Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DNAH8 (dynein axonemal heavy chain 8)

Identity

Other aliasATPase
hdhc9
HGNC (Hugo) DNAH8
LocusID (NCBI) 1769
Atlas_Id 57403
Location 6p21.2  [Link to chromosome band 6p21]
Location_base_pair Starts at 38715341 and ends at 39030798 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAH8 (6p21.2) / TMEM217 (6p21.2)DTNBP1 (6p22.3) / DNAH8 (6p21.2)FOXP4 (6p21.1) / DNAH8 (6p21.2)
GMDS (6p25.3) / DNAH8 (6p21.2)ZFAND3 (6p21.2) / DNAH8 (6p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  DNAH8/TMEM217 (6p21)
FOXP4/DNAH8 (6p21)
ZFAND3/DNAH8 (6p21)
t(6;6)(p21;p22) DTNBP1/DNAH8
t(6;6)(p21;p25) GMDS/DNAH8


External links

Nomenclature
HGNC (Hugo)DNAH8   2952
Cards
Entrez_Gene (NCBI)DNAH8  1769  dynein axonemal heavy chain 8
AliasesATPase; hdhc9
GeneCards (Weizmann)DNAH8
Ensembl hg19 (Hinxton)ENSG00000124721 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124721 [Gene_View]  ENSG00000124721 [Sequence]  chr6:38715341-39030798 [Contig_View]  DNAH8 [Vega]
ICGC DataPortalENSG00000124721
TCGA cBioPortalDNAH8
AceView (NCBI)DNAH8
Genatlas (Paris)DNAH8
WikiGenes1769
SOURCE (Princeton)DNAH8
Genetics Home Reference (NIH)DNAH8
Genomic and cartography
GoldenPath hg38 (UCSC)DNAH8  -     chr6:38715341-39030798 +  6p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNAH8  -     6p21.2   [Description]    (hg19-Feb_2009)
EnsemblDNAH8 - 6p21.2 [CytoView hg19]  DNAH8 - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBIDNAH8 [Mapview hg19]  DNAH8 [Mapview hg38]
OMIM603337   
Gene and transcription
Genbank (Entrez)AF356519 AF527621 AF527622 AF527623 AJ132091
RefSeq transcript (Entrez)NM_001206927 NM_001371
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNAH8
Cluster EST : UnigeneHs.686107 [ NCBI ]
CGAP (NCI)Hs.686107
Alternative Splicing GalleryENSG00000124721
Gene ExpressionDNAH8 [ NCBI-GEO ]   DNAH8 [ EBI - ARRAY_EXPRESS ]   DNAH8 [ SEEK ]   DNAH8 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAH8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1769
GTEX Portal (Tissue expression)DNAH8
Human Protein AtlasENSG00000124721-DNAH8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96JB1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96JB1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96JB1
Splice isoforms : SwissVarQ96JB1
PhosPhoSitePlusQ96JB1
Domains : Interpro (EBI)AAA+_ATPase    AAA_6    ATPase_dyneun-rel_AAA    DHC_D5    DHC_fam    Dynein_HC_stalk    Dynein_heavy_chain_D4_dom    Dynein_heavy_dom    Dynein_heavy_dom-1    Dynein_heavy_dom-2    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA_5 (PF07728)    AAA_6 (PF12774)    AAA_8 (PF12780)    AAA_9 (PF12781)    DHC_N1 (PF08385)    DHC_N2 (PF08393)    Dynein_heavy (PF03028)    MT (PF12777)   
Domain families : Pfam (NCBI)pfam07728    pfam12774    pfam12780    pfam12781    pfam08385    pfam08393    pfam03028    pfam12777   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)DNAH8
DMDM Disease mutations1769
Blocks (Seattle)DNAH8
SuperfamilyQ96JB1
Human Protein Atlas [tissue]ENSG00000124721-DNAH8 [tissue]
Peptide AtlasQ96JB1
IPIIPI00014845   IPI00478021   IPI00903184   IPI00873991   IPI00552749   
Protein Interaction databases
DIP (DOE-UCLA)Q96JB1
IntAct (EBI)Q96JB1
FunCoupENSG00000124721
BioGRIDDNAH8
STRING (EMBL)DNAH8
ZODIACDNAH8
Ontologies - Pathways
QuickGOQ96JB1
Ontology : AmiGOmicrotubule motor activity  ATP binding  axonemal dynein complex  microtubule  microtubule-based movement  ATP-dependent microtubule motor activity, minus-end-directed  dynein complex  dynein complex  outer dynein arm  outer dynein arm assembly  dynein light chain binding  dynein intermediate chain binding  dynein light intermediate chain binding  cilium-dependent cell motility  
Ontology : EGO-EBImicrotubule motor activity  ATP binding  axonemal dynein complex  microtubule  microtubule-based movement  ATP-dependent microtubule motor activity, minus-end-directed  dynein complex  dynein complex  outer dynein arm  outer dynein arm assembly  dynein light chain binding  dynein intermediate chain binding  dynein light intermediate chain binding  cilium-dependent cell motility  
NDEx NetworkDNAH8
Atlas of Cancer Signalling NetworkDNAH8
Wikipedia pathwaysDNAH8
Orthology - Evolution
OrthoDB1769
GeneTree (enSembl)ENSG00000124721
Phylogenetic Trees/Animal Genes : TreeFamDNAH8
HOVERGENQ96JB1
HOGENOMQ96JB1
Homologs : HomoloGeneDNAH8
Homology/Alignments : Family Browser (UCSC)DNAH8
Gene fusions - Rearrangements
Fusion : QuiverDNAH8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAH8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAH8
dbVarDNAH8
ClinVarDNAH8
1000_GenomesDNAH8 
Exome Variant ServerDNAH8
ExAC (Exome Aggregation Consortium)ENSG00000124721
GNOMAD BrowserENSG00000124721
Varsome BrowserDNAH8
Genetic variants : HAPMAP1769
Genomic Variants (DGV)DNAH8 [DGVbeta]
DECIPHERDNAH8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNAH8 
Mutations
ICGC Data PortalDNAH8 
TCGA Data PortalDNAH8 
Broad Tumor PortalDNAH8
OASIS PortalDNAH8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAH8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNAH8
BioMutasearch DNAH8
DgiDB (Drug Gene Interaction Database)DNAH8
DoCM (Curated mutations)DNAH8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAH8 (select a term)
intoGenDNAH8
Cancer3DDNAH8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603337   
Orphanet
DisGeNETDNAH8
MedgenDNAH8
Genetic Testing Registry DNAH8
NextProtQ96JB1 [Medical]
TSGene1769
GENETestsDNAH8
Target ValidationDNAH8
Huge Navigator DNAH8 [HugePedia]
snp3D : Map Gene to Disease1769
BioCentury BCIQDNAH8
ClinGenDNAH8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1769
Chemical/Pharm GKB GenePA27405
Clinical trialDNAH8
Miscellaneous
canSAR (ICR)DNAH8 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAH8
EVEXDNAH8
GoPubMedDNAH8
iHOPDNAH8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:02:46 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.