DMRT1 (doublesex and mab-3 related transcription factor 1)

2010-03-01  

Identity

HGNC
LOCATION
9p24.3
LOCUSID
ALIAS
CT154,DMT1
FUSION GENES

Other Information

Locus ID:

NCBI: 1761
MIM: 602424
HGNC: 2934
Ensembl: ENSG00000137090

Variants:

dbSNP: 1761
ClinVar: 1761
TCGA: ENSG00000137090
COSMIC: DMRT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137090ENST00000382276Q9Y5R6
ENSG00000137090ENST00000569227H3BN61

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205438472010Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.147
205438472010Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.147
200077742009The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
215514552011A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.53
216172562011Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour.33
228998672012Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry.22
260058642015An ancient protein-DNA interaction underlying metazoan sex determination.22
214621052010Intestinal iron absorption: regulation by dietary & systemic factors.19
205966602010Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung.12

Citation

Dessen P

DMRT1 (doublesex and mab-3 related transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/52809/dmrt1