Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DLX3 (distal-less homeobox 3)

Identity

Alias (NCBI)AI4
TDO
HGNC (Hugo) DLX3
HGNC Previous namedistal-less homeo box 3
LocusID (NCBI) 1747
Atlas_Id 49723
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 49990005 and ends at 49995224 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DLX3   2916
Cards
Entrez_Gene (NCBI)DLX3    distal-less homeobox 3
AliasesAI4; TDO
GeneCards (Weizmann)DLX3
Ensembl hg19 (Hinxton)ENSG00000064195 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000064195 [Gene_View]  ENSG00000064195 [Sequence]  chr17:49990005-49995224 [Contig_View]  DLX3 [Vega]
ICGC DataPortalENSG00000064195
TCGA cBioPortalDLX3
AceView (NCBI)DLX3
Genatlas (Paris)DLX3
SOURCE (Princeton)DLX3
Genetics Home Reference (NIH)DLX3
Genomic and cartography
GoldenPath hg38 (UCSC)DLX3  -     chr17:49990005-49995224 -  17q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DLX3  -     17q21.33   [Description]    (hg19-Feb_2009)
GoldenPathDLX3 - 17q21.33 [CytoView hg19]  DLX3 - 17q21.33 [CytoView hg38]
ImmunoBaseENSG00000064195
Genome Data Viewer NCBIDLX3 [Mapview hg19]  
OMIM104510   190320   600525   
Gene and transcription
Genbank (Entrez)AA604314 AK075167 AK313257 BC012361 BC028970
RefSeq transcript (Entrez)NM_005220
Consensus coding sequences : CCDS (NCBI)DLX3
Gene ExpressionDLX3 [ NCBI-GEO ]   DLX3 [ EBI - ARRAY_EXPRESS ]   DLX3 [ SEEK ]   DLX3 [ MEM ]
Gene Expression Viewer (FireBrowse)DLX3 [ Firebrowse - Broad ]
GenevisibleExpression of DLX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1747
GTEX Portal (Tissue expression)DLX3
Human Protein AtlasENSG00000064195-DLX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60479   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60479  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60479
PhosPhoSitePlusO60479
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Distal-less_N    Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)DLL_N (PF12413)    Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam12413    pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)DLX3
PDB (RSDB)4XRS   
PDB Europe4XRS   
PDB (PDBSum)4XRS   
PDB (IMB)4XRS   
Structural Biology KnowledgeBase4XRS   
SCOP (Structural Classification of Proteins)4XRS   
CATH (Classification of proteins structures)4XRS   
SuperfamilyO60479
AlphaFold pdb e-kbO60479   
Human Protein Atlas [tissue]ENSG00000064195-DLX3 [tissue]
HPRD02752
Protein Interaction databases
DIP (DOE-UCLA)O60479
IntAct (EBI)O60479
BioGRIDDLX3
STRING (EMBL)DLX3
ZODIACDLX3
Ontologies - Pathways
QuickGOO60479
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  blood vessel development  placenta development  DNA binding  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  regulation of transcription by RNA polymerase II  embryo development  cell differentiation  epithelial cell differentiation  odontogenesis of dentin-containing tooth  positive regulation of transcription by RNA polymerase II  odontoblast differentiation  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  blood vessel development  placenta development  DNA binding  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  regulation of transcription by RNA polymerase II  embryo development  cell differentiation  epithelial cell differentiation  odontogenesis of dentin-containing tooth  positive regulation of transcription by RNA polymerase II  odontoblast differentiation  sequence-specific double-stranded DNA binding  
NDEx NetworkDLX3
Atlas of Cancer Signalling NetworkDLX3
Wikipedia pathwaysDLX3
Orthology - Evolution
OrthoDB1747
GeneTree (enSembl)ENSG00000064195
Phylogenetic Trees/Animal Genes : TreeFamDLX3
Homologs : HomoloGeneDLX3
Homology/Alignments : Family Browser (UCSC)DLX3
Gene fusions - Rearrangements
Fusion : QuiverDLX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDLX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DLX3
dbVarDLX3
ClinVarDLX3
MonarchDLX3
1000_GenomesDLX3 
Exome Variant ServerDLX3
GNOMAD BrowserENSG00000064195
Varsome BrowserDLX3
ACMGDLX3 variants
VarityO60479
Genomic Variants (DGV)DLX3 [DGVbeta]
DECIPHERDLX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDLX3 
Mutations
ICGC Data PortalDLX3 
TCGA Data PortalDLX3 
Broad Tumor PortalDLX3
OASIS PortalDLX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDLX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDLX3
Mutations and Diseases : HGMDDLX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDLX3
DgiDB (Drug Gene Interaction Database)DLX3
DoCM (Curated mutations)DLX3
CIViC (Clinical Interpretations of Variants in Cancer)DLX3
Cancer3DDLX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104510    190320    600525   
Orphanet2971    14607   
DisGeNETDLX3
MedgenDLX3
Genetic Testing Registry DLX3
NextProtO60479 [Medical]
GENETestsDLX3
Target ValidationDLX3
Huge Navigator DLX3 [HugePedia]
ClinGenDLX3
Clinical trials, drugs, therapy
MyCancerGenomeDLX3
Protein Interactions : CTDDLX3
Pharm GKB GenePA27371
PharosO60479
Clinical trialDLX3
Miscellaneous
canSAR (ICR)DLX3
HarmonizomeDLX3
DataMed IndexDLX3
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDLX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:06:53 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.