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DNAJB2 (DnaJ heat shock protein family (Hsp40) member B2)

Identity

Alias_namesHSJ1
DnaJ (Hsp40) homolog
Alias_symbol (synonym)HSPF3
CMT2T
Other aliasDSMA5
HSJ-1
HGNC (Hugo) DNAJB2
LocusID (NCBI) 3300
Atlas_Id 46852
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 220144040 and ends at 220151622 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DNAJB2 (2q35) / IFRD1 (7q31.1)DNAJB2 (2q35) / NAP1L1 (12q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNAJB2   5228
Cards
Entrez_Gene (NCBI)DNAJB2  3300  DnaJ heat shock protein family (Hsp40) member B2
AliasesCMT2T; DSMA5; HSJ-1; HSJ1; 
HSPF3
GeneCards (Weizmann)DNAJB2
Ensembl hg19 (Hinxton)ENSG00000135924 [Gene_View]  chr2:220144040-220151622 [Contig_View]  DNAJB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000135924 [Gene_View]  chr2:220144040-220151622 [Contig_View]  DNAJB2 [Vega]
ICGC DataPortalENSG00000135924
TCGA cBioPortalDNAJB2
AceView (NCBI)DNAJB2
Genatlas (Paris)DNAJB2
WikiGenes3300
SOURCE (Princeton)DNAJB2
Genetics Home Reference (NIH)DNAJB2
Genomic and cartography
GoldenPath hg19 (UCSC)DNAJB2  -     chr2:220144040-220151622 +  2q35   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DNAJB2  -     2q35   [Description]    (hg38-Dec_2013)
EnsemblDNAJB2 - 2q35 [CytoView hg19]  DNAJB2 - 2q35 [CytoView hg38]
Mapping of homologs : NCBIDNAJB2 [Mapview hg19]  DNAJB2 [Mapview hg38]
OMIM604139   614881   616233   
Gene and transcription
Genbank (Entrez)AK289626 AK292761 AK293888 AK296297 AK312723
RefSeq transcript (Entrez)NM_001039550 NM_006736
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_029553 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)DNAJB2
Cluster EST : UnigeneHs.77768 [ NCBI ]
CGAP (NCI)Hs.77768
Alternative Splicing GalleryENSG00000135924
Gene ExpressionDNAJB2 [ NCBI-GEO ]   DNAJB2 [ EBI - ARRAY_EXPRESS ]   DNAJB2 [ SEEK ]   DNAJB2 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAJB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3300
GTEX Portal (Tissue expression)DNAJB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25686   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25686  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25686
Splice isoforms : SwissVarP25686
PhosPhoSitePlusP25686
Domaine pattern : Prosite (Expaxy)DNAJ_1 (PS00636)    DNAJ_2 (PS50076)    UIM (PS50330)   
Domains : Interpro (EBI)DnaJ_domain    DnaJ_domain_CS    UIM_dom   
Domain families : Pfam (Sanger)DnaJ (PF00226)    UIM (PF02809)   
Domain families : Pfam (NCBI)pfam00226    pfam02809   
Domain families : Smart (EMBL)DnaJ (SM00271)  UIM (SM00726)  
Conserved Domain (NCBI)DNAJB2
DMDM Disease mutations3300
Blocks (Seattle)DNAJB2
PDB (SRS)2LGW   
PDB (PDBSum)2LGW   
PDB (IMB)2LGW   
PDB (RSDB)2LGW   
Structural Biology KnowledgeBase2LGW   
SCOP (Structural Classification of Proteins)2LGW   
CATH (Classification of proteins structures)2LGW   
SuperfamilyP25686
Human Protein AtlasENSG00000135924
Peptide AtlasP25686
HPRD07249
IPIIPI00874105   IPI00220102   IPI00908667   IPI00917047   IPI00925711   IPI00916752   IPI00916360   
Protein Interaction databases
DIP (DOE-UCLA)P25686
IntAct (EBI)P25686
FunCoupENSG00000135924
BioGRIDDNAJB2
STRING (EMBL)DNAJB2
ZODIACDNAJB2
Ontologies - Pathways
QuickGOP25686
Ontology : AmiGOproteasome complex  protein binding  nucleus  cytosol  protein folding  response to unfolded protein  inclusion body  ER-associated ubiquitin-dependent protein catabolic process  Hsp70 protein binding  positive regulation of protein ubiquitination  polyubiquitin binding  ubiquitin protein ligase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of protein localization  protein refolding  unfolded protein binding  chaperone binding  proteasome binding  negative regulation of inclusion body assembly  negative regulation of inclusion body assembly  negative regulation of protein deubiquitination  
Ontology : EGO-EBIproteasome complex  protein binding  nucleus  cytosol  protein folding  response to unfolded protein  inclusion body  ER-associated ubiquitin-dependent protein catabolic process  Hsp70 protein binding  positive regulation of protein ubiquitination  polyubiquitin binding  ubiquitin protein ligase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of protein localization  protein refolding  unfolded protein binding  chaperone binding  proteasome binding  negative regulation of inclusion body assembly  negative regulation of inclusion body assembly  negative regulation of protein deubiquitination  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkDNAJB2
Atlas of Cancer Signalling NetworkDNAJB2
Wikipedia pathwaysDNAJB2
Orthology - Evolution
OrthoDB3300
GeneTree (enSembl)ENSG00000135924
Phylogenetic Trees/Animal Genes : TreeFamDNAJB2
HOVERGENP25686
HOGENOMP25686
Homologs : HomoloGeneDNAJB2
Homology/Alignments : Family Browser (UCSC)DNAJB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAJB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAJB2
dbVarDNAJB2
ClinVarDNAJB2
1000_GenomesDNAJB2 
Exome Variant ServerDNAJB2
ExAC (Exome Aggregation Consortium)DNAJB2 (select the gene name)
Genetic variants : HAPMAP3300
Genomic Variants (DGV)DNAJB2 [DGVbeta]
DECIPHER (Syndromes)2:220144040-220151622  ENSG00000135924
CONAN: Copy Number AnalysisDNAJB2 
Mutations
ICGC Data PortalDNAJB2 
TCGA Data PortalDNAJB2 
Broad Tumor PortalDNAJB2
OASIS PortalDNAJB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAJB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNAJB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAJB2
DgiDB (Drug Gene Interaction Database)DNAJB2
DoCM (Curated mutations)DNAJB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAJB2 (select a term)
intoGenDNAJB2
Cancer3DDNAJB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604139    614881    616233   
Orphanet21492    23470   
MedgenDNAJB2
Genetic Testing Registry DNAJB2
NextProtP25686 [Medical]
TSGene3300
GENETestsDNAJB2
Huge Navigator DNAJB2 [HugePedia]
snp3D : Map Gene to Disease3300
BioCentury BCIQDNAJB2
ClinGenDNAJB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3300
Chemical/Pharm GKB GenePA27415
Clinical trialDNAJB2
Miscellaneous
canSAR (ICR)DNAJB2 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAJB2
EVEXDNAJB2
GoPubMedDNAJB2
iHOPDNAJB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:59:05 CEST 2017

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