DLST (dihydrolipoamide S-succinyltransferase)

2014-11-01 Affiliation

Identity

HGNC

DLST

LOCATION

14q24.3

LOCUSID

1743

ALIAS

DLTS,KGD2,PGL7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1743
MIM: 126063
HGNC: 2911
Ensembl: ENSG00000119689

Variants:

dbSNP: 1743
ClinVar: 1743
TCGA: ENSG00000119689
COSMIC: DLST

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000119689	ENST00000238671	B7ZAZ8
ENSG00000119689	ENST00000334220	P36957
ENSG00000119689	ENST00000334220	A0A024R6C9
ENSG00000119689	ENST00000554612	G3V498
ENSG00000119689	ENST00000554806	Q86SW4
ENSG00000119689	ENST00000555089	G3V5M3
ENSG00000119689	ENST00000555492	G3V5L9
ENSG00000119689	ENST00000555988	H0YJF9
ENSG00000119689	ENST00000556460	G3V3F0
ENSG00000119689	ENST00000626051	G3V5M3

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Citrate cycle (TCA cycle)	KEGG	ko00020
Lysine degradation	KEGG	ko00310
Citrate cycle (TCA cycle)	KEGG	hsa00020
Lysine degradation	KEGG	hsa00310
Metabolic pathways	KEGG	hsa01100
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate	KEGG	hsa_M00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA	KEGG	hsa_M00032
Citrate cycle (TCA cycle, Krebs cycle)	KEGG	M00009
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate	KEGG	M00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA	KEGG	M00032
Carbon metabolism	KEGG	hsa01200
Carbon metabolism	KEGG	ko01200
Citrate cycle (TCA cycle, Krebs cycle)	KEGG	hsa_M00009
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycle	REACTOME	R-HSA-71406
Citric acid cycle (TCA cycle)	REACTOME	R-HSA-71403
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Lysine catabolism	REACTOME	R-HSA-71064
Glyoxylate metabolism and glycine degradation	REACTOME	R-HSA-389661
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	REACTOME	R-HSA-6788656

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
11436125	2001	Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.	19
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
23475850	2013	The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.	13
12805207	2003	Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain.	9
26876595	2016	The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.	8
30929736	2019	Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas.	4
11445257	2001	No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome.	3
15038610	2004	Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association.	2
11825528	2001	[Association between DLST gene polymorphism and Alzheimer's disease].	1

Citation

Dessen P

DLST (dihydrolipoamide S-succinyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62528/dlst