DLX1 (distal-less homeobox 1)

2017-04-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 1745
MIM: 600029
HGNC: 2914
Ensembl: ENSG00000144355

Variants:

dbSNP: 1745
ClinVar: 1745
TCGA: ENSG00000144355
COSMIC: DLX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144355ENST00000341900P56177
ENSG00000144355ENST00000361609J3KP55
ENSG00000144355ENST00000361725P56177
ENSG00000144355ENST00000361725X5D2F9
ENSG00000144355ENST00000469444F8VXJ2

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
233125182013Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.59
271081622016Detection of High-grade Prostate Cancer Using a Urinary Molecular Biomarker-Based Risk Score.52
183840592008Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene.44
187286932009The DLX1and DLX2 genes and susceptibility to autism spectrum disorders.37
187286932009The DLX1and DLX2 genes and susceptibility to autism spectrum disorders.37
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
146713212003Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells.15
275939332017DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling.10

Citation

Dessen P

DLX1 (distal-less homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56850/dlx1