DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10)

2007-02-01  

Identity

HGNC
DNAJC10
LOCATION
2q32.1
LOCUSID
54431
ALIAS
ERdj5,JPDI,MTHr,PDIA19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54431
MIM: 607987
HGNC: 24637
Ensembl: ENSG00000077232

Variants:

dbSNP: 54431
ClinVar: 54431
TCGA: ENSG00000077232
COSMIC: DNAJC10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077232ENST00000264065Q8IXB1
ENSG00000077232ENST00000418559E7EP04
ENSG00000077232ENST00000444005H7C1G0
ENSG00000077232ENST00000537515Q8IXB1
ENSG00000077232ENST00000613960A0A087WXH7
ENSG00000077232ENST00000616986Q8IXB1
ENSG00000077232ENST00000640034Q71S60
ENSG00000077232ENST00000650903A0A494C1G5

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
186538952008ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.147
184009462008ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C.64
124114432003ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.49
237696722013ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor.37
124466772003JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs.24
233636022013The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation.23
250558722014The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.12
191222392009ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis.11
284790602017The Highly Dynamic Nature of ERdj5 Is Key to Efficient Elimination of Aberrant Protein Oligomers through ER-Associated Degradation.7
145876672003Cloning and identification of a novel cDNA which encodes a putative protein with a DnaJ domain and a thioredoxin active motif, human macrothioredoxin.3

Citation

Dessen P

DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46418/dnajc10