angiogenesis  negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  positive regulation of neural precursor cell proliferation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  angiogenesis  branching involved in blood vessel morphogenesis  blood vessel remodeling  cardiac ventricle morphogenesis  cardiac atrium morphogenesis  ventricular trabecula myocardium morphogenesis  pericardium morphogenesis  Notch binding  calcium ion binding  protein binding  plasma membrane  signal transduction  Notch signaling pathway  Notch receptor processing  visual perception  blood circulation  negative regulation of cell proliferation  negative regulation of endothelial cell migration  positive regulation of gene expression  negative regulation of gene expression  integral component of membrane  T cell differentiation  dorsal aorta morphogenesis  cellular response to vascular endothelial growth factor stimulus  cellular response to fibroblast growth factor stimulus  negative regulation of Notch signaling pathway  positive regulation of Notch signaling pathway  regulation of neurogenesis  ventral spinal cord interneuron fate commitment  regulation of neural retina development  Notch signaling involved in heart development  blood vessel lumenization  negative regulation of cell migration involved in sprouting angiogenesis  negative regulation of cell migration involved in sprouting angiogenesis  negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  positive regulation of neural precursor cell proliferation  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkDLL4
Atlas of Cancer Signalling NetworkDLL4
Wikipedia pathwaysDLL4
Orthology - Evolution
OrthoDB54567
GeneTree (enSembl)ENSG00000128917
Phylogenetic Trees/Animal Genes : TreeFamDLL4
HOVERGENQ9NR61
HOGENOMQ9NR61
Homologs : HomoloGeneDLL4
Homology/Alignments : Family Browser (UCSC)DLL4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLL4
dbVarDLL4
ClinVarDLL4
1000_GenomesDLL4 
Exome Variant ServerDLL4
ExAC (Exome Aggregation Consortium)DLL4 (select the gene name)
Genetic variants : HAPMAP54567
Genomic Variants (DGV)DLL4 [DGVbeta]
DECIPHERDLL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLL4 
Mutations
ICGC Data PortalDLL4 
TCGA Data PortalDLL4 
Broad Tumor PortalDLL4
OASIS PortalDLL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DLL4
DgiDB (Drug Gene Interaction Database)DLL4
DoCM (Curated mutations)DLL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLL4 (select a term)
intoGenDLL4
Cancer3DDLL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605185    616589   
Orphanet1294    3198   
MedgenDLL4
Genetic Testing Registry DLL4
NextProtQ9NR61 [Medical]
TSGene54567
GENETestsDLL4
Target ValidationDLL4
Huge Navigator DLL4 [HugePedia]
snp3D : Map Gene to Disease54567
BioCentury BCIQDLL4
ClinGenDLL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54567
Chemical/Pharm GKB GenePA27366
Clinical trialDLL4
Miscellaneous
canSAR (ICR)DLL4 (select the gene name)
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLL4
EVEXDLL4
GoPubMedDLL4
iHOPDLL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:51:44 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.