DNAJB9 (DnaJ heat shock protein family (Hsp40) member B9)

2007-04-01  

Identity

HGNC
LOCATION
7q31.1
LOCUSID
ALIAS
ERdj4,MDG-1,MDG1,MST049,MSTP049
FUSION GENES

Other Information

Locus ID:

NCBI: 4189
MIM: 602634
HGNC: 6968
Ensembl: ENSG00000128590

Variants:

dbSNP: 4189
ClinVar: 4189
TCGA: ENSG00000128590
COSMIC: DNAJB9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128590ENST00000249356Q9UBS3
ENSG00000128590ENST00000249356Q6FIF1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184009462008ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C.64
291985252017A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.44
251469232015Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53.19
310104802019Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients.2
318730722019Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR.0

Citation

Dessen P

DNAJB9 (DnaJ heat shock protein family (Hsp40) member B9)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47161/dnajb9