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DLST (dihydrolipoamide S-succinyltransferase)

Identity

Alias (NCBI)DLTS
KGD2
PGL7
HGNC (Hugo) DLST
HGNC Alias nameDihydrolipoyllysine-residue succinyltransferase
HGNC Previous nameDLTS
HGNC Previous namedihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
LocusID (NCBI) 1743
Atlas_Id 62528
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 74881916 and ends at 74903742 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DLST (14q24.3) / ELAC2 (17p12)DLST (14q24.3) / LOC100507412 (-)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DLST   2911
Cards
Entrez_Gene (NCBI)DLST    dihydrolipoamide S-succinyltransferase
AliasesDLTS; KGD2; PGL7
GeneCards (Weizmann)DLST
Ensembl hg19 (Hinxton)ENSG00000119689 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119689 [Gene_View]  ENSG00000119689 [Sequence]  chr14:74881916-74903742 [Contig_View]  DLST [Vega]
ICGC DataPortalENSG00000119689
TCGA cBioPortalDLST
AceView (NCBI)DLST
Genatlas (Paris)DLST
SOURCE (Princeton)DLST
Genetics Home Reference (NIH)DLST
Genomic and cartography
GoldenPath hg38 (UCSC)DLST  -     chr14:74881916-74903742 +  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLST  -     14q24.3   [Description]    (hg19-Feb_2009)
GoldenPathDLST - 14q24.3 [CytoView hg19]  DLST - 14q24.3 [CytoView hg38]
ImmunoBaseENSG00000119689
Genome Data Viewer NCBIDLST [Mapview hg19]  
OMIM126063   618475   
Gene and transcription
Genbank (Entrez)AA101667 AI087261 AK289414 AK299505 AK300396
RefSeq transcript (Entrez)NM_001244883 NM_001933
Consensus coding sequences : CCDS (NCBI)DLST
Gene ExpressionDLST [ NCBI-GEO ]   DLST [ EBI - ARRAY_EXPRESS ]   DLST [ SEEK ]   DLST [ MEM ]
Gene Expression Viewer (FireBrowse)DLST [ Firebrowse - Broad ]
GenevisibleExpression of DLST in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1743
GTEX Portal (Tissue expression)DLST
Human Protein AtlasENSG00000119689-DLST [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36957   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36957  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36957
PhosPhoSitePlusP36957
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom_sf    Single_hybrid_motif    SucB   
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)   
Domain families : Pfam (NCBI)pfam00198    pfam00364   
Conserved Domain (NCBI)DLST
PDB (RSDB)6H05   
PDB Europe6H05   
PDB (PDBSum)6H05   
PDB (IMB)6H05   
Structural Biology KnowledgeBase6H05   
SCOP (Structural Classification of Proteins)6H05   
CATH (Classification of proteins structures)6H05   
SuperfamilyP36957
AlphaFold pdb e-kbP36957   
Human Protein Atlas [tissue]ENSG00000119689-DLST [tissue]
HPRD00520
Protein Interaction databases
DIP (DOE-UCLA)P36957
IntAct (EBI)P36957
BioGRIDDLST
STRING (EMBL)DLST
ZODIACDLST
Ontologies - Pathways
QuickGOP36957
Ontology : AmiGOdihydrolipoyllysine-residue succinyltransferase activity  dihydrolipoyllysine-residue succinyltransferase activity  protein binding  nucleus  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  cytosol  generation of precursor metabolites and energy  tricarboxylic acid cycle  tricarboxylic acid cycle  tricarboxylic acid cycle  2-oxoglutarate metabolic process  succinyl-CoA metabolic process  lysine catabolic process  membrane  acyltransferase activity  L-lysine catabolic process to acetyl-CoA via saccharopine  centriolar satellite  oxoglutarate dehydrogenase complex  histone succinylation  
Ontology : EGO-EBIdihydrolipoyllysine-residue succinyltransferase activity  dihydrolipoyllysine-residue succinyltransferase activity  protein binding  nucleus  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  cytosol  generation of precursor metabolites and energy  tricarboxylic acid cycle  tricarboxylic acid cycle  tricarboxylic acid cycle  2-oxoglutarate metabolic process  succinyl-CoA metabolic process  lysine catabolic process  membrane  acyltransferase activity  L-lysine catabolic process to acetyl-CoA via saccharopine  centriolar satellite  oxoglutarate dehydrogenase complex  histone succinylation  
Pathways : KEGGCitrate cycle (TCA cycle)    Lysine degradation   
NDEx NetworkDLST
Atlas of Cancer Signalling NetworkDLST
Wikipedia pathwaysDLST
Orthology - Evolution
OrthoDB1743
GeneTree (enSembl)ENSG00000119689
Phylogenetic Trees/Animal Genes : TreeFamDLST
Homologs : HomoloGeneDLST
Homology/Alignments : Family Browser (UCSC)DLST
Gene fusions - Rearrangements
Fusion : QuiverDLST
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLST [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLST
dbVarDLST
ClinVarDLST
MonarchDLST
1000_GenomesDLST 
Exome Variant ServerDLST
GNOMAD BrowserENSG00000119689
Varsome BrowserDLST
ACMGDLST variants
VarityP36957
Genomic Variants (DGV)DLST [DGVbeta]
DECIPHERDLST [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLST 
Mutations
ICGC Data PortalDLST 
TCGA Data PortalDLST 
Broad Tumor PortalDLST
OASIS PortalDLST [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLST  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDLST
Mutations and Diseases : HGMDDLST
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDLST
DgiDB (Drug Gene Interaction Database)DLST
DoCM (Curated mutations)DLST
CIViC (Clinical Interpretations of Variants in Cancer)DLST
Cancer3DDLST
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126063    618475   
Orphanet
DisGeNETDLST
MedgenDLST
Genetic Testing Registry DLST
NextProtP36957 [Medical]
GENETestsDLST
Target ValidationDLST
Huge Navigator DLST [HugePedia]
ClinGenDLST
Clinical trials, drugs, therapy
MyCancerGenomeDLST
Protein Interactions : CTDDLST
Pharm GKB GenePA27367
PharosP36957
Clinical trialDLST
Miscellaneous
canSAR (ICR)DLST
HarmonizomeDLST
DataMed IndexDLST
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDLST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:48:02 CEST 2021

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