Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DLX2 (distal-less homeobox 2)

Identity

Other namesTES-1
TES1
HGNC (Hugo) DLX2
LocusID (NCBI) 1746
Location 2q31.1
Location_base_pair Starts at 172964166 and ends at 172967478 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)DLX2   2915
Cards
Entrez_Gene (NCBI)DLX2  1746  distal-less homeobox 2
GeneCards (Weizmann)DLX2
Ensembl (Hinxton)ENSG00000115844 [Gene_View]  chr2:172964166-172967478 [Contig_View]  DLX2 [Vega]
ICGC DataPortalENSG00000115844
cBioPortalDLX2
AceView (NCBI)DLX2
Genatlas (Paris)DLX2
WikiGenes1746
SOURCE (Princeton)NM_004405
Genomic and cartography
GoldenPath (UCSC)DLX2  -  2q31.1   chr2:172964166-172967478 -  2q31.1   [Description]    (hg19-Feb_2009)
EnsemblDLX2 - 2q31.1 [CytoView]
Mapping of homologs : NCBIDLX2 [Mapview]
OMIM126255   
Gene and transcription
Genbank (Entrez)AA912071 AB208823 AK291367 AK297503 AK316129
RefSeq transcript (Entrez)NM_004405
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_009219 NT_005403 NW_001838862 NW_004929305
Consensus coding sequences : CCDS (NCBI)DLX2
Cluster EST : UnigeneHs.419 [ NCBI ]
CGAP (NCI)Hs.419
Alternative Splicing : Fast-db (Paris)GSHG0018153
Alternative Splicing GalleryENSG00000115844
Gene ExpressionDLX2 [ NCBI-GEO ]     DLX2 [ SEEK ]   DLX2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07687 (Uniprot)
NextProtQ07687  [Medical]
With graphics : InterProQ07687
Splice isoforms : SwissVarQ07687 (Swissvar)
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Distal-less_N [organisation]   Homeobox_CS [organisation]   Homeobox_dom [organisation]   Homeobox_metazoa [organisation]   Homeodomain-like [organisation]   HTH_motif [organisation]  
Related proteins : CluSTrQ07687
Domain families : Pfam (Sanger)DLL_N (PF12413)    Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam12413    pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations1746
Blocks (Seattle)Q07687
Human Protein AtlasENSG00000115844 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ07687
HPRD00527
IPIIPI00018974   IPI00556089   IPI00910860   
Protein Interaction databases
DIP (DOE-UCLA)Q07687
IntAct (EBI)Q07687
FunCoupENSG00000115844
BioGRIDDLX2
InParanoidQ07687
Interologous Interaction database Q07687
IntegromeDBDLX2
STRING (EMBL)DLX2
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcription regulatory region sequence-specific DNA binding  chromatin binding  sequence-specific DNA binding transcription factor activity  single-stranded RNA binding  nucleus  brain development  proximal/distal pattern formation  subpallium development  hippocampus development  olfactory bulb development  regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment  cerebral cortex GABAergic interneuron fate commitment  odontogenesis of dentin-containing tooth  negative regulation of Notch signaling pathway  positive regulation of transcription from RNA polymerase II promoter  embryonic cranial skeleton morphogenesis  negative regulation of oligodendrocyte differentiation  branching morphogenesis of a nerve  cartilage development  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcription regulatory region sequence-specific DNA binding  chromatin binding  sequence-specific DNA binding transcription factor activity  single-stranded RNA binding  nucleus  brain development  proximal/distal pattern formation  subpallium development  hippocampus development  olfactory bulb development  regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment  cerebral cortex GABAergic interneuron fate commitment  odontogenesis of dentin-containing tooth  negative regulation of Notch signaling pathway  positive regulation of transcription from RNA polymerase II promoter  embryonic cranial skeleton morphogenesis  negative regulation of oligodendrocyte differentiation  branching morphogenesis of a nerve  cartilage development  
Protein Interaction DatabaseDLX2
Wikipedia pathwaysDLX2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DLX2
snp3D : Map Gene to Disease1746
SNP (GeneSNP Utah)DLX2
SNP : HGBaseDLX2
Genetic variants : HAPMAPDLX2
Exome VariantDLX2
1000_GenomesDLX2 
ICGC programENSG00000115844 
Somatic Mutations in Cancer : COSMICDLX2 
CONAN: Copy Number AnalysisDLX2 
Mutations and Diseases : HGMDDLX2
Genomic VariantsDLX2  DLX2 [DGVbeta]
dbVarDLX2
ClinVarDLX2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM126255   
MedgenDLX2
GENETestsDLX2
Disease Genetic AssociationDLX2
Huge Navigator DLX2 [HugePedia]  DLX2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneDLX2
Homology/Alignments : Family Browser (UCSC)DLX2
Phylogenetic Trees/Animal Genes : TreeFamDLX2
Chemical/Protein Interactions : CTD1746
Chemical/Pharm GKB GenePA27370
Clinical trialDLX2
Cancer Resource (Charite)ENSG00000115844
Other databases
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
CoreMineDLX2
iHOPDLX2
OncoSearchDLX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:29:49 CEST 2014

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