| Nomenclature |
|---|
| HGNC (Hugo) | DMRT1 2934 |
| Cards |
|---|
| Entrez_Gene (NCBI) | DMRT1 1761 doublesex and mab-3 related transcription factor 1 |
| Aliases | CT154; DMT1 |
| GeneCards (Weizmann) | DMRT1 |
| Ensembl hg19 (Hinxton) | ENSG00000137090 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000137090 [Gene_View] ENSG00000137090 [Sequence] chr9:841690-969091 [Contig_View] DMRT1 [Vega] |
| ICGC DataPortal | ENSG00000137090 |
| TCGA cBioPortal | DMRT1 |
| AceView (NCBI) | DMRT1 |
| Genatlas (Paris) | DMRT1 |
| WikiGenes | 1761 |
| SOURCE (Princeton) | DMRT1 |
| Genetics Home Reference (NIH) | DMRT1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | DMRT1 - chr9:841690-969091 + 9p24.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | DMRT1 - 9p24.3 [Description] (hg19-Feb_2009) |
| Ensembl | DMRT1 - 9p24.3 [CytoView hg19] DMRT1 - 9p24.3 [CytoView hg38] |
| Mapping of homologs : NCBI | DMRT1 [Mapview hg19] DMRT1 [Mapview hg38] |
| OMIM | 602424 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF130728 AJ276801 AK310336 AK313594 AL162131 |
| RefSeq transcript (Entrez) | NM_001363767 NM_021951 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | DMRT1 |
| Cluster EST : Unigene | Hs.98586 [ NCBI ] |
| CGAP (NCI) | Hs.98586 |
| Alternative Splicing Gallery | ENSG00000137090 |
| Gene Expression | DMRT1 [ NCBI-GEO ] DMRT1 [ EBI - ARRAY_EXPRESS ]
DMRT1 [ SEEK ] DMRT1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | DMRT1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1761 |
| GTEX Portal (Tissue expression) | DMRT1 |
| Human Protein Atlas | ENSG00000137090-DMRT1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9Y5R6 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9Y5R6 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9Y5R6 |
| Splice isoforms : SwissVar | Q9Y5R6 |
| PhosPhoSitePlus | Q9Y5R6 |
| Domaine pattern : Prosite (Expaxy) | DM_1 (PS40000) DM_2 (PS50809) |
| Domains : Interpro (EBI) | DM_DNA-bd DM_DNA-bd_sf DMRT/dsx/mab-3 DMRT1-like |
| Domain families : Pfam (Sanger) | DM (PF00751) Dmrt1 (PF12374) |
| Domain families : Pfam (NCBI) | pfam00751 pfam12374 |
| Domain families : Smart (EMBL) | DM (SM00301) |
| Conserved Domain (NCBI) | DMRT1 |
| DMDM Disease mutations | 1761 |
| Blocks (Seattle) | DMRT1 |
| PDB (SRS) | 4YJ0 |
| PDB (PDBSum) | 4YJ0 |
| PDB (IMB) | 4YJ0 |
| PDB (RSDB) | 4YJ0 |
| Structural Biology KnowledgeBase | 4YJ0 |
| SCOP (Structural Classification of Proteins) | 4YJ0 |
| CATH (Classification of proteins structures) | 4YJ0 |
| Superfamily | Q9Y5R6 |
| Human Protein Atlas [tissue] | ENSG00000137090-DMRT1 [tissue] |
| Peptide Atlas | Q9Y5R6 |
| HPRD | 03885 |
| IPI | IPI00001733 IPI00445344 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9Y5R6 |
| IntAct (EBI) | Q9Y5R6 |
| FunCoup | ENSG00000137090 |
| BioGRID | DMRT1 |
| STRING (EMBL) | DMRT1 |
| ZODIAC | DMRT1 |
| Ontologies - Pathways |
|---|
| QuickGO | Q9Y5R6 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding proximal promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding male germ cell proliferation male germ cell proliferation chromatin binding DNA-binding transcription factor activity nucleus nucleus nucleus cytoplasm transcription by RNA polymerase II spermatogenesis sex differentiation germ cell migration male sex determination intracellular signal transduction identical protein binding protein homodimerization activity protein homodimerization activity negative regulation of meiotic nuclear division negative regulation of meiotic nuclear division positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II male sex differentiation metal ion binding protein heterodimerization activity