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DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1)

Identity

Other namesHSPF1
Hdj1
Hsp40
RSPH16B
Sis1
HGNC (Hugo) DNAJB1
LocusID (NCBI) 3337
Atlas_Id 46862
Location 19p13.12
Location_base_pair Starts at 14625576 and ends at 14628674 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DNAJB1 (19p13.12) / ATP13A1 (19p13.11)DNAJB1 (19p13.12) / CFAP46 (10q26.3)DNAJB1 (19p13.12) / PRKACA (19p13.12)
SCLT1 (4q28.2) / DNAJB1 (19p13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNAJB1   5270
Cards
Entrez_Gene (NCBI)DNAJB1  3337  DnaJ heat shock protein family (Hsp40) member B1
AliasesHSPF1; Hdj1; Hsp40; RSPH16B; 
Sis1
GeneCards (Weizmann)DNAJB1
Ensembl hg19 (Hinxton)ENSG00000132002 [Gene_View]  chr19:14625576-14628674 [Contig_View]  DNAJB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000132002 [Gene_View]  chr19:14625576-14628674 [Contig_View]  DNAJB1 [Vega]
ICGC DataPortalENSG00000132002
TCGA cBioPortalDNAJB1
AceView (NCBI)DNAJB1
Genatlas (Paris)DNAJB1
WikiGenes3337
SOURCE (Princeton)DNAJB1
Genomic and cartography
GoldenPath hg19 (UCSC)DNAJB1  -     chr19:14625576-14628674 -  19p13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DNAJB1  -     19p13.12   [Description]    (hg38-Dec_2013)
EnsemblDNAJB1 - 19p13.12 [CytoView hg19]  DNAJB1 - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIDNAJB1 [Mapview hg19]  DNAJB1 [Mapview hg38]
OMIM604572   
Gene and transcription
Genbank (Entrez)AK092989 AK296609 AK301817 AK312624 BC002352
RefSeq transcript (Entrez)NM_001300914 NM_001313964 NM_006145
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)DNAJB1
Cluster EST : UnigeneHs.515210 [ NCBI ]
CGAP (NCI)Hs.515210
Alternative Splicing GalleryENSG00000132002
Gene ExpressionDNAJB1 [ NCBI-GEO ]   DNAJB1 [ EBI - ARRAY_EXPRESS ]   DNAJB1 [ SEEK ]   DNAJB1 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAJB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3337
GTEX Portal (Tissue expression)DNAJB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25685 (Uniprot)
NextProtP25685  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25685
Splice isoforms : SwissVarP25685 (Swissvar)
PhosPhoSitePlusP25685
Domaine pattern : Prosite (Expaxy)DNAJ_1 (PS00636)    DNAJ_2 (PS50076)   
Domains : Interpro (EBI)DnaJ_C    DnaJ_domain    DnaJ_domain_CS    HSP40/DnaJ_pept-bd   
Domain families : Pfam (Sanger)DnaJ (PF00226)    DnaJ_C (PF01556)   
Domain families : Pfam (NCBI)pfam00226    pfam01556   
Domain families : Smart (EMBL)DnaJ (SM00271)  
DMDM Disease mutations3337
Blocks (Seattle)DNAJB1
PDB (SRS)1HDJ    2QLD    3AGX    3AGY    3AGZ    4WB7   
PDB (PDBSum)1HDJ    2QLD    3AGX    3AGY    3AGZ    4WB7   
PDB (IMB)1HDJ    2QLD    3AGX    3AGY    3AGZ    4WB7   
PDB (RSDB)1HDJ    2QLD    3AGX    3AGY    3AGZ    4WB7   
Structural Biology KnowledgeBase1HDJ    2QLD    3AGX    3AGY    3AGZ    4WB7   
SCOP (Structural Classification of Proteins)1HDJ    2QLD    3AGX    3AGY    3AGZ    4WB7   
CATH (Classification of proteins structures)1HDJ    2QLD    3AGX    3AGY    3AGZ    4WB7   
SuperfamilyP25685
Human Protein AtlasENSG00000132002
Peptide AtlasP25685
HPRD05198
IPIIPI00015947   IPI01010489   IPI00984730   
Protein Interaction databases
DIP (DOE-UCLA)P25685
IntAct (EBI)P25685
FunCoupENSG00000132002
BioGRIDDNAJB1
STRING (EMBL)DNAJB1
ZODIACDNAJB1
Ontologies - Pathways
QuickGOP25685
Ontology : AmiGOATPase activator activity  ATPase activator activity  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cytosol  response to unfolded protein  Hsp70 protein binding  positive regulation of ATPase activity  unfolded protein binding  chaperone mediated protein folding requiring cofactor  chaperone binding  ATPase binding  extracellular exosome  chaperone cofactor-dependent protein refolding  negative regulation of inclusion body assembly  regulation of cellular response to heat  
Ontology : EGO-EBIATPase activator activity  ATPase activator activity  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cytosol  response to unfolded protein  Hsp70 protein binding  positive regulation of ATPase activity  unfolded protein binding  chaperone mediated protein folding requiring cofactor  chaperone binding  ATPase binding  extracellular exosome  chaperone cofactor-dependent protein refolding  negative regulation of inclusion body assembly  regulation of cellular response to heat  
Pathways : BIOCARTAPrion Pathway [Genes]    Hypoxia and p53 in the Cardiovascular system [Genes]   
Pathways : KEGGProtein processing in endoplasmic reticulum    Influenza A   
NDEx Network
Atlas of Cancer Signalling NetworkDNAJB1
Wikipedia pathwaysDNAJB1
Orthology - Evolution
OrthoDB3337
GeneTree (enSembl)ENSG00000132002
Phylogenetic Trees/Animal Genes : TreeFamDNAJB1
Homologs : HomoloGeneDNAJB1
Homology/Alignments : Family Browser (UCSC)DNAJB1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerDNAJB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAJB1
dbVarDNAJB1
ClinVarDNAJB1
1000_GenomesDNAJB1 
Exome Variant ServerDNAJB1
ExAC (Exome Aggregation Consortium)DNAJB1 (select the gene name)
Genetic variants : HAPMAP3337
Genomic Variants (DGV)DNAJB1 [DGVbeta]
Mutations
ICGC Data PortalDNAJB1 
TCGA Data PortalDNAJB1 
Broad Tumor PortalDNAJB1
OASIS PortalDNAJB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAJB1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAJB1
DgiDB (Drug Gene Interaction Database)DNAJB1
DoCM (Curated mutations)DNAJB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAJB1 (select a term)
intoGenDNAJB1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:14625576-14628674  ENSG00000132002
CONAN: Copy Number AnalysisDNAJB1 
Mutations and Diseases : HGMDDNAJB1
OMIM604572   
MedgenDNAJB1
Genetic Testing Registry DNAJB1
NextProtP25685 [Medical]
TSGene3337
GENETestsDNAJB1
Huge Navigator DNAJB1 [HugePedia]
snp3D : Map Gene to Disease3337
BioCentury BCIQDNAJB1
ClinGenDNAJB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3337
Chemical/Pharm GKB GenePA27412
Clinical trialDNAJB1
Miscellaneous
canSAR (ICR)DNAJB1 (select the gene name)
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAJB1
EVEXDNAJB1
GoPubMedDNAJB1
iHOPDNAJB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:00:32 CEST 2016

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