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DMGDH (dimethylglycine dehydrogenase)

Identity

Other aliasDMGDHD
ME2GLYDH
HGNC (Hugo) DMGDH
LocusID (NCBI) 29958
Atlas_Id 54257
Location 5q14.1  [Link to chromosome band 5q14]
Location_base_pair Starts at 78997564 and ends at 79069674 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARSB (5q14.1) / DMGDH (5q14.1)DMGDH (5q14.1) / NMNAT2 (1q25.3)JMY (5q14.1) / DMGDH (5q14.1)
DMGDH 5q14.1 / NMNAT2 1q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DMGDH   24475
Cards
Entrez_Gene (NCBI)DMGDH  29958  dimethylglycine dehydrogenase
AliasesDMGDHD; ME2GLYDH
GeneCards (Weizmann)DMGDH
Ensembl hg19 (Hinxton)ENSG00000132837 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132837 [Gene_View]  chr5:78997564-79069674 [Contig_View]  DMGDH [Vega]
ICGC DataPortalENSG00000132837
TCGA cBioPortalDMGDH
AceView (NCBI)DMGDH
Genatlas (Paris)DMGDH
WikiGenes29958
SOURCE (Princeton)DMGDH
Genetics Home Reference (NIH)DMGDH
Genomic and cartography
GoldenPath hg38 (UCSC)DMGDH  -     chr5:78997564-79069674 -  5q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DMGDH  -     5q14.1   [Description]    (hg19-Feb_2009)
EnsemblDMGDH - 5q14.1 [CytoView hg19]  DMGDH - 5q14.1 [CytoView hg38]
Mapping of homologs : NCBIDMGDH [Mapview hg19]  DMGDH [Mapview hg38]
OMIM605849   605850   
Gene and transcription
Genbank (Entrez)AA676742 AF111858 AI302996 AI469206 AK057641
RefSeq transcript (Entrez)NM_013391
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DMGDH
Cluster EST : UnigeneHs.655653 [ NCBI ]
CGAP (NCI)Hs.655653
Alternative Splicing GalleryENSG00000132837
Gene ExpressionDMGDH [ NCBI-GEO ]   DMGDH [ EBI - ARRAY_EXPRESS ]   DMGDH [ SEEK ]   DMGDH [ MEM ]
Gene Expression Viewer (FireBrowse)DMGDH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29958
GTEX Portal (Tissue expression)DMGDH
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UI17   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UI17  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UI17
Splice isoforms : SwissVarQ9UI17
PhosPhoSitePlusQ9UI17
Domains : Interpro (EBI)FAD-dep_OxRdtase    FAD/NAD-binding_dom    FAO_M    GCV_T_C    GCV_T_N    GcvT/YgfZ_C    TrmE/GcvT_dom1   
Domain families : Pfam (Sanger)DAO (PF01266)    FAO_M (PF16350)    GCV_T (PF01571)    GCV_T_C (PF08669)   
Domain families : Pfam (NCBI)pfam01266    pfam16350    pfam01571    pfam08669   
Conserved Domain (NCBI)DMGDH
DMDM Disease mutations29958
Blocks (Seattle)DMGDH
PDB (SRS)5L46   
PDB (PDBSum)5L46   
PDB (IMB)5L46   
PDB (RSDB)5L46   
Structural Biology KnowledgeBase5L46   
SCOP (Structural Classification of Proteins)5L46   
CATH (Classification of proteins structures)5L46   
SuperfamilyQ9UI17
Human Protein AtlasENSG00000132837
Peptide AtlasQ9UI17
HPRD05789
IPIIPI00296196   IPI00178676   IPI01013014   IPI00985114   IPI00974557   IPI00973812   IPI00974067   
Protein Interaction databases
DIP (DOE-UCLA)Q9UI17
IntAct (EBI)Q9UI17
FunCoupENSG00000132837
BioGRIDDMGDH
STRING (EMBL)DMGDH
ZODIACDMGDH
Ontologies - Pathways
QuickGOQ9UI17
Ontology : AmiGORNA binding  mitochondrion  mitochondrial matrix  mitochondrial matrix  mitochondrial matrix  glycine metabolic process  amino-acid betaine catabolic process  electron carrier activity  choline metabolic process  choline catabolic process  dimethylglycine dehydrogenase activity  dimethylglycine dehydrogenase activity  oxidation-reduction process  
Ontology : EGO-EBIRNA binding  mitochondrion  mitochondrial matrix  mitochondrial matrix  mitochondrial matrix  glycine metabolic process  amino-acid betaine catabolic process  electron carrier activity  choline metabolic process  choline catabolic process  dimethylglycine dehydrogenase activity  dimethylglycine dehydrogenase activity  oxidation-reduction process  
Pathways : KEGGGlycine, serine and threonine metabolism   
NDEx NetworkDMGDH
Atlas of Cancer Signalling NetworkDMGDH
Wikipedia pathwaysDMGDH
Orthology - Evolution
OrthoDB29958
GeneTree (enSembl)ENSG00000132837
Phylogenetic Trees/Animal Genes : TreeFamDMGDH
HOVERGENQ9UI17
HOGENOMQ9UI17
Homologs : HomoloGeneDMGDH
Homology/Alignments : Family Browser (UCSC)DMGDH
Gene fusions - Rearrangements
Fusion : MitelmanARSB/DMGDH [5q14.1/5q14.1]  [t(5;5)(q14;q14)]  
Fusion : MitelmanDMGDH/NMNAT2 [5q14.1/1q25.3]  [t(1;5)(q25;q14)]  
Fusion : MitelmanJMY/DMGDH [5q14.1/5q14.1]  [t(5;5)(q14;q14)]  
Fusion: TCGADMGDH 5q14.1 NMNAT2 1q25.3 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDMGDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DMGDH
dbVarDMGDH
ClinVarDMGDH
1000_GenomesDMGDH 
Exome Variant ServerDMGDH
ExAC (Exome Aggregation Consortium)DMGDH (select the gene name)
Genetic variants : HAPMAP29958
Genomic Variants (DGV)DMGDH [DGVbeta]
DECIPHERDMGDH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDMGDH 
Mutations
ICGC Data PortalDMGDH 
TCGA Data PortalDMGDH 
Broad Tumor PortalDMGDH
OASIS PortalDMGDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDMGDH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDMGDH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DMGDH
DgiDB (Drug Gene Interaction Database)DMGDH
DoCM (Curated mutations)DMGDH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DMGDH (select a term)
intoGenDMGDH
Cancer3DDMGDH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605849    605850   
Orphanet19468   
MedgenDMGDH
Genetic Testing Registry DMGDH
NextProtQ9UI17 [Medical]
TSGene29958
GENETestsDMGDH
Target ValidationDMGDH
Huge Navigator DMGDH [HugePedia]
snp3D : Map Gene to Disease29958
BioCentury BCIQDMGDH
ClinGenDMGDH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29958
Chemical/Pharm GKB GenePA134947212
Clinical trialDMGDH
Miscellaneous
canSAR (ICR)DMGDH (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDMGDH
EVEXDMGDH
GoPubMedDMGDH
iHOPDMGDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:05:34 CEST 2017

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