protein heterodimerization activity oocyte development oocyte development Sertoli cell differentiation Sertoli cell development positive regulation of meiosis I positive regulation of meiosis I regulation of nodal signaling pathway positive regulation of male gonad development |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding proximal promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding male germ cell proliferation male germ cell proliferation chromatin binding DNA-binding transcription factor activity nucleus nucleus nucleus cytoplasm transcription by RNA polymerase II spermatogenesis sex differentiation germ cell migration male sex determination intracellular signal transduction identical protein binding protein homodimerization activity protein homodimerization activity negative regulation of meiotic nuclear division negative regulation of meiotic nuclear division positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II male sex differentiation metal ion binding protein heterodimerization activity protein heterodimerization activity oocyte development oocyte development Sertoli cell differentiation Sertoli cell development positive regulation of meiosis I positive regulation of meiosis I regulation of nodal signaling pathway positive regulation of male gonad development |
| NDEx Network | DMRT1 |
| Atlas of Cancer Signalling Network | DMRT1 |
| Wikipedia pathways | DMRT1 |
| Orthology - Evolution |
|---|
| OrthoDB | 1761 |
| GeneTree (enSembl) | ENSG00000137090 |
| Phylogenetic Trees/Animal Genes : TreeFam | DMRT1 |
| HOVERGEN | Q9Y5R6 |
| HOGENOM | Q9Y5R6 |
| Homologs : HomoloGene | DMRT1 |
| Homology/Alignments : Family Browser (UCSC) | DMRT1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | DMRT1/BCL6 [9p24.3/3q27.3] |
| Fusion : Mitelman | SMARCA2/DMRT1 [9p24.3/9p24.3] [t(9;9)(p24;p24)] |
| Fusion Portal | SMARCA2 9p24.3 DMRT1 9p24.3 HNSC |
| Fusion : Quiver | DMRT1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | DMRT1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | DMRT1 |
| dbVar | DMRT1 |
| ClinVar | DMRT1 |
| 1000_Genomes | DMRT1 |
| Exome Variant Server | DMRT1 |
| ExAC (Exome Aggregation Consortium) | ENSG00000137090 |
| GNOMAD Browser | ENSG00000137090 |
| Varsome Browser | DMRT1 |
| Genetic variants : HAPMAP | 1761 |
| Genomic Variants (DGV) | DMRT1 [DGVbeta] |
| DECIPHER | DMRT1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | DMRT1 |
| Mutations |
|---|
| ICGC Data Portal | DMRT1 |
| TCGA Data Portal | DMRT1 |
| Broad Tumor Portal | DMRT1 |
| OASIS Portal | DMRT1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | DMRT1 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | DMRT1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search DMRT1 |
| DgiDB (Drug Gene Interaction Database) | DMRT1 |
| DoCM (Curated mutations) | DMRT1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | DMRT1 (select a term) |
| intoGen | DMRT1 |
| Cancer3D | DMRT1(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602424 |
| Orphanet | 1044 |
| DisGeNET | DMRT1 |
| Medgen | DMRT1 |
| Genetic Testing Registry | DMRT1
|
| NextProt | Q9Y5R6 [Medical] |
| TSGene | 1761 |
| GENETests | DMRT1 |
| Target Validation | DMRT1 |
| Huge Navigator |
DMRT1 [HugePedia] |
| snp3D : Map Gene to Disease | 1761 |
| BioCentury BCIQ | DMRT1 |
| ClinGen | DMRT1 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1761 |
| Chemical/Pharm GKB Gene | PA27381 |
| Clinical trial | DMRT1 |
| Miscellaneous |
|---|
| canSAR (ICR) | DMRT1 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 40 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | DMRT1 |
| EVEX | DMRT1 |
| GoPubMed | DMRT1 |
| iHOP | DMRT1 |
