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DLST (dihydrolipoamide S-succinyltransferase)

Identity

Alias_namesDLTS
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Other alias
HGNC (Hugo) DLST
LocusID (NCBI) 1743
Atlas_Id 62528
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 74881891 and ends at 74891891 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DLST (14q24.3) / ELAC2 (17p12)DLST (14q24.3) / LOC100507412 (-)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DLST   2911
Cards
Entrez_Gene (NCBI)DLST  1743  dihydrolipoamide S-succinyltransferase
AliasesDLTS
GeneCards (Weizmann)DLST
Ensembl hg19 (Hinxton)ENSG00000119689 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119689 [Gene_View]  chr14:74881891-74891891 [Contig_View]  DLST [Vega]
ICGC DataPortalENSG00000119689
TCGA cBioPortalDLST
AceView (NCBI)DLST
Genatlas (Paris)DLST
WikiGenes1743
SOURCE (Princeton)DLST
Genetics Home Reference (NIH)DLST
Genomic and cartography
GoldenPath hg38 (UCSC)DLST  -     chr14:74881891-74891891 +  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLST  -     14q24.3   [Description]    (hg19-Feb_2009)
EnsemblDLST - 14q24.3 [CytoView hg19]  DLST - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIDLST [Mapview hg19]  DLST [Mapview hg38]
OMIM126063   
Gene and transcription
Genbank (Entrez)AA101667 AI087261 AK289414 AK299505 AK300396
RefSeq transcript (Entrez)NM_001244883 NM_001933
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLST
Cluster EST : UnigeneHs.525459 [ NCBI ]
CGAP (NCI)Hs.525459
Alternative Splicing GalleryENSG00000119689
Gene ExpressionDLST [ NCBI-GEO ]   DLST [ EBI - ARRAY_EXPRESS ]   DLST [ SEEK ]   DLST [ MEM ]
Gene Expression Viewer (FireBrowse)DLST [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1743
GTEX Portal (Tissue expression)DLST
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36957   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36957  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36957
Splice isoforms : SwissVarP36957
Catalytic activity : Enzyme2.3.1.61 [ Enzyme-Expasy ]   2.3.1.612.3.1.61 [ IntEnz-EBI ]   2.3.1.61 [ BRENDA ]   2.3.1.61 [ KEGG ]   
PhosPhoSitePlusP36957
Domaine pattern : Prosite (Expaxy)BIOTINYL_LIPOYL (PS50968)    LIPOYL (PS00189)   
Domains : Interpro (EBI)2-oxoA_DH_lipoyl-BS    2-oxoacid_DH_actylTfrase    Biotin_lipoyl    CAT-like_dom    Single_hybrid_motif    SucB   
Domain families : Pfam (Sanger)2-oxoacid_dh (PF00198)    Biotin_lipoyl (PF00364)   
Domain families : Pfam (NCBI)pfam00198    pfam00364   
Conserved Domain (NCBI)DLST
DMDM Disease mutations1743
Blocks (Seattle)DLST
SuperfamilyP36957
Human Protein AtlasENSG00000119689
Peptide AtlasP36957
HPRD00520
Protein Interaction databases
DIP (DOE-UCLA)P36957
IntAct (EBI)P36957
FunCoupENSG00000119689
BioGRIDDLST
STRING (EMBL)DLST
ZODIACDLST
Ontologies - Pathways
QuickGOP36957
Ontology : AmiGOdihydrolipoyllysine-residue succinyltransferase activity  nucleus  mitochondrial matrix  generation of precursor metabolites and energy  tricarboxylic acid cycle  lysine catabolic process  membrane  L-lysine catabolic process to acetyl-CoA via saccharopine  myelin sheath  oxoglutarate dehydrogenase complex  glyoxylate metabolic process  extracellular exosome  
Ontology : EGO-EBIdihydrolipoyllysine-residue succinyltransferase activity  nucleus  mitochondrial matrix  generation of precursor metabolites and energy  tricarboxylic acid cycle  lysine catabolic process  membrane  L-lysine catabolic process to acetyl-CoA via saccharopine  myelin sheath  oxoglutarate dehydrogenase complex  glyoxylate metabolic process  extracellular exosome  
Pathways : KEGGCitrate cycle (TCA cycle)    Lysine degradation   
NDEx NetworkDLST
Atlas of Cancer Signalling NetworkDLST
Wikipedia pathwaysDLST
Orthology - Evolution
OrthoDB1743
GeneTree (enSembl)ENSG00000119689
Phylogenetic Trees/Animal Genes : TreeFamDLST
HOVERGENP36957
HOGENOMP36957
Homologs : HomoloGeneDLST
Homology/Alignments : Family Browser (UCSC)DLST
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLST [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLST
dbVarDLST
ClinVarDLST
1000_GenomesDLST 
Exome Variant ServerDLST
ExAC (Exome Aggregation Consortium)DLST (select the gene name)
Genetic variants : HAPMAP1743
Genomic Variants (DGV)DLST [DGVbeta]
DECIPHERDLST [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLST 
Mutations
ICGC Data PortalDLST 
TCGA Data PortalDLST 
Broad Tumor PortalDLST
OASIS PortalDLST [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLST  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLST
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DLST
DgiDB (Drug Gene Interaction Database)DLST
DoCM (Curated mutations)DLST (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLST (select a term)
intoGenDLST
Cancer3DDLST(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126063   
Orphanet
MedgenDLST
Genetic Testing Registry DLST
NextProtP36957 [Medical]
TSGene1743
GENETestsDLST
Huge Navigator DLST [HugePedia]
snp3D : Map Gene to Disease1743
BioCentury BCIQDLST
ClinGenDLST
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1743
Chemical/Pharm GKB GenePA27367
Clinical trialDLST
Miscellaneous
canSAR (ICR)DLST (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLST
EVEXDLST
GoPubMedDLST
iHOPDLST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:08:37 CEST 2017

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