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DLX1 (distal-less homeobox 1)

Identity

Other alias-
HGNC (Hugo) DLX1
LocusID (NCBI) 1745
Atlas_Id 56850
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 172085480 and ends at 172089673 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DLX1   2914
Cards
Entrez_Gene (NCBI)DLX1  1745  distal-less homeobox 1
Aliases
GeneCards (Weizmann)DLX1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:172085480-172089673 [Contig_View]  DLX1 [Vega]
TCGA cBioPortalDLX1
AceView (NCBI)DLX1
Genatlas (Paris)DLX1
WikiGenes1745
SOURCE (Princeton)DLX1
Genetics Home Reference (NIH)DLX1
Genomic and cartography
GoldenPath hg38 (UCSC)DLX1  -     chr2:172085480-172089673 +  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLX1  -     2q31.1   [Description]    (hg19-Feb_2009)
EnsemblDLX1 - 2q31.1 [CytoView hg19]  DLX1 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBIDLX1 [Mapview hg19]  DLX1 [Mapview hg38]
OMIM600029   
Gene and transcription
Genbank (Entrez)AK095266 AK290503 AK308842 AY257976 BC013010
RefSeq transcript (Entrez)NM_001038493 NM_178120
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DLX1
Cluster EST : UnigeneHs.407015 [ NCBI ]
CGAP (NCI)Hs.407015
Gene ExpressionDLX1 [ NCBI-GEO ]   DLX1 [ EBI - ARRAY_EXPRESS ]   DLX1 [ SEEK ]   DLX1 [ MEM ]
Gene Expression Viewer (FireBrowse)DLX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1745
GTEX Portal (Tissue expression)DLX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56177   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56177  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56177
Splice isoforms : SwissVarP56177
PhosPhoSitePlusP56177
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)DLX1
DMDM Disease mutations1745
Blocks (Seattle)DLX1
SuperfamilyP56177
Peptide AtlasP56177
IPIIPI00221129   IPI00383909   IPI00916446   IPI01022499   IPI01022976   IPI00644347   
Protein Interaction databases
DIP (DOE-UCLA)P56177
IntAct (EBI)P56177
BioGRIDDLX1
STRING (EMBL)DLX1
ZODIACDLX1
Ontologies - Pathways
QuickGOP56177
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  protein binding  nucleus  transcription, DNA-templated  proximal/distal pattern formation  subpallium development  hippocampus development  regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment  cerebral cortex GABAergic interneuron fate commitment  negative regulation of BMP signaling pathway  odontogenesis of dentin-containing tooth  negative regulation of neuron apoptotic process  positive regulation of cell differentiation  negative regulation of Notch signaling pathway  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  negative regulation of photoreceptor cell differentiation  embryonic skeletal system development  negative regulation of oligodendrocyte differentiation  cellular response to transforming growth factor beta stimulus  cellular response to BMP stimulus  positive regulation of amacrine cell differentiation  negative regulation of cellular response to transforming growth factor beta stimulus  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  protein binding  nucleus  transcription, DNA-templated  proximal/distal pattern formation  subpallium development  hippocampus development  regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment  cerebral cortex GABAergic interneuron fate commitment  negative regulation of BMP signaling pathway  odontogenesis of dentin-containing tooth  negative regulation of neuron apoptotic process  positive regulation of cell differentiation  negative regulation of Notch signaling pathway  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  negative regulation of photoreceptor cell differentiation  embryonic skeletal system development  negative regulation of oligodendrocyte differentiation  cellular response to transforming growth factor beta stimulus  cellular response to BMP stimulus  positive regulation of amacrine cell differentiation  negative regulation of cellular response to transforming growth factor beta stimulus  
NDEx NetworkDLX1
Atlas of Cancer Signalling NetworkDLX1
Wikipedia pathwaysDLX1
Orthology - Evolution
OrthoDB1745
Phylogenetic Trees/Animal Genes : TreeFamDLX1
HOVERGENP56177
HOGENOMP56177
Homologs : HomoloGeneDLX1
Homology/Alignments : Family Browser (UCSC)DLX1
Gene fusions - Rearrangements
Tumor Fusion PortalDLX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLX1
dbVarDLX1
ClinVarDLX1
1000_GenomesDLX1 
Exome Variant ServerDLX1
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP1745
Genomic Variants (DGV)DLX1 [DGVbeta]
DECIPHERDLX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLX1 
Mutations
ICGC Data PortalDLX1 
TCGA Data PortalDLX1 
Broad Tumor PortalDLX1
OASIS PortalDLX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDLX1
BioMutasearch DLX1
DgiDB (Drug Gene Interaction Database)DLX1
DoCM (Curated mutations)DLX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DLX1 (select a term)
intoGenDLX1
Cancer3DDLX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600029   
Orphanet
DisGeNETDLX1
MedgenDLX1
Genetic Testing Registry DLX1
NextProtP56177 [Medical]
TSGene1745
GENETestsDLX1
Target ValidationDLX1
Huge Navigator DLX1 [HugePedia]
snp3D : Map Gene to Disease1745
BioCentury BCIQDLX1
ClinGenDLX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1745
Chemical/Pharm GKB GenePA27369
Clinical trialDLX1
Miscellaneous
canSAR (ICR)DLX1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDLX1
EVEXDLX1
GoPubMedDLX1
iHOPDLX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Nov 20 20:34:11 CET 2017

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