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DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1)

Identity

Alias_namesDnaJ (Hsp40) homolog
Alias_symbol (synonym)DNAJL1
ERdj1
MTJ1
Other aliasHTJ1
HGNC (Hugo) DNAJC1
LocusID (NCBI) 64215
Atlas_Id 47352
Location 10p12.31  [Link to chromosome band 10p12]
Location_base_pair Starts at 21756548 and ends at 22003721 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APBB1IP (10p12.1) / DNAJC1 (10p12.31)DNAJC1 (10p12.31) / DCLRE1C (10p13)DNAJC1 (10p12.31) / DNAJC1 (10p12.31)
DNAJC1 (10p12.31) / GTDC1 (2q22.3)DNAJC1 (10p12.31) / MYB (6q23.3)DNAJC1 (10p12.31) / PLEKHF2 (8q22.1)
DNAJC1 (10p12.31) / SFTPD (10q22.3)NEBL (10p12.31) / DNAJC1 (10p12.31)TAF3 (10p14) / DNAJC1 (10p12.31)
ZNF462 (9q31.2) / DNAJC1 (10p12.31)APBB1IP 10p12.1 / DNAJC1 10p12.31DNAJC1 10p12.31 / DCLRE1C 10p13
DNAJC1 10p12.31 / PLEKHF2 8q22.1NEBL 10p12.31 / DNAJC1 10p12.31TAF3 10p14 / DNAJC1 10p12.31
ZNF462 9q31.2 / DNAJC1 10p12.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DNAJC1   20090
Cards
Entrez_Gene (NCBI)DNAJC1  64215  DnaJ heat shock protein family (Hsp40) member C1
AliasesDNAJL1; ERdj1; HTJ1; MTJ1
GeneCards (Weizmann)DNAJC1
Ensembl hg19 (Hinxton)ENSG00000136770 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136770 [Gene_View]  chr10:21756548-22003721 [Contig_View]  DNAJC1 [Vega]
ICGC DataPortalENSG00000136770
TCGA cBioPortalDNAJC1
AceView (NCBI)DNAJC1
Genatlas (Paris)DNAJC1
WikiGenes64215
SOURCE (Princeton)DNAJC1
Genetics Home Reference (NIH)DNAJC1
Genomic and cartography
GoldenPath hg38 (UCSC)DNAJC1  -     chr10:21756548-22003721 -  10p12.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DNAJC1  -     10p12.31   [Description]    (hg19-Feb_2009)
EnsemblDNAJC1 - 10p12.31 [CytoView hg19]  DNAJC1 - 10p12.31 [CytoView hg38]
Mapping of homologs : NCBIDNAJC1 [Mapview hg19]  DNAJC1 [Mapview hg38]
OMIM611207   
Gene and transcription
Genbank (Entrez)AF427142 AK026062 AK027263 AK308369 AY225122
RefSeq transcript (Entrez)NM_022365
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DNAJC1
Cluster EST : UnigeneHs.499000 [ NCBI ]
CGAP (NCI)Hs.499000
Alternative Splicing GalleryENSG00000136770
Gene ExpressionDNAJC1 [ NCBI-GEO ]   DNAJC1 [ EBI - ARRAY_EXPRESS ]   DNAJC1 [ SEEK ]   DNAJC1 [ MEM ]
Gene Expression Viewer (FireBrowse)DNAJC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64215
GTEX Portal (Tissue expression)DNAJC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96KC8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96KC8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96KC8
Splice isoforms : SwissVarQ96KC8
PhosPhoSitePlusQ96KC8
Domaine pattern : Prosite (Expaxy)DNAJ_1 (PS00636)    DNAJ_2 (PS50076)    SANT (PS51293)   
Domains : Interpro (EBI)DnaJ_domain    DnaJ_domain_CS    Homeobox-like    SANT/Myb    SANT_dom   
Domain families : Pfam (Sanger)DnaJ (PF00226)    Myb_DNA-binding (PF00249)   
Domain families : Pfam (NCBI)pfam00226    pfam00249   
Domain families : Smart (EMBL)DnaJ (SM00271)  SANT (SM00717)  
Conserved Domain (NCBI)DNAJC1
DMDM Disease mutations64215
Blocks (Seattle)DNAJC1
PDB (SRS)2CQQ    2CQR   
PDB (PDBSum)2CQQ    2CQR   
PDB (IMB)2CQQ    2CQR   
PDB (RSDB)2CQQ    2CQR   
Structural Biology KnowledgeBase2CQQ    2CQR   
SCOP (Structural Classification of Proteins)2CQQ    2CQR   
CATH (Classification of proteins structures)2CQQ    2CQR   
SuperfamilyQ96KC8
Human Protein AtlasENSG00000136770
Peptide AtlasQ96KC8
HPRD09922
IPIIPI00074870   IPI00645120   IPI00645450   
Protein Interaction databases
