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DNAH3 (dynein axonemal heavy chain 3)

Identity

Alias_namesdynein, axonemal, heavy polypeptide 3
Alias_symbol (synonym)Dnahc3b
DLP3
Hsadhc3
DKFZp434N074
Other aliasDNAHC3-B
DNAHC3B
HDHC8
HEL-36
HSADHC3
HGNC (Hugo) DNAH3
LocusID (NCBI) 55567
Atlas_Id 62551
Location 16p12.3  [Link to chromosome band 16p12]
Location_base_pair Starts at 20933111 and ends at 21150807 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACSM1 (16p12.3) / DNAH3 (16p12.3)DNAH3 (16p12.3) / DNAH3 (16p12.3)GNL2 (1p34.3) / DNAH3 (16p12.3)
TMEM159 (16p12.3) / DNAH3 (16p12.3)GNL2 DNAH3TMEM159 DNAH3
ACSM1 DNAH3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNAH3   2949
Cards
Entrez_Gene (NCBI)DNAH3  55567  dynein axonemal heavy chain 3
AliasesDNAHC3-B; DNAHC3B; HDHC8; HEL-36; 
HSADHC3
GeneCards (Weizmann)DNAH3
Ensembl hg19 (Hinxton)ENSG00000158486 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158486 [Gene_View]  chr16:20933111-21150807 [Contig_View]  DNAH3 [Vega]
ICGC DataPortalENSG00000158486
TCGA cBioPortalDNAH3
AceView (NCBI)DNAH3
Genatlas (Paris)DNAH3
WikiGenes55567
SOURCE (Princeton)DNAH3
Genetics Home Reference (NIH)DNAH3
Genomic and cartography
GoldenPath hg38 (UCSC)DNAH3  -     chr16:20933111-21150807 -  16p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNAH3  -     16p12.3   [Description]    (hg19-Feb_2009)
EnsemblDNAH3 - 16p12.3 [CytoView hg19]  DNAH3 - 16p12.3 [CytoView hg38]
Mapping of homologs : NCBIDNAH3 [Mapview hg19]  DNAH3 [Mapview hg38]
OMIM603334   
Gene and transcription
Genbank (Entrez)AF494040 AJ132085 AK026793 AK056509 AK125907
RefSeq transcript (Entrez)NM_001347886 NM_017539
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNAH3
Cluster EST : UnigeneHs.526500 [ NCBI ]
CGAP (NCI)Hs.526500
Alternative Splicing GalleryENSG00000158486
Gene ExpressionDNAH3 [ NCBI-GEO ]   DNAH3 [ EBI - ARRAY_EXPRESS ]   DNAH3 [ SEEK ]   DNAH3 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAH3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55567
GTEX Portal (Tissue expression)DNAH3
Human Protein AtlasENSG00000158486-DNAH3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TD57   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TD57  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TD57
Splice isoforms : SwissVarQ8TD57
PhosPhoSitePlusQ8TD57
Domains : Interpro (EBI)AAA+_ATPase    DHC_fam    Dynein_HC_stalk    Dynein_heavy_chain_D4_dom    Dynein_heavy_dom    Dynein_heavy_dom-2    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA_8 (PF12780)    DHC_N2 (PF08393)    Dynein_heavy (PF03028)    MT (PF12777)   
Domain families : Pfam (NCBI)pfam12780    pfam08393    pfam03028    pfam12777   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)DNAH3
DMDM Disease mutations55567
Blocks (Seattle)DNAH3
SuperfamilyQ8TD57
Human Protein Atlas [tissue]ENSG00000158486-DNAH3 [tissue]
Peptide AtlasQ8TD57
HPRD04513
IPIIPI00152462   IPI00743808   IPI00885160   IPI00909996   IPI00018083   
Protein Interaction databases
DIP (DOE-UCLA)Q8TD57
IntAct (EBI)Q8TD57
FunCoupENSG00000158486
BioGRIDDNAH3
STRING (EMBL)DNAH3
ZODIACDNAH3
Ontologies - Pathways
QuickGOQ8TD57
Ontology : AmiGOmicrotubule motor activity  ATP binding  cytoplasm  axonemal dynein complex  microtubule  microtubule-based movement  cilium-dependent cell motility  
Ontology : EGO-EBImicrotubule motor activity  ATP binding  cytoplasm  axonemal dynein complex  microtubule  microtubule-based movement  cilium-dependent cell motility  
Pathways : BIOCARTALissencephaly gene (LIS1) in neuronal migration and development [Genes]   
Pathways : KEGGHuntington's disease   
NDEx NetworkDNAH3
Atlas of Cancer Signalling NetworkDNAH3
Wikipedia pathwaysDNAH3
Orthology - Evolution
OrthoDB55567
GeneTree (enSembl)ENSG00000158486
Phylogenetic Trees/Animal Genes : TreeFamDNAH3
HOVERGENQ8TD57
HOGENOMQ8TD57
Homologs : HomoloGeneDNAH3
Homology/Alignments : Family Browser (UCSC)DNAH3
Gene fusions - Rearrangements
Fusion: TCGA_MDACCGNL2 DNAH3
Fusion: TCGA_MDACCTMEM159 DNAH3
Fusion: TCGA_MDACCACSM1 DNAH3
Tumor Fusion PortalDNAH3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAH3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAH3
dbVarDNAH3
ClinVarDNAH3
1000_GenomesDNAH3 
Exome Variant ServerDNAH3
ExAC (Exome Aggregation Consortium)ENSG00000158486
GNOMAD BrowserENSG00000158486
Genetic variants : HAPMAP55567
Genomic Variants (DGV)DNAH3 [DGVbeta]
DECIPHERDNAH3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNAH3 
Mutations
ICGC Data PortalDNAH3 
TCGA Data PortalDNAH3 
Broad Tumor PortalDNAH3
OASIS PortalDNAH3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAH3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNAH3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAH3
DgiDB (Drug Gene Interaction Database)DNAH3
DoCM (Curated mutations)DNAH3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAH3 (select a term)
intoGenDNAH3
Cancer3DDNAH3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603334   
Orphanet
DisGeNETDNAH3
MedgenDNAH3
Genetic Testing Registry DNAH3
NextProtQ8TD57 [Medical]
TSGene55567
GENETestsDNAH3
Target ValidationDNAH3
Huge Navigator DNAH3 [HugePedia]
snp3D : Map Gene to Disease55567
BioCentury BCIQDNAH3
ClinGenDNAH3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55567
Chemical/Pharm GKB GenePA27402
Clinical trialDNAH3
Miscellaneous
canSAR (ICR)DNAH3 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAH3
EVEXDNAH3
GoPubMedDNAH3
iHOPDNAH3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:33:08 CET 2017

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