| Nomenclature |
|---|
| HGNC (Hugo) | DMRT1 2934 |
| Cards |
|---|
| Entrez_Gene (NCBI) | DMRT1 1761 doublesex and mab-3 related transcription factor 1 |
| Aliases | CT154; DMT1 |
| GeneCards (Weizmann) | DMRT1 |
| Ensembl hg19 (Hinxton) | ENSG00000137090 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000137090 [Gene_View] ENSG00000137090 [Sequence] chr9:841697-969090 [Contig_View] DMRT1 [Vega] |
| ICGC DataPortal | ENSG00000137090 |
| TCGA cBioPortal | DMRT1 |
| AceView (NCBI) | DMRT1 |
| Genatlas (Paris) | DMRT1 |
| WikiGenes | 1761 |
| SOURCE (Princeton) | DMRT1 |
| Genetics Home Reference (NIH) | DMRT1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | DMRT1 - chr9:841697-969090 + 9p24.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | DMRT1 - 9p24.3 [Description] (hg19-Feb_2009) |
| GoldenPath | DMRT1 - 9p24.3 [CytoView hg19] DMRT1 - 9p24.3 [CytoView hg38] |
| ImmunoBase | ENSG00000137090 |
| genome Data Viewer NCBI | DMRT1 [Mapview hg19] |
| OMIM | 602424 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF130728 AJ276801 AK310336 AK313594 AL162131 |
| RefSeq transcript (Entrez) | NM_001363767 NM_021951 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | DMRT1 |
| Alternative Splicing Gallery | ENSG00000137090 |
| Gene Expression | DMRT1 [ NCBI-GEO ] DMRT1 [ EBI - ARRAY_EXPRESS ]
DMRT1 [ SEEK ] DMRT1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | DMRT1 [ Firebrowse - Broad ] |
| Genevisible | Expression of DMRT1 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1761 |
| GTEX Portal (Tissue expression) | DMRT1 |
| Human Protein Atlas | ENSG00000137090-DMRT1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9Y5R6 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9Y5R6 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9Y5R6 |
| Splice isoforms : SwissVar | Q9Y5R6 |
| PhosPhoSitePlus | Q9Y5R6 |
| Domaine pattern : Prosite (Expaxy) | DM_1 (PS40000) DM_2 (PS50809) |
| Domains : Interpro (EBI) | DM_DNA-bd DM_DNA-bd_sf DMRT/dsx/mab-3 DMRT1-like |
| Domain families : Pfam (Sanger) | DM (PF00751) Dmrt1 (PF12374) |
| Domain families : Pfam (NCBI) | pfam00751 pfam12374 |
| Domain families : Smart (EMBL) | DM (SM00301) |
| Conserved Domain (NCBI) | DMRT1 |
| DMDM Disease mutations | 1761 |
| Blocks (Seattle) | DMRT1 |
| PDB (RSDB) | 4YJ0 |
| PDB Europe | 4YJ0 |
| PDB (PDBSum) | 4YJ0 |
| PDB (IMB) | 4YJ0 |
| Structural Biology KnowledgeBase | 4YJ0 |
| SCOP (Structural Classification of Proteins) | 4YJ0 |
| CATH (Classification of proteins structures) | 4YJ0 |
| Superfamily | Q9Y5R6 |
| Human Protein Atlas [tissue] | ENSG00000137090-DMRT1 [tissue] |
| Peptide Atlas | Q9Y5R6 |
| HPRD | 03885 |
| IPI | IPI00001733 IPI00445344 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9Y5R6 |
| IntAct (EBI) | Q9Y5R6 |
| FunCoup | ENSG00000137090 |
| BioGRID | DMRT1 |
| STRING (EMBL) | DMRT1 |
| ZODIAC | DMRT1 |
| Ontologies - Pathways |
|---|
| QuickGO | Q9Y5R6 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II nuclear chromatin cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific proximal promoter sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific male germ cell proliferation male germ cell proliferation chromatin binding nucleus nucleus nucleus cytoplasm spermatogenesis germ cell migration male sex determination intracellular signal transduction identical protein binding negative regulation of meiotic nuclear division negative regulation of meiotic nuclear division positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II male sex differentiation metal ion binding oocyte development Sertoli cell differentiation Sertoli cell development positive regulation of meiosis I regulation of nodal signaling pathway positive regulation of male gonad development |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II nuclear chromatin cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific proximal promoter sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific male germ cell proliferation male germ cell proliferation chromatin binding nucleus nucleus nucleus cytoplasm spermatogenesis germ cell migration male sex determination intracellular signal transduction identical protein binding negative regulation of meiotic nuclear division negative regulation of meiotic nuclear division positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II male sex differentiation metal ion binding oocyte development Sertoli cell differentiation Sertoli cell development positive regulation of meiosis I regulation of nodal signaling pathway positive regulation of male gonad development |
| NDEx Network | DMRT1 |
| Atlas of Cancer Signalling Network | DMRT1 |
| Wikipedia pathways | DMRT1 |
| Orthology - Evolution |
|---|
| OrthoDB | 1761 |
| GeneTree (enSembl) | ENSG00000137090 |
| Phylogenetic Trees/Animal Genes : TreeFam | DMRT1 |
| HOGENOM | Q9Y5R6 |
| Homologs : HomoloGene | DMRT1 |
| Homology/Alignments : Family Browser (UCSC) | DMRT1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | DMRT1/BCL6 [9p24.3/3q27.3] |
| Fusion : Mitelman | SMARCA2/DMRT1 [9p24.3/9p24.3] |
| Fusion Portal | SMARCA2 9p24.3 DMRT1 9p24.3 HNSC |
| Fusion : Quiver | DMRT1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | DMRT1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | DMRT1 |
| dbVar | DMRT1 |
| ClinVar | DMRT1 |
| 1000_Genomes | DMRT1 |
| Exome Variant Server | DMRT1 |
| GNOMAD Browser | ENSG00000137090 |
| Varsome Browser | DMRT1 |
| Genetic variants : HAPMAP | 1761 |
| Genomic Variants (DGV) | DMRT1 [DGVbeta] |
| DECIPHER | DMRT1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | DMRT1 |
| Mutations |
|---|
| ICGC Data Portal | DMRT1 |
| TCGA Data Portal | DMRT1 |
| Broad Tumor Portal | DMRT1 |
| OASIS Portal | DMRT1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | DMRT1 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | DMRT1 |
| Mutations and Diseases : HGMD | DMRT1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search DMRT1 |
| DgiDB (Drug Gene Interaction Database) | DMRT1 |
| DoCM (Curated mutations) | DMRT1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | DMRT1 (select a term) |
| intoGen | DMRT1 |
| Cancer3D | DMRT1(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602424 |
| Orphanet | 1044 |
| DisGeNET | DMRT1 |
| Medgen | DMRT1 |
| Genetic Testing Registry | DMRT1
|
| NextProt | Q9Y5R6 [Medical] |
| TSGene | 1761 |
| GENETests | DMRT1 |
| Target Validation | DMRT1 |
| Huge Navigator |
DMRT1 [HugePedia] |
| snp3D : Map Gene to Disease | 1761 |
| BioCentury BCIQ | DMRT1 |
| ClinGen | DMRT1 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Protein Interactions : CTD | 1761 |
| Pharm GKB Gene | PA27381 |
| Clinical trial | DMRT1 |
| Miscellaneous |
|---|
| canSAR (ICR) | DMRT1 (select the gene name) |
| Harmonizome | DMRT1 |
| DataMed Index | DMRT1 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 42 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | DMRT1 |
| EVEX | DMRT1 |
| GoPubMed | DMRT1 |