DIP (DOE-UCLA)Q96KC8
IntAct (EBI)Q96KC8
FunCoupENSG00000136770
BioGRIDDNAJC1
STRING (EMBL)DNAJC1
ZODIACDNAJC1
Ontologies - Pathways
QuickGOQ96KC8
Ontology : AmiGOATPase activator activity  DNA binding  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  regulation of translation  protein folding  membrane  integral component of membrane  nuclear membrane  positive regulation of ATPase activity  negative regulation of proteolysis  regulation of protein secretion  chaperone binding  
Ontology : EGO-EBIATPase activator activity  DNA binding  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  regulation of translation  protein folding  membrane  integral component of membrane  nuclear membrane  positive regulation of ATPase activity  negative regulation of proteolysis  regulation of protein secretion  chaperone binding  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkDNAJC1
Atlas of Cancer Signalling NetworkDNAJC1
Wikipedia pathwaysDNAJC1
Orthology - Evolution
OrthoDB64215
GeneTree (enSembl)ENSG00000136770
Phylogenetic Trees/Animal Genes : TreeFamDNAJC1
HOVERGENQ96KC8
HOGENOMQ96KC8
Homologs : HomoloGeneDNAJC1
Homology/Alignments : Family Browser (UCSC)DNAJC1
Gene fusions - Rearrangements
Fusion : MitelmanAPBB1IP/DNAJC1 [10p12.1/10p12.31]  [t(10;10)(p12;p12)]  
Fusion : MitelmanDNAJC1/DCLRE1C [10p12.31/10p13]  [t(10;10)(p12;p13)]  
Fusion : MitelmanDNAJC1/PLEKHF2 [10p12.31/8q22.1]  [t(8;10)(q22;p12)]  
Fusion : MitelmanDNAJC1/SFTPD [10p12.31/10q22.3]  [t(10;10)(p12;q22)]  
Fusion : MitelmanNEBL/DNAJC1 [10p12.31/10p12.31]  [t(10;10)(p12;p12)]  
Fusion : MitelmanTAF3/DNAJC1 [10p14/10p12.31]  [t(10;10)(p12;p14)]  
Fusion : MitelmanZNF462/DNAJC1 [9q31.2/10p12.31]  [t(9;10)(q31;p12)]  
Fusion: TCGAAPBB1IP 10p12.1 DNAJC1 10p12.31 SKCM
Fusion: TCGADNAJC1 10p12.31 DCLRE1C 10p13 BRCA
Fusion: TCGADNAJC1 10p12.31 PLEKHF2 8q22.1 BRCA
Fusion: TCGANEBL 10p12.31 DNAJC1 10p12.31 BRCA
Fusion: TCGATAF3 10p14 DNAJC1 10p12.31 LUAD
Fusion: TCGAZNF462 9q31.2 DNAJC1 10p12.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDNAJC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DNAJC1
dbVarDNAJC1
ClinVarDNAJC1
1000_GenomesDNAJC1 
Exome Variant ServerDNAJC1
ExAC (Exome Aggregation Consortium)DNAJC1 (select the gene name)
Genetic variants : HAPMAP64215
Genomic Variants (DGV)DNAJC1 [DGVbeta]
DECIPHERDNAJC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDNAJC1 
Mutations
ICGC Data PortalDNAJC1 
TCGA Data PortalDNAJC1 
Broad Tumor PortalDNAJC1
OASIS PortalDNAJC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDNAJC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDNAJC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DNAJC1
DgiDB (Drug Gene Interaction Database)DNAJC1
DoCM (Curated mutations)DNAJC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DNAJC1 (select a term)
intoGenDNAJC1
Cancer3DDNAJC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611207   
Orphanet
MedgenDNAJC1
Genetic Testing Registry DNAJC1
NextProtQ96KC8 [Medical]
TSGene64215
GENETestsDNAJC1
Target ValidationDNAJC1
Huge Navigator DNAJC1 [HugePedia]
snp3D : Map Gene to Disease64215
BioCentury BCIQDNAJC1
ClinGenDNAJC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64215
Chemical/Pharm GKB GenePA128394706
Clinical trialDNAJC1
Miscellaneous
canSAR (ICR)DNAJC1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDNAJC1
EVEXDNAJC1
GoPubMedDNAJC1
iHOPDNAJC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:43 CEST 2017

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