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DNA2 (DNA replication helicase/nuclease 2)

Identity

Alias (NCBI)DNA2L
hDNA2
HGNC (Hugo) DNA2
HGNC Alias symbKIAA0083
HGNC Previous nameDNA2L
HGNC Previous nameDNA2 DNA replication helicase 2-like (yeast)
 DNA replication helicase 2 homolog (yeast)
LocusID (NCBI) 1763
Atlas_Id 50641
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 68414064 and ends at 68471973 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNA2 (10q21.3) / DNA2 (10q21.3)SLC25A16 (10q21.3) / DNA2 (10q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DNA2   2939
Cards
Entrez_Gene (NCBI)DNA2    DNA replication helicase/nuclease 2
AliasesDNA2L; hDNA2
GeneCards (Weizmann)DNA2
Ensembl hg19 (Hinxton)ENSG00000138346 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138346 [Gene_View]  ENSG00000138346 [Sequence]  chr10:68414064-68471973 [Contig_View]  DNA2 [Vega]
ICGC DataPortalENSG00000138346
TCGA cBioPortalDNA2
AceView (NCBI)DNA2
Genatlas (Paris)DNA2
SOURCE (Princeton)DNA2
Genetics Home Reference (NIH)DNA2
Genomic and cartography
GoldenPath hg38 (UCSC)DNA2  -     chr10:68414064-68471973 -  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNA2  -     10q21.3   [Description]    (hg19-Feb_2009)
GoldenPathDNA2 - 10q21.3 [CytoView hg19]  DNA2 - 10q21.3 [CytoView hg38]
ImmunoBaseENSG00000138346
Genome Data Viewer NCBIDNA2 [Mapview hg19]  
OMIM601810   615156   615807   
Gene and transcription
Genbank (Entrez)AK307939 AK308333 AK308358 BC017003 BC028188
RefSeq transcript (Entrez)NM_001080449
Consensus coding sequences : CCDS (NCBI)DNA2
Gene ExpressionDNA2 [ NCBI-GEO ]   DNA2 [ EBI - ARRAY_EXPRESS ]   DNA2 [ SEEK ]   DNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)DNA2 [ Firebrowse - Broad ]
GenevisibleExpression of DNA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1763
GTEX Portal (Tissue expression)DNA2
Human Protein AtlasENSG00000138346-DNA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51530   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51530  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51530
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP51530
Domains : Interpro (EBI)Dna2    DNA2/NAM7-like_C    DNA2/NAM7_AAA_11    DNA_replication_fac_Dna2_N    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA_11 (PF13086)    AAA_12 (PF13087)    Dna2 (PF08696)   
Domain families : Pfam (NCBI)pfam13086    pfam13087    pfam08696   
Conserved Domain (NCBI)DNA2
PDB (RSDB)5EAY   
PDB Europe5EAY   
PDB (PDBSum)5EAY   
PDB (IMB)5EAY   
Structural Biology KnowledgeBase5EAY   
SCOP (Structural Classification of Proteins)5EAY   
CATH (Classification of proteins structures)5EAY   
SuperfamilyP51530
AlphaFold pdb e-kbP51530   
Human Protein Atlas [tissue]ENSG00000138346-DNA2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P51530
IntAct (EBI)P51530
BioGRIDDNA2
STRING (EMBL)DNA2
ZODIACDNA2
Ontologies - Pathways
QuickGOP51530
Ontology : AmiGODNA replication checkpoint signaling  telomere maintenance  DNA double-strand break processing  chromosome, telomeric region  DNA binding  DNA helicase activity  DNA helicase activity  RNA binding  helicase activity  nuclease activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  DNA replication  DNA replication  mitochondrial DNA replication  base-excision repair  site-specific endodeoxyribonuclease activity, specific for altered base  5'-flap endonuclease activity  5'-flap endonuclease activity  single-stranded DNA helicase activity  telomere maintenance via semi-conservative replication  DNA duplex unwinding  DNA replication, Okazaki fragment processing  mitochondrial nucleoid  DNA replication, removal of RNA primer  5'-3' DNA helicase activity  mitochondrial DNA repair  G-quadruplex DNA unwinding  positive regulation of DNA replication  metal ion binding  4 iron, 4 sulfur cluster binding  replication fork reversal  nucleic acid phosphodiester bond hydrolysis  t-circle formation  ATP hydrolysis activity  regulation of signal transduction by p53 class mediator  mitotic telomere maintenance via semi-conservative replication  
Ontology : EGO-EBIDNA replication checkpoint signaling  telomere maintenance  DNA double-strand break processing  chromosome, telomeric region  DNA binding  DNA helicase activity  DNA helicase activity  RNA binding  helicase activity  nuclease activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  DNA replication  DNA replication  mitochondrial DNA replication  base-excision repair  site-specific endodeoxyribonuclease activity, specific for altered base  5'-flap endonuclease activity  5'-flap endonuclease activity  single-stranded DNA helicase activity  telomere maintenance via semi-conservative replication  DNA duplex unwinding  DNA replication, Okazaki fragment processing  mitochondrial nucleoid  DNA replication, removal of RNA primer  5'-3' DNA helicase activity  mitochondrial DNA repair  G-quadruplex DNA unwinding  positive regulation of DNA replication  metal ion binding  4 iron, 4 sulfur cluster binding  replication fork reversal  nucleic acid phosphodiester bond hydrolysis  t-circle formation  ATP hydrolysis activity  regulation of signal transduction by p53 class mediator  mitotic telomere maintenance via semi-conservative replication  
Pathways : KEGGDNA replication   
NDEx NetworkDNA2
Atlas of Cancer Signalling NetworkDNA2
Wikipedia pathwaysDNA2
Orthology - Evolution
OrthoDB1763
GeneTree (enSembl)ENSG00000138346
Phylogenetic Trees/Animal Genes : TreeFamDNA2
Homologs : HomoloGeneDNA2
Homology/Alignments : Family Browser (UCSC)DNA2
Gene fusions - Rearrangements
Fusion : QuiverDNA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNA2
dbVarDNA2
ClinVarDNA2
MonarchDNA2
1000_GenomesDNA2 
Exome Variant ServerDNA2
GNOMAD BrowserENSG00000138346
Varsome BrowserDNA2
ACMGDNA2 variants
VarityP51530
Genomic Variants (DGV)DNA2 [DGVbeta]
DECIPHERDNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNA2 
Mutations
ICGC Data PortalDNA2 
TCGA Data PortalDNA2 
Broad Tumor PortalDNA2
OASIS PortalDNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDNA2
Mutations and Diseases : HGMDDNA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDNA2
DgiDB (Drug Gene Interaction Database)DNA2
DoCM (Curated mutations)DNA2
CIViC (Clinical Interpretations of Variants in Cancer)DNA2
Cancer3DDNA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601810    615156    615807   
Orphanet22065   
DisGeNETDNA2
MedgenDNA2
Genetic Testing Registry DNA2
NextProtP51530 [Medical]
GENETestsDNA2
Target ValidationDNA2
Huge Navigator DNA2 [HugePedia]
ClinGenDNA2
Clinical trials, drugs, therapy
MyCancerGenomeDNA2
Protein Interactions : CTDDNA2
Pharm GKB GenePA162383798
PharosP51530
Clinical trialDNA2
Miscellaneous
canSAR (ICR)DNA2
HarmonizomeDNA2
DataMed IndexDNA2
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:56 CEST 2021

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