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DNA2 (DNA replication helicase/nuclease 2)

Identity

Alias_namesDNA2L
DNA2 DNA replication helicase 2-like (yeast)
DNA replication helicase 2 homolog (yeast)
Alias_symbol (synonym)KIAA0083
Other aliashDNA2
HGNC (Hugo) DNA2
LocusID (NCBI) 1763
Atlas_Id 50641
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 68414064 and ends at 68471973 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DNA2 (10q21.3) / DNA2 (10q21.3)SLC25A16 (10q21.3) / DNA2 (10q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNA2   2939
Cards
Entrez_Gene (NCBI)DNA2  1763  DNA replication helicase/nuclease 2
AliasesDNA2L; hDNA2
GeneCards (Weizmann)DNA2
Ensembl hg19 (Hinxton)ENSG00000138346 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138346 [Gene_View]  chr10:68414064-68471973 [Contig_View]  DNA2 [Vega]
ICGC DataPortalENSG00000138346
TCGA cBioPortalDNA2
AceView (NCBI)DNA2
Genatlas (Paris)DNA2
WikiGenes1763
SOURCE (Princeton)DNA2
Genetics Home Reference (NIH)DNA2
Genomic and cartography
GoldenPath hg38 (UCSC)DNA2  -     chr10:68414064-68471973 -  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNA2  -     10q21.3   [Description]    (hg19-Feb_2009)
EnsemblDNA2 - 10q21.3 [CytoView hg19]  DNA2 - 10q21.3 [CytoView hg38]
Mapping of homologs : NCBIDNA2 [Mapview hg19]  DNA2 [Mapview hg38]
OMIM601810   615156   615807   
Gene and transcription
Genbank (Entrez)AK307939 AK308333 AK308358 BC017003 BC028188
RefSeq transcript (Entrez)NM_001080449
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNA2
Cluster EST : UnigeneHs.532446 [ NCBI ]
CGAP (NCI)Hs.532446
Alternative Splicing GalleryENSG00000138346
Gene ExpressionDNA2 [ NCBI-GEO ]   DNA2 [ EBI - ARRAY_EXPRESS ]   DNA2 [ SEEK ]   DNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)DNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1763
GTEX Portal (Tissue expression)DNA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51530   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51530  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51530
Splice isoforms : SwissVarP51530
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   
PhosPhoSitePlusP51530
Domains : Interpro (EBI)DNA_replication_fac_Dna2_N    P-loop_NTPase   
Domain families : Pfam (Sanger)Dna2 (PF08696)   
Domain families : Pfam (NCBI)pfam08696   
Conserved Domain (NCBI)DNA2
DMDM Disease mutations1763
Blocks (Seattle)DNA2
PDB (SRS)5EAY   
PDB (PDBSum)5EAY   
PDB (IMB)5EAY   
PDB (RSDB)5EAY   
Structural Biology KnowledgeBase5EAY   
SCOP (Structural Classification of Proteins)5EAY   
CATH (Classification of proteins structures)5EAY   
SuperfamilyP51530
Human Protein AtlasENSG00000138346
Peptide AtlasP51530
IPIIPI00816801   IPI00816670   IPI01022035   IPI01022599   IPI00216142   IPI01022609   
Protein Interaction databases
DIP (DOE-UCLA)P51530
IntAct (EBI)P51530
FunCoupENSG00000138346
BioGRIDDNA2
STRING (EMBL)DNA2
ZODIACDNA2
Ontologies - Pathways
QuickGOP51530
Ontology : AmiGODNA replication checkpoint  telomere maintenance via recombination  telomere maintenance  DNA double-strand break processing  DNA synthesis involved in DNA repair  strand displacement  nuclear chromosome, telomeric region  DNA binding  DNA helicase activity  DNA helicase activity  helicase activity  nuclease activity  protein binding  ATP binding  nucleus  nucleoplasm  mitochondrion  gamma DNA polymerase complex  DNA replication  DNA replication  mitochondrial DNA replication  base-excision repair  ATPase activity  site-specific endodeoxyribonuclease activity, specific for altered base  5'-flap endonuclease activity  DNA duplex unwinding  DNA replication, Okazaki fragment processing  mitochondrial nucleoid  DNA replication, removal of RNA primer  5'-3' DNA helicase activity  single-stranded DNA-dependent ATPase activity  mitochondrial DNA repair  G-quadruplex DNA unwinding  positive regulation of DNA replication  metal ion binding  4 iron, 4 sulfur cluster binding  nucleic acid phosphodiester bond hydrolysis  t-circle formation  regulation of signal transduction by p53 class mediator  mitotic telomere maintenance via semi-conservative replication  
Ontology : EGO-EBIDNA replication checkpoint  telomere maintenance via recombination  telomere maintenance  DNA double-strand break processing  DNA synthesis involved in DNA repair  strand displacement  nuclear chromosome, telomeric region  DNA binding  DNA helicase activity  DNA helicase activity  helicase activity  nuclease activity  protein binding  ATP binding  nucleus  nucleoplasm  mitochondrion  gamma DNA polymerase complex  DNA replication  DNA replication  mitochondrial DNA replication  base-excision repair  ATPase activity  site-specific endodeoxyribonuclease activity, specific for altered base  5'-flap endonuclease activity  DNA duplex unwinding  DNA replication, Okazaki fragment processing  mitochondrial nucleoid  DNA replication, removal of RNA primer  5'-3' DNA helicase activity  single-stranded DNA-dependent ATPase activity  mitochondrial DNA repair  G-quadruplex DNA unwinding  positive regulation of DNA replication  metal ion binding  4 iron, 4 sulfur cluster binding  nucleic acid phosphodiester bond hydrolysis  t-circle formation  regulation of signal transduction by p53 class mediator  mitotic telomere maintenance via semi-conservative replication  
Pathways : KEGGDNA replication   
NDEx NetworkDNA2
Atlas of Cancer Signalling NetworkDNA2
Wikipedia pathwaysDNA2
Orthology - Evolution
OrthoDB1763
GeneTree (enSembl)ENSG00000138346
Phylogenetic Trees/Animal Genes : TreeFamDNA2
HOVERGENP51530
HOGENOMP51530
Homologs : HomoloGeneDNA2
Homology/Alignments : Family Browser (UCSC)DNA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNA2
dbVarDNA2
ClinVarDNA2
1000_GenomesDNA2 
Exome Variant ServerDNA2
ExAC (Exome Aggregation Consortium)DNA2 (select the gene name)
Genetic variants : HAPMAP1763
Genomic Variants (DGV)DNA2 [DGVbeta]
DECIPHERDNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNA2 
Mutations
ICGC Data PortalDNA2 
TCGA Data PortalDNA2 
Broad Tumor PortalDNA2
OASIS PortalDNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DNA2
DgiDB (Drug Gene Interaction Database)DNA2
DoCM (Curated mutations)DNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNA2 (select a term)
intoGenDNA2
Cancer3DDNA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601810    615156    615807   
Orphanet22065   
MedgenDNA2
Genetic Testing Registry DNA2
NextProtP51530 [Medical]
TSGene1763
GENETestsDNA2
Target ValidationDNA2
Huge Navigator DNA2 [HugePedia]
snp3D : Map Gene to Disease1763
BioCentury BCIQDNA2
ClinGenDNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1763
Chemical/Pharm GKB GenePA162383798
Clinical trialDNA2
Miscellaneous
canSAR (ICR)DNA2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNA2
EVEXDNA2
GoPubMedDNA2
iHOPDNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:59:40 CEST 2017

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