DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11)

2007-04-01  

Identity

HGNC
LOCATION
3q27.3
LOCUSID
ALIAS
ABBP-2,ABBP2,DJ9,Dj-9,EDJ,ERdj3,ERj3,ERj3p,PKD6,PRO1080,UNQ537
FUSION GENES

Other Information

Locus ID:

NCBI: 51726
MIM: 611341
HGNC: 14889
Ensembl: ENSG00000090520

Variants:

dbSNP: 51726
ClinVar: 51726
TCGA: ENSG00000090520
COSMIC: DNAJB11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090520ENST00000265028Q9UBS4
ENSG00000090520ENST00000439351Q9UBS4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
155256762005ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates.77
216731902011BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection.53
253616062015Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.40
203351662010The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3.29
204189072010Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1.28
297063512018Monoallelic Mutations to DNAJB11 Cause Atypical Autosomal-Dominant Polycystic Kidney Disease.26
251269892014ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease.24
233780212013ERdj3 regulates BiP occupancy in living cells.17
218442352011Structural and functional interactions between the cholera toxin A1 subunit and ERdj3/HEDJ, a chaperone of the endoplasmic reticulum.13

Citation

Dessen P

DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47317/dnajb